Abstract:
:Generalized epilepsies are treatable with a number of antiepileptic drugs (AEDs) that are effective in different seizure types and epilepsy syndromes. The mechanisms of action of these AEDs are incompletely understood but include inhibition of low-threshold calcium currents and of voltage-gated sodium channels and facilitation of GABA(A) receptor currents. The mechanisms of aggravation are also unknown but could include elevation of brain GABA, blockade of voltage-gated sodium channels, and idiosyncratic toxicity reactions. Anecdotal reports suggest that aggravation of generalized epilepsy can occur with virtually all AEDs. The best-documented examples are aggravation of absences by carbamazepine and aggravation of symptomatic generalized epilepsies by vigabatrin. Therefore, the physician must be constantly aware of the problem of aggravation of seizures by AEDs. With careful diagnosis of the epileptic syndrome and an awareness of the problem, aggravation of seizures can be minimized.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Berkovic SFdoi
10.1111/j.1528-1157.1998.tb05115.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
S11-4eissn
0013-9580issn
1528-1167journal_volume
39 Suppl 3pub_type
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