Abstract:
:Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women taking moderate doses of VPA who repeatedly bore children with neural tube defects, despite folate supplementation. This suggests a pharmacogenetic susceptibility to the teratogenic effects of VPA.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Duncan S,Mercho S,Lopes-Cendes I,Seni MH,Benjamin A,Dubeau F,Andermann F,Andermann Edoi
10.1046/j.1528-1157.2001.44300.xsubject
Has Abstractpub_date
2001-06-01 00:00:00pages
750-3issue
6eissn
0013-9580issn
1528-1167pii
epi44300journal_volume
42pub_type
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