Induction of new carbonic anhydrase II following treatment with acetazolamide in DBA and C57 mice.

abstract：PURPOSE:Exposure to toxic levels of organophosphorus (OP) nerve agents can lead to seizures, respiratory failure, and, if untreated, death. The cholinesterase inhibitor soman belongs to the class of OP nerve agents and can cause status epilepticus (SE) and brain damage due to neuroexcitotoxicity. In the present study, ...

journal_title：Epilepsia

authors： de Araujo Furtado M,Lumley LA,Robison C,Tong LC,Lichtenstein S,Yourick DL

更新日期：2010-08-01 00:00:00

abstract：:Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women ...

journal_title：Epilepsia

authors： Duncan S,Mercho S,Lopes-Cendes I,Seni MH,Benjamin A,Dubeau F,Andermann F,Andermann E

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:The cardiac component of risk for sudden unexpected death in epilepsy (SUDEP) and alterations in cardiac risk by vagus nerve stimulation (VNS) are not well understood. We determined changes in T-wave alternans (TWA), a proven noninvasive marker of risk for sudden cardiac death in patients with cardiovascular ...

journal_title：Epilepsia

authors： Schomer AC,Nearing BD,Schachter SC,Verrier RL

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...

journal_title：Epilepsia

authors： Nail-Boucherie K,Lê-Pham BT,Gobaille S,Maitre M,Aunis D,Depaulis A

更新日期：2005-01-01 00:00:00

abstract：:1-Phenylcyclohexylamine (PCA) and its analogues 1-phenylcyclopentylamine (PPA) and 1-(3-fluorophenyl)cyclohexylamine (3-F-PCA) are potent anticonvulsants in the mouse maximal electroshock (MES) seizure test. Unlike the structurally related dissociative anesthetic phencyclidine (PCP), however, which produces motor toxi...

journal_title：Epilepsia

authors： Blake PA,Yamaguchi S,Thurkauf A,Rogawski MA

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To explore the structure-function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). METHODS:Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based ...

journal_title：Epilepsia

authors： Fosi T,Chu C,Chong WK,Clark C,Scott RC,Boyd S,De Haan M,Neville B

更新日期：2015-04-01 00:00:00

abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...

journal_title：Epilepsia

authors： Jayakar P,Gotman J,Harvey AS,Palmini A,Tassi L,Schomer D,Dubeau F,Bartolomei F,Yu A,Kršek P,Velis D,Kahane P

更新日期：2016-11-01 00:00:00

abstract：:We present a technique for automatic detection of epileptic spikes in electroencephalogram (EEG) recordings. We used a nonlinear modeling method that enables us to detect rapidly and accurately epileptic behavior in the EEG signal. Our approach is illustrated by an application to interictal activity from a patient wit...

journal_title：Epilepsia

authors： Diambra L

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To develop an epilepsy-specific comorbidity risk adjustment index for mortality outcomes research. METHODS:Data were extracted from five linked administrative databases in Calgary, Canada from April 1, 1996 to March 31, 2004. Epilepsy patients were defined using a validated ICD-9-CM- and ICD-10-CA-based case d...

journal_title：Epilepsia

authors： St Germaine-Smith C,Liu M,Quan H,Wiebe S,Jette N

更新日期：2011-12-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：:Kindling of the cingulate cortex in the Senegalese baboon Papio papio led to a protracted nonconvulsive seizure state characterized by immobile staring with (anterior cingulate, AC) or without (posterior cingulate, PC) widening of eyelids and neck flexion, followed by postictal visual searching behavior. Despite early...

journal_title：Epilepsia

authors： Wada JA,Tsuchimochi H

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model for murine absence seizures, after gamma-aminobutyric acid (GABA)(B) modulation. METHODS:The animals were first tested with the GABA(B) agonist l-baclofen followed by the GABA(B) antagonist SCH 50911. ...

journal_title：Epilepsia

authors： Marrosu F,Santoni F,Fà M,Puligheddu M,Barberini L,Genugu F,Frau R,Manunta M,Mereu G

更新日期：2006-03-01 00:00:00

abstract：:The feasibility of automated detection of cortical-onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmaco...

journal_title：Epilepsia

authors： Osorio I,Frei MG,Lozano AM,Wennberg R

更新日期：2015-10-01 00:00:00

abstract：:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges (SWD) on the E...

