Plasma antiepileptic drug concentrations during pregnancy.

abstract：:Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...

journal_title：Epilepsia

authors： Zhang CL,Gloveli T,Heinemann U

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To evaluate the demographic impact of epilepsy a rural area of Africa. METHODS:A cohort study was conducted between 1991 and 2001 in the Mbam Valley (Cameroon) on two groups of subjects (one of persons with epilepsy, and the other of control individuals matched for sex, age, and village of residence). At the e...

journal_title：Epilepsia

authors： Kamgno J,Pion SD,Boussinesq M

更新日期：2003-07-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To determine the incidence, duration, risk factors for, and clinical correlates of postictal generalized electroencephalography (EEG) suppression (PGES), and to further delineate the significance of PGES in the pathogenesis of sudden unexpected death in epilepsy (SUDEP). METHODS:We retrospectively reviewed the...

journal_title：Epilepsia

authors： Tao JX,Yung I,Lee A,Rose S,Jacobsen J,Ebersole JS

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...

journal_title：Epilepsia

authors： Kim HD,Clancy RR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Polymicrogyria (PMG) is an epileptogenic malformation of cortical development. We describe the clinical epilepsy and imaging features of a large cohort with PMG-related epilepsy. METHODS:Participants were recruited through the Epilepsy Phenome/Genome Project, a multicenter collaborative effort to collect detai...

journal_title：Epilepsia

authors： Shain C,Ramgopal S,Fallil Z,Parulkar I,Alongi R,Knowlton R,Poduri A,EPGP Investigators.

更新日期：2013-08-01 00:00:00

abstract：:Studies from several countries have reported that fewer people with epilepsy marry, but the reasons for this are not clear. In the present investigation, 178 adults with epilepsy were divided into married, separated/divorced, and never married groups. The never married group was subdivided into persons living in depen...

journal_title：Epilepsia

authors： Batzel LW,Dodrill CB

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:Benign rolandic epilepsy (BRE) is considered a genetically determined idiopathic partial epilepsy. We analyzed a large sample of twins from four international twin registers to probe the genetics of BRE. We also aim to synthesize the apparently conflicting family and twin data into a model of BRE etiology. MET...

journal_title：Epilepsia

authors： Vadlamudi L,Kjeldsen MJ,Corey LA,Solaas MH,Friis ML,Pellock JM,Nakken KO,Milne RL,Scheffer IE,Harvey AS,Hopper JL,Berkovic SF

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...

journal_title：Epilepsia

authors： Nail-Boucherie K,Lê-Pham BT,Gobaille S,Maitre M,Aunis D,Depaulis A

更新日期：2005-01-01 00:00:00

abstract：:This study evaluated ictal stereotaxic electroencephalogram (SEEG) records in 75 patients with complex partial seizures who later received anterior temporal lobectomy and were evaluated for long-term seizure relief. The time required for seizures to propagate from the putatively epileptogenic hippocampal formation to ...

journal_title：Epilepsia

authors： Lieb JP,Engel J Jr,Babb TL

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RE...

journal_title：Epilepsia

authors： Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...

journal_title：Epilepsia

authors： O'Neill J,Seese R,Hudkins M,Siddarth P,Levitt J,Tseng PB,Wu KN,Gurbani S,Shields WD,Caplan R

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-19...

journal_title：Epilepsia

authors： Berg AT,Shinnar S,Levy SR,Testa FM

更新日期：1999-04-01 00:00:00

abstract：:The duration of epilepsy was evaluated in over 460 previously untreated patients who attended newly established epilepsy clinics in a rural area of Malawi. The mean duration at first attendance was 6.5 years. It was found that as the duration of active epilepsy increased, the number of patients having epilepsy of a gi...

journal_title：Epilepsia

authors： Watts AE

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Several experimental paradigms of seizure induction that produce epilepsy as a consequence have been shown to be associated with the proliferation of dentate granule cells. In developing animals, the acute sequela of hilar damage and the chronic sequelae of spontaneous seizures and mossy fiber synaptic reorgani...

journal_title：Epilepsia

authors： Sankar R,Shin D,Liu H,Katsumori H,Wasterlain CG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:The novel antiepileptic drug (AED) levetiracetam (LEV; Keppra) has a wide therapeutic index and pharmacokinetic characteristics predicting limited drug-interaction potential. It is indicated as an add-on treatment in patients with epilepsy, and thus coadministration with valproic acid (VPA) is likely. These stu...

