Abstract:
OBJECTIVE:To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. METHODS:A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. RESULTS:Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. SIGNIFICANCE:Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Nash TE,Mahanty S,Loeb JA,Theodore WH,Friedman A,Sander JW,Singh G,Cavalheiro E,Del Brutto OH,Takayanagui OM,Fleury A,Verastegui M,Preux PM,Montano S,Pretell EJ,White AC Jr,Gonzales AE,Gilman RH,Garcia HHdoi
10.1111/epi.12849subject
Has Abstractpub_date
2015-02-01 00:00:00pages
177-83issue
2eissn
0013-9580issn
1528-1167journal_volume
56pub_type
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