National Association of Medical Examiners position paper: Recommendations for the investigation and certification of deaths in people with epilepsy.

abstract：OBJECTIVE:Guidelines recommend that encephalopathic critically ill children undergo continuous electroencephalographic (CEEG) monitoring for electrographic seizure (ES) identification and management. However, limited data exist on antiseizure medication (ASM) safety for ES treatment in critically ill children. METHODS...

journal_title：Epilepsia

authors： Fung FW,Jacobwitz M,Vala L,Parikh D,Donnelly M,Xiao R,Topjian AA,Abend NS

更新日期：2019-10-01 00:00:00

abstract：:Eslicarbazepine acetate (ESL) is a novel once-daily antiepileptic drug (AED) approved in Europe since 2009 that was found to be efficacious and well tolerated in a phase III clinical program in adult patients with partial onset seizures previously not controlled with treatment with one to three AEDs, including carbama...

journal_title：Epilepsia

authors： Bialer M,Soares-da-Silva P

更新日期：2012-06-01 00:00:00

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：:Fibroblast growth-factor homologous factor (FHF1) gene variants have recently been associated with developmental and epileptic encephalopathy (DEE). FHF1 encodes a cytosolic protein that modulates neuronal sodium channel gating. We aim to refine the electroclinical phenotypic spectrum of patients with pathogenic FHF1 ...

journal_title：Epilepsia

authors： Trivisano M,Ferretti A,Bebin E,Huh L,Lesca G,Siekierska A,Takeguchi R,Carneiro M,De Palma L,Guella I,Haginoya K,Shi RM,Kikuchi A,Kobayashi T,Jung J,Lagae L,Milh M,Mathieu ML,Minassian BA,Novelli A,Pietrafusa N,T

更新日期：2020-07-01 00:00:00

abstract：:Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the...

journal_title：Epilepsia

authors： Bartolomei F,Lagarde S,Wendling F,McGonigal A,Jirsa V,Guye M,Bénar C

更新日期：2017-07-01 00:00:00

abstract：:The practice of epileptology at a molecular level, where gene products are identified by gene mapping, will soon be possible for a growing number of epilepsies. Juvenile myoclonic epilepsy (JME) is the first of such epilepsies to be mapped to a chromosome, namely chromosome 6p21.3. Family studies of 68 JME probands fr...

journal_title：Epilepsia

authors： Delgado-Escueta AV,Greenberg DA,Treiman L,Liu A,Sparkes RS,Barbetti A,Park MS,Terasaki PI

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The need for alternative pharmacologic strategies in treatment of epilepsies is pressing for about 30% of patients with epilepsy who do not experience satisfactory seizure control with present treatments. In temporal lobe epilepsy (TLE) even up to 80% of patients are pharmacoresistant, and surgical resection ...

journal_title：Epilepsia

authors： Klaft ZJ,Hollnagel JO,Salar S,Calişkan G,Schulz SB,Schneider UC,Horn P,Koch A,Holtkamp M,Gabriel S,Gerevich Z,Heinemann U

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Patients with gliomas frequently present with seizures, but the factors associated with seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested the contribution of aberrant glutamate release from gliomas on glioma-asso...

journal_title：Epilepsia

authors： Campbell SL,Buckingham SC,Sontheimer H

更新日期：2012-08-01 00:00:00

abstract：AIM:To trace the concept that the cerebral cortex is the site of epileptogenesis before Hughlings Jackson published the idea in 1870 in the paper "A study of convulsions" which marks the beginning of modern epileptology. METHOD:Perusal of 19th century English language medical literature. RESULT:The existence of corti...

journal_title：Epilepsia

authors： Eadie MJ

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To examine which variables available early in the course of childhood epilepsy are associated with a poor short-term outcome and to develop models to predict such an outcome. METHODS:We prospectively followed up 466 children with newly diagnosed epilepsy for 2 years. Variables were collected at intake and afte...

journal_title：Epilepsia

authors： Arts WF,Geerts AT,Brouwer OF,Boudewyn Peters AC,Stroink H,van Donselaar CA

更新日期：1999-06-01 00:00:00

abstract：:Epilepsy is a disease of complex etiology, and multiple molecular mechanisms contribute to its development. Temporal lobe epilepsy (TLE) may result from an initial precipitating event such as hypoxia, head injury, or prolonged seizure (i.e., status epilepticus [SE]), that is followed by a latent period of months to ye...

journal_title：Epilepsia

authors： Grabenstatter HL,Russek SJ,Brooks-Kayal AR

更新日期：2012-12-01 00:00:00

abstract：:We report on the cognitive-behavioral treatment of a 12-year-old boy with photogenic partial seizures with secondary generalization who had developed phobic avoidant behavior toward all kinds of situations with potential photostimulation, leading to serious impairments of life quality. Based on a behavioral analysis o...

journal_title：Epilepsia

authors： Noeker M,Haverkamp F

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Mesial temporal sclerosis (MTS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures. METHODS:We searched evidence for apoptotic cell death in temporal l...

journal_title：Epilepsia

authors： Uysal H,Cevik IU,Soylemezoglu F,Elibol B,Ozdemir YG,Evrenkaya T,Saygi S,Dalkara T

更新日期：2003-06-01 00:00:00

abstract：:A case of Rasmussen encephalitis with bilateral involvement and onset at age 2 years is reviewed. Rasmussen encephalitis is a rare progressive disease that causes intractable seizures, cognitive decline, and inflammatory changes in the brain. The neurologic involvement is characteristically unilateral. Bilateral invol...