journal_title：Epilepsia

authors： Coupez R,Nicolas JM,Browne TR

更新日期：2003-02-01 00:00:00

abstract：:The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

journal_title：Epilepsia

authors： Goodman JH,Homan RW,Crawford IL

更新日期：1990-09-01 00:00:00

abstract：:Presently available noninvasive methods correctly localize epileptogenic regions in only approximately 50% of patients with frontal lobe epilepsy (FLE). Earlier studies have shown that temporal lobe epileptogenic regions may be identified readily by positron emission tomography (PET) measurements of regional benzodiaz...

journal_title：Epilepsia

authors： Savic I,Thorell JO,Roland P

更新日期：1995-12-01 00:00:00

abstract：:A population study was performed to estimate the prevalence of epilepsy in the juvenile population of Valladolid, Spain. Using a mixed questionnaire (postal-domiciliary), we studied a sample of 5,100 primary school pupils (aged between 6 and 14 years) and 48 pupils receiving state-run special education. We also identi...

journal_title：Epilepsia

authors： Ochoa Sangrador C,Palencia Luaces R

更新日期：1991-11-01 00:00:00

abstract：:It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time point...

journal_title：Epilepsia

authors： Fatuzzo D,Novy J,Rossetti AO

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Structural variations disrupting the gene encoding the neuron-specific splicing regulator RBFOX1 have been reported in three patients exhibiting epilepsy in comorbidity with other neuropsychiatric disorders. Consistently, the Rbfox1 knockout mouse model showed an increased susceptibility of seizures. The presen...

journal_title：Epilepsia

authors： Lal D,Trucks H,Møller RS,Hjalgrim H,Koeleman BP,de Kovel CG,Visscher F,Weber YG,Lerche H,Becker F,Schankin CJ,Neubauer BA,Surges R,Kunz WS,Zimprich F,Franke A,Illig T,Ried JS,Leu C,Nürnberg P,Sander T,EMINet Con

更新日期：2013-02-01 00:00:00

abstract：:Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP)...

journal_title：Epilepsia

authors： Mori N,Wada JA

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Autoantibodies against glutamic acid decarboxylase (GAD) and the voltage-gated potassium channel (VGKC) complex are associated with distinct subtypes of limbic encephalitis regarding clinical presentation, response to therapy, and outcome. The aim of this study was to investigate white matter changes in these...

journal_title：Epilepsia

authors： Wagner J,Schoene-Bake JC,Witt JA,Helmstaedter C,Malter MP,Stoecker W,Probst C,Weber B,Elger CE

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. METHODS:Twelve patients with epilepsy stabilized on PHT monotherapy were enrolled in this st...

journal_title：Epilepsia

authors： Sachdeo RC,Sachdeo SK,Levy RH,Streeter AJ,Bishop FE,Kunze KL,Mather GG,Roskos LK,Shen DD,Thummel KE,Trager WF,Curtin CR,Doose DR,Gisclon LG,Bialer M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is the most common of the antiepileptic drug (AED)-resistant seizure syndromes that are remediable mostly with surgery, although a small group of patients have benign prognosis with fewer seizures. Material-specific memory impairment ...

journal_title：Epilepsia

authors： Ozkara C,Hanoğlu L,Keskinkiliç C,Yeni N,Aysal F,Uzan M,Ozyurt E,Karaağaç N

更新日期：2004-11-01 00:00:00

abstract：:Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...

journal_title：Epilepsia

authors： Stefan H,Schäfer H,Kuhnen C,Schneider S

更新日期：1988-09-01 00:00:00

abstract：PURPOSE:The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric acid (GABA) metabolism in the glutamate/glutamine cycle (GGC). Inhibition of GS results in changes of neurotransmitter release and recycling. However, little is known about the influence of GGC on neurotransmitter...

journal_title：Epilepsia

authors： Cremer CM,Bidmon HJ,Görg B,Palomero-Gallagher N,Escobar JL,Speckmann EJ,Zilles K

更新日期：2010-08-01 00:00:00

abstract：:Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...

journal_title：Epilepsia

authors： Jones JE,Bell B,Fine J,Rutecki P,Seidenberg M,Hermann B

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Epilepsy is characterized by transient alterations in brain synchronization resulting in seizures with a wide spectrum of manifestations. Seizure severity and risks for patients depend on the evolution and spread of the hypersynchronous discharges. With standard visual inspection and pattern classification, t...

journal_title：Epilepsia

authors： Donos C,Maliia MD,Dümpelmann M,Schulze-Bonhage A

更新日期：2018-03-01 00:00:00

abstract：:Generalized epilepsies are treatable with a number of antiepileptic drugs (AEDs) that are effective in different seizure types and epilepsy syndromes. The mechanisms of action of these AEDs are incompletely understood but include inhibition of low-threshold calcium currents and of voltage-gated sodium channels and fac...

journal_title：Epilepsia

authors： Berkovic SF

更新日期：1998-01-01 00:00:00