WONOEP appraisal: optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis.

abstract：OBJECTIVE:Whether magnetic resonance imaging (MRI) is informative in febrile seizures (FS) is unknown. We undertook a study to determine the frequency of MRI-detected brain abnormalities and to evaluate their association with FS type and with specific features of complex FS. METHODS:A prospective cohort study, from 19...

journal_title：Epilepsia

authors： Hesdorffer DC,Chan S,Tian H,Allen Hauser W,Dayan P,Leary LD,Hinton VJ

更新日期：2008-05-01 00:00:00

abstract：:Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

journal_title：Epilepsia

authors： Rodin EA,Katz M,Lennox K

更新日期：1976-09-01 00:00:00

abstract：:Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women ...

journal_title：Epilepsia

authors： Duncan S,Mercho S,Lopes-Cendes I,Seni MH,Benjamin A,Dubeau F,Andermann F,Andermann E

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...

journal_title：Epilepsia

authors： Ahmadiani A,Mandgary A,Sayyah M

更新日期：2003-05-01 00:00:00

abstract：:Ketogenic diets (KDs) are designed to create the metabolic conditions of fasting, which was among the earliest therapies discovered for epilepsy. The major measures used to evaluate dietary effectiveness have been the levels of urinary ketone bodies and the successful reduction of seizure activity. Modifications of th...

journal_title：Epilepsia

authors： Eagles DA

更新日期：2008-11-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：:Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has be...

journal_title：Epilepsia

authors： Covanis A,Gupta AK,Jeavons PM

更新日期：1982-12-01 00:00:00

abstract：PURPOSE:To determine the prevalence, manifestations, lateralizing value, and surgical prognostic value of somatosensory auras (SSAs) in patients with refractory temporal lobe epilepsy (TLE). METHODS:Eighty-one consecutive patients undergoing temporal lobectomy for refractory complex-partial seizures were screened for ...

journal_title：Epilepsia

authors： Erickson JC,Clapp LE,Ford G,Jabbari B

更新日期：2006-01-01 00:00:00

abstract：:Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video-EEG recording of both spontaneous and suggestion-induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using sal...

journal_title：Epilepsia

authors： Bazil CW,Kothari M,Luciano D,Moroney J,Song S,Vasquez B,Weinreb HJ,Devinsky O

更新日期：1994-07-01 00:00:00

abstract：:The tendency for four strains of parathyroidectomized (PTx) rats to convulse after pinealectomy (Px) was observed in this experiment; telencephalic serotonin, norepinephrine, and dopamine were examined to note any correlation between amines and convulsions. The strains of rats tested were Sprague-Dawley, Wistar, Long-...

journal_title：Epilepsia

authors： Philo R,Reiter RJ

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:The present study aimed to clarify the effect of electrical stimulation and lesioning of the anterior nucleus of the thalamus (ANT) on kainic acid (KA)-induced focal cortical seizures in a rat model. To address the mechanism underlying these anticonvulsant actions, cerebral glucose metabolism after ANT electric...

journal_title：Epilepsia

authors： Takebayashi S,Hashizume K,Tanaka T,Hodozuka A

更新日期：2007-02-01 00:00:00

abstract：:We analyzed the results of neuroimaging studies in patients with periodic lateralized epileptiform discharges (PLEDs) or bilateral independent periodic lateralized epileptiform discharges (BIPLEDs) for localization of lesions in gray or white matter to determine if "cortical isolation" is a critical mechanism in the p...

journal_title：Epilepsia

authors： Raroque HG Jr,Purdy P

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To determine if the clinical characteristics of nonepileptic seizures (NES) are different in children younger than 13 years age as compared to adolescents. METHODS:Retrospective review of medical records and video-EEGs (VEEG) of all patients with NES confirmed on VEEG monitoring was performed. RESULTS:Sixty-e...

journal_title：Epilepsia

authors： Patel H,Scott E,Dunn D,Garg B

更新日期：2007-11-01 00:00:00

abstract：:Seizures, epilepsy, and alcohol are complexly interrelated. Although it is commonly perceived that patients with epilepsy experience problems with seizure control if they use alcohol, this is not confirmed by the few experimental studies that have tested the hypothesis. The last 30 years have emphasized the role of wi...

journal_title：Epilepsia

authors： Hauser WA,Ng SK,Brust JC

更新日期：1988-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans....

journal_title：Epilepsia

authors： Christensen J

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide ...

