Abstract:
PURPOSE:To characterize features influencing marital status in a group of patients with refractory epilepsy before and after epilepsy surgery and to assess the effect of seizure control on marital status after epilepsy surgery. METHODS:We analyzed marital status in 430 epilepsy surgery patients and in a subset with temporal lobe epilepsy. Marital status was assessed in relation to gender and age of epilepsy onset and compared with marital rates for the U.S. population. Patients who had > or =4 years of postsurgical follow-up were examined for change in marital status after surgery. Those patients who changed marital status were then evaluated for change in employment. RESULTS:Marital rates were lower than expected in men. Men with onset of epilepsy by age 11 years were less likely to be married than men whose seizures began after age 11 or women whose seizures began at any age. Men and women with temporal lobe epilepsy had higher marriage rates than those with extratemporal lobe epilepsy. More than 4 years after epilepsy surgery (n = 190), patients who had no recurrent seizures were more likely to change marital status (28 of 124, 23%), than those who had recurrent seizures (five of 66, 8%). Seizure-free women were more likely to divorce (n = 9) than were seizure-free men (n = 1). Most men who married were employed (77%), whereas women who divorced were usually unemployed (67%). CONCLUSIONS:The age at which seizures begin influences later marital status in men, who have reduced marriage rates. The abolition of seizures by epilepsy surgery creates new opportunities for changing social relationships. Location of the epileptic focus may influence psychosocial function.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Carran MA,Kohler CG,O'Connor MJ,Cloud B,Sperling MRdoi
10.1111/j.1528-1157.1999.tb01594.xsubject
Has Abstractpub_date
1999-12-01 00:00:00pages
1755-60issue
12eissn
0013-9580issn
1528-1167journal_volume
40pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract:PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01686.x
更新日期:2008-11-01 00:00:00
abstract::Steady-state plasma antiepileptic drug (AED) concentrations were measured at intervals throughout pregnancy and during the postnatal period in 105 women who underwent 134 pregnancies. Phenytoin (PHT) dosage had to be increased in 85% of pregnancies in which the drug was received, carbamazepine (CBZ) dosage in 70%, and...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb05253.x
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:We investigated the incidence of well-directed violent behavior and suicide attempts in patients with temporal lobe epilepsy, with special attention to postictal psychosis. METHODS:We compared 57 episodes of postictal psychosis with 62 episodes of acute interictal (or alternative) psychosis and with 134 comple...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb01996.x
更新日期:1999-01-01 00:00:00
abstract::The possibility of sudden unexpected death in epilepsy (SUDEP) should affect the management of virtually every patient with proven or suspected epilepsy by (a) underlining the need to make all reasonable efforts to render each patient seizure-free; (b) emphasizing the importance of minimizing avoidable seizures; (c) b...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1997.tb06131.x
更新日期:1997-11-01 00:00:00
abstract::Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12804
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:Precipitants of seizures are often reported by patients and carers, but the accuracy of these claims remains unknown. Focusing on epilepsy in people with intellectual disability (ID), the aims of this work were to (1) identify a set of methods for assessing the validity of reported seizure triggers in indivi...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13137
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13977
更新日期:2018-02-01 00:00:00
abstract::The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progeste...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12969
更新日期:2015-05-01 00:00:00
abstract::The teratological effect of nicotine has been studied during different trimesters of pregnancy. Three groups of pregnant albino Swiss mice were used for each trimester. The daily doses of nicotine base used were equivalent to 10 (900 micrograms/kg), 20 (1,800 micrograms/kg), or 30 (2,700 micrograms/kg) cigarettes. The...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1985.tb05708.x
更新日期:1985-11-01 00:00:00
abstract::The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1988.tb03745.x
更新日期:1988-07-01 00:00:00
abstract::The efficacy and the potential risk of inducing convulsive or nonconvulsive status epilepticus with the combination of valproate (VPA) and clonazepam (CZP), with or without other anticonvulsant drugs, in 55 patients with intractable epilepsy was evaluated. The patients were treated with VPA and CZP concomitantly for f...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1985.tb05394.x
更新日期:1985-03-01 00:00:00
abstract::Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immun...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb05622.x
更新日期:1991-01-01 00:00:00
abstract::Sleep and epilepsy are interrelated. Understanding the relationship between epilepsy and sleep is important for optimizing management of the epilepsy patient in several ways. First, sleep modulates the expression of epileptic seizures and interictal epileptiform discharges. Second, epilepsy and its treatment influence...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2007.01400.x
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1997.tb01254.x
更新日期:1997-08-01 00:00:00
abstract::Use of antiepileptic drugs (AEDs) in pregnant women with epilepsy (WWE) is associated with an increased risk of major congenital malformations (MCM). Previous studies have suggested that WWE who had a malformation in their index pregnancy were at an increased risk of recurrence in future pregnancies. We aimed to asses...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12411
更新日期:2013-12-01 00:00:00
abstract::All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb02343.x
更新日期:1992-07-01 00:00:00
abstract:PURPOSE:To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. METHODS:Twelve patients with epilepsy stabilized on PHT monotherapy were enrolled in this st...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.41701.x
更新日期:2002-07-01 00:00:00
abstract::The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact o...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.12295
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.34301.x
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:To evaluate the changes in serum sex hormones of gonadal or adrenal origin, the gonadotropic hormones, and sex hormone-binding globulin (SHBG) in men and women with chronic temporal lobe epilepsy (TLE), who are undergoing monotherapy with carbamazepine or receiving carbamazepine in combination with other antico...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1998.tb01307.x
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:To study the course and outcome of childhood-onset epilepsy during 15-year follow-up (FU). METHODS:We extended FU in 413 of 494 children with new-onset epilepsy recruited in a previously described prospective hospital-based study by questionnaire. RESULTS:Mean FU was 14.8 years (range 11.6-17.5 years). Five-y...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2010.02546.x
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00518.x
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01864.x
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged. In particular, mice that overexpress alpha 1b-AR undergo spontaneous epileptic seizures and progressive neuronal loss in a variety of brain areas. There...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01972.x
更新日期:2009-01-01 00:00:00
abstract::Forty-five outpatients with chronic epilepsy with complex partial seizures (CPS) alone or associated with secondarily generalized tonic-clonic seizures (SGTCS) were treated with carbamazepine (CBZ) monotherapy. All patients had only a unilateral scalp electroencephalographic (EEG) focus. Left- (n = 29) and right- (n =...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb04713.x
更新日期:1991-09-01 00:00:00
abstract:SUMMARY:First-time seizure and status epilepticus during pregnancy have been previously reported as the initial manifestation of intracranial cavernous hemangioma. We report a woman with no history of seizures who presented with refractory status epilepticus at 10 weeks gestation. Cranial MRI revealed a right frontal c...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01639.x
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To estimate magnetoencephalography (MEG) correlates of different types of aura in temporal lobe epilepsy (TLE). METHODS:MEG study was performed on 57 patients (26 male and 31 female) with TLE, whose ages ranged from 14-46 years (mean 27 years). Interictal magnetoencephalograms showing discharges were analyzed,...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2010.02655.x
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2003.36402.x
更新日期:2003-05-01 00:00:00
abstract::Early in these proceedings, the origin of the three terms in the title, "idiopathic generalized epilepsy," is discussed with respect to their significance over time, and typical misunderstandings. In the mid-20th century, a rather chaotic use of a multitude of often loosely defined terms had developed, which increasin...
journal_title:Epilepsia
pub_type: 历史文章,杂志文章
doi:10.1111/j.1528-1167.2005.00308.x
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2005.00336.x
更新日期:2005-12-01 00:00:00