journal_title：Epilepsia

authors： Tobias SM,Robitaille Y,Hickey WF,Rhodes CH,Nordgren R,Andermann F

更新日期：2003-01-01 00:00:00

abstract：:The treatment of status epilepticus has changed over the past five decades since the first colloquium on status epilepticus, held in Marseille in 1962. New intravenous drugs, such as valproate, levetiracetam, lacosomide or ketamine and new routes of administration, such as intranasal or bucal, as well as high-class ra...

journal_title：Epilepsia

authors： Janz D

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：:We examined EEG findings from an ongoing study of 347 children with a first unprovoked seizure. EEGs were available in 321 (93%), and 135 (42%) had an abnormal EEG. EEG abnormalities included focal spikes (n = 77), generalized spike and wave discharges (n = 28), slowing (n = 43), and nonspecific abnormalities (n = 7)....

journal_title：Epilepsia

authors： Shinnar S,Kang H,Berg AT,Goldensohn ES,Hauser WA,Moshé SL

更新日期：1994-05-01 00:00:00

abstract：:Eleven patients had seizures with unilateral temporal lobe onset recorded with simultaneous bilateral medial temporal depth electrodes and neocortical (subdural) electrodes at least on the side of seizure onset. Of a total of 55 seizures, four had simultaneous onset in neocortex and hippocampus, and 51 had onset in un...

journal_title：Epilepsia

authors： Spencer SS,Williamson PD,Spencer DD,Mattson RH

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effe...

journal_title：Epilepsia

authors： Kahriman M,Minecan D,Kutluay E,Selwa L,Beydoun A

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Presurgical language mapping in dominant hemisphere epilepsy to evaluate the risk of postoperative deficit is particularly difficult in children. Extraoperative invasive cortical stimulation can show some areas critical to language, but not all of them, due to scarce sampling, poor cooperation, cortical immatur...

journal_title：Epilepsia

authors： de Ribaupierre S,Fohlen M,Bulteau C,Dorfmüller G,Delalande O,Dulac O,Chiron C,Hertz-Pannier L

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States. METHODS:Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyze...

journal_title：Epilepsia

authors： Faught E,Laliberté F,Wang Z,Barghout V,Haider B,Lejeune D,Germain G,Choi J,Wagh A,Duh MS

更新日期：2017-10-01 00:00:00

abstract：:The pharmacokinetics of antiepileptic drugs have been investigated extensively during the last two decades. It has become evident that the therapeutic management of epileptic patients would be significantly improved with the elimination of the drawbacks associated with existing antiepileptic drugs. Based on the inform...

journal_title：Epilepsia

authors： Levy RH,Kerr BM

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Adult epilepsy studies have demonstrated cerebral and cerebellar volume reduction beyond the epileptogenic zone, correlating this with an inferior surgical outcome. We determined whether brain volumes were reduced in childhood epilepsy and the significance of this. METHODS:Cerebral, cerebellar, and hippocampal...

journal_title：Epilepsia

authors： Lawson JA,Vogrin S,Bleasel AF,Cook MJ,Bye AM

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To systematically review the methodology and use of neuropsychological tests in randomized controlled trials (RCTs) of antiepileptic drugs (AEDs) in patients with epilepsy. METHODS:Trial reports were found by searching Medline 1966-1996 and searching through journals by hand. Inclusion and exclusion criteria w...

journal_title：Epilepsia

authors： Cochrane HC,Marson AG,Baker GA,Chadwick DW

更新日期：1998-10-01 00:00:00

abstract：:We studied 36 drop seizures in 5 patients with myoclonic astatic epilepsy of early childhood (MAEE) with simultaneous split-screen video recording and polygraph. Sixteen were falling attacks and 20 were either less severe attacks exhibiting only deep head nodding or seizures equivalent to drop attacks in terms of icta...

journal_title：Epilepsia

authors： Oguni H,Fukuyama Y,Imaizumi Y,Uehara T

更新日期：1992-09-01 00:00:00

abstract：:Impaired consciousness in epilepsy has a major negative impact on quality of life. Prior work suggests that complex partial seizures (CPS) and generalized tonic-clonic seizures (GTCS), which both cause loss of consciousness, affect similar frontoparietal networks. Milder involvement in CPS than in GTCS may spare some ...

journal_title：Epilepsia

authors： McPherson A,Rojas L,Bauerschmidt A,Ezeani CC,Yang L,Motelow JE,Farooque P,Detyniecki K,Giacino JT,Blumenfeld H

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：:Ten infantile spasms (IS) patients had single photon emission computed tomography (SPECT) with [99mTc]HMPAO, EEG, and magnetic resonance imaging (MRI) studies. SPECT showed localized cerebral hypoperfusion in 7 infants (4 unifocal; 3 multifocal) always involving the temporal regions either unilaterally or bilaterally....

journal_title：Epilepsia

authors： Miyazaki M,Hashimoto T,Fujii E,Tayama M,Kuroda Y

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Autoantibodies against glutamic acid decarboxylase (GAD) and the voltage-gated potassium channel (VGKC) complex are associated with distinct subtypes of limbic encephalitis regarding clinical presentation, response to therapy, and outcome. The aim of this study was to investigate white matter changes in these...

journal_title：Epilepsia

authors： Wagner J,Schoene-Bake JC,Witt JA,Helmstaedter C,Malter MP,Stoecker W,Probst C,Weber B,Elger CE

更新日期：2016-03-01 00:00:00

abstract：:Identical twins concordant for partial epilepsy, with onset at 8 and 11 years of age, are presented. Their course has been benign on anticonvulsant therapy. It is suggested that these cases of presumed genetic epilepsy support current concepts of cortical origin and genetic determinants in several subtypes of focal ep...

journal_title：Epilepsia

authors： Hurst R,Lenn NJ

更新日期：1986-03-01 00:00:00