journal_title：Epilepsia

authors： Mula M,McGonigal A,Micoulaud-Franchi JA,May TW,Labudda K,Brandt C

更新日期：2016-06-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) is noninvasive and may be readily combined with magnetic resonance imaging (MRI). Attention has focussed on proton (1H) and phosphorus (31P) MRS, and studies have been undertaken by using single voxels or many voxels simultaneously (chemical-shift imaging, magnetic resonance spect...

journal_title：Epilepsia

authors： Duncan JS

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:Febrile seizures (FS) are the most common type of convulsive events in children. FS are suggested to result from a combination of genetic and environmental factors. However, the pathophysiologic mechanisms underlying FS remain unclear. Using an animal model of experimental FS, it was demonstrated that hyperther...

journal_title：Epilepsia

authors： Schuchmann S,Hauck S,Henning S,Grüters-Kieslich A,Vanhatalo S,Schmitz D,Kaila K

更新日期：2011-11-01 00:00:00

abstract：:Severe early onset epilepsies are often caused by de novo pathogenic variants. Few studies have reported the frequency of somatic mosaicism in parents of children with severe epileptic encephalopathies. Here we aim to investigate the frequency of mosaicism in the parents of children with epilepsy caused by alleged de ...

journal_title：Epilepsia

authors： Møller RS,Liebmann N,Larsen LHG,Stiller M,Hentschel J,Kako N,Abdin D,Di Donato N,Pal DK,Zacher P,Syrbe S,Dahl HA,Lemke JR

更新日期：2019-06-01 00:00:00

abstract：:Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...

journal_title：Epilepsia

authors： Stefan H,Schäfer H,Kuhnen C,Schneider S

更新日期：1988-09-01 00:00:00

abstract：:The antiepileptic drug sodium valproate (VPA) can provoke a thrombocytopenia or platelet dysfunction, with or without hemorrhages. These unwanted side effects are probably infrequent or, at least, have little clinical importance except in patients undergoing surgery. Thromboelastography appears to be a reliable screen...

journal_title：Epilepsia

authors： Loiseau P

更新日期：1981-04-01 00:00:00

abstract：:Clinical trials of antiepileptic drugs (AEDs) are usually performed only in major teaching centers, thus ignoring the very real contribution available from private practice. The relation between the consultant and the referring family physician is often much closer in private practice, allowing much earlier recruitmen...

journal_title：Epilepsia

authors： Beran RG,Tilley M

更新日期：1994-01-01 00:00:00

abstract：:Standard antiepileptic drugs (AEDs) are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management. The safety and interaction profiles of the newer AEDs have also been intensively studied. Safety data are available...

journal_title：Epilepsia

authors： Shorvon S,Stefan H

更新日期：1997-01-01 00:00:00

abstract：:We report identical twins with supernumerary ring chromosome 19 mosaicism, who had severe refractory epilepsy at an early age. The epilepsy was dominated largely by severe life-threatening tonic seizures. Both twins died, likely as a consequence of their severe epilepsy. They displayed no dysmorphic features. Eight ca...

journal_title：Epilepsia

authors： Shahwan A,Green AJ,Carey A,Stallings RL,O'Flaherty OC,King MD

更新日期：2004-08-01 00:00:00

abstract：:Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor (dissociation constant, KD, of 3 nM) linked to the GABAA recognition site enhances the inhibitory action of GABA by increasing the number of openings of Cl- ch...

journal_title：Epilepsia

authors： Meldrum BS,Chapman AG

更新日期：1986-01-01 00:00:00

abstract：:The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiep...

journal_title：Epilepsia

authors： Wheless JW,Treiman DM

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Uncontrolled epilepsy remains a significant health concern and requires new approaches to therapy. N-methyl-d-aspartate (NMDA) receptor blockade has been considered, but the adverse cognitive and behavioral effects of conventional NMDA-receptor antagonists have prevented the development of clinically useful com...

journal_title：Epilepsia

authors： Zhang DX,Williamson JM,Wu HQ,Schwarcz R,Bertram EH

更新日期：2005-11-01 00:00:00

abstract：:Men are different from women, and patients with epilepsy are different in many aspects from healthy control subjects. Quantitative or semiquantitative analysis of neuroimaging data depends on the comparison between either a single patient against a group of healthy or unaffected controls, or comparisons between groups...

journal_title：Epilepsia

authors： Koepp MJ

更新日期：2011-07-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:  Vagus nerve stimulation (VNS) provides partial relief of medically refractory partial seizures in a subset of patients. The optimal pattern of stimulation and the mechanism of the antiseizure effects are uncertain. Establishing the efficacy of VNS in an animal model of epilepsy would provide an experimental p...

journal_title：Epilepsia

authors： Alexander GM,McNamara JO

更新日期：2012-11-01 00:00:00