journal_title：Epilepsia

authors： Dedeurwaerdere S,Vonck K,Van Hese P,Wadman W,Boon P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The goal of the study was to assess the health-related quality of life (HRQOL) of persons with epilepsy (PWE) by using the short form survey 36 (SF-36), to compare it with that of a control group and to detect factors influencing it. METHODS:We collected clinical and demographic data and information on health ...

journal_title：Epilepsia

authors： Mrabet H,Mrabet A,Zouari B,Ghachem R

更新日期：2004-07-01 00:00:00

abstract：:Scrub typhus is an emerging infection, and there is little information about status epilepticus (SE) in scrub typhus. We report the clinical spectrum and outcome of SE in scrub typhus. In a 3-year prospective hospital-based observational study, all scrub typhus patients with SE were included. Scrub typhus was diagnose...

journal_title：Epilepsia

authors： Kalita J,Mani VE,Bhoi SK,Misra UK

更新日期：2016-07-01 00:00:00

abstract：:It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time point...

journal_title：Epilepsia

authors： Fatuzzo D,Novy J,Rossetti AO

更新日期：2018-07-01 00:00:00

abstract：:The effect of short-term withdrawal of antiepileptic drugs (AEDs) on auditory event-related potentials (ERPs) was studied in 16 patients undergoing preoperative evaluation for epilepsy surgery. ERPs were performed for all patients during treatment with full medication and after a 1-week period during ongoing tapering ...

journal_title：Epilepsia

authors： Tuunainen A,Nousiainen U,Pilke A,Mervaala E,Riekkinen P

更新日期：1995-03-01 00:00:00

abstract：:Management of epilepsy in the elderly requires understanding of the unique biochemical and pharmacologic characteristics of this patient population. Accurate assessment of seizures and identification of epilepsy syndromes, thorough neurologic assessment to define etiology, and comprehensive evaluation of the patient's...

journal_title：Epilepsia

authors： Willmore LJ

更新日期：1995-01-01 00:00:00

abstract：:Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies ha...

journal_title：Epilepsia

authors： Nicita F,Ruggieri M,Polizzi A,Mauceri L,Salpietro V,Briuglia S,Papetti L,Ursitti F,Grosso S,Tarani L,Segni M,Savasta S,Parisi P,Verrotti A,Spalice A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of antiepileptic drugs (AEDs; oxcarbazepine [OXC], levetiracetam [LEV], and lamotrigine [LTG]) on semen quality, sexual function, and sex hormones in male adults with epilepsy. METHODS:Individual treatment with OXC, LEV, or LTG was randomly assigned to 38 newly diagnosed male adult...

journal_title：Epilepsia

authors： Wu D,Chen L,Ji F,Si Y,Sun H

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS:The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic dis...

journal_title：Epilepsia

authors： Jefferys JG

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Children with rolandic spikes may or may not have seizures, ranging from benign rolandic epilepsy to severe atypical rolandic epilepsy. We investigated whether ripples (80-250 Hz), superimposed on rolandic spikes in surface electroencephalography (EEG), can differentiate between different entities. METHODS:I...

journal_title：Epilepsia

authors： van Klink NE,van 't Klooster MA,Leijten FS,Jacobs J,Braun KP,Zijlmans M

更新日期：2016-07-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of multiple subpial transection (MST), a new technique in epilepsy surgery, alone and in combination with resection. METHODS:MST was performed in 22 patients with intractable epilepsy, 10 of whom were treated with a combination of a resection and MST in functionally important ...

journal_title：Epilepsia

authors： Hufnagel A,Zentner J,Fernandez G,Wolf HK,Schramm J,Elger CE

更新日期：1997-06-01 00:00:00

abstract：:Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

journal_title：Epilepsia

authors： Cho KH,Cho YJ,Lee BI,Heo K

更新日期：2016-08-01 00:00:00

abstract：:The development of the Neuropsychological Battery for Epilepsy is presented. The tests are designed to be helpful in the evaluation of adult epileptics. The battery consists of General Measures which include tests in the areas of intellectual functioning, emotional status, and lateral dominance. The development of a s...

journal_title：Epilepsia

authors： Dodrill CB

更新日期：1978-12-01 00:00:00

abstract：PURPOSE:To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. METHODS:A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical I...

journal_title：Epilepsia

authors： Mady MA,Kossoff EH,McGregor AL,Wheless JW,Pyzik PL,Freeman JM

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. METHODS:Repeated, low-dose (5 mg/kg), intraperito...

journal_title：Epilepsia

authors： Grabenstatter HL,Dudek FE

更新日期：2008-10-01 00:00:00