Abstract:
PURPOSE:Polymicrogyria (PMG) is an epileptogenic malformation of cortical development. We describe the clinical epilepsy and imaging features of a large cohort with PMG-related epilepsy. METHODS:Participants were recruited through the Epilepsy Phenome/Genome Project, a multicenter collaborative effort to collect detailed phenotypic data on individuals with epilepsy. We reviewed phenotypic data from participants with epilepsy and PMG. KEY FINDINGS:We identified 87 participants, 43 female and 44 male, with PMG and epilepsy. Median age of seizure onset was 3 years (range <1 month to 37 years). Most presented with focal epilepsy (87.4%), some in combination with seizures generalized from onset (23.0%). Focal seizures with dyscognitive features were most common (54.3%). Of those presenting with generalized seizure types, infantile spasms were most prevalent (45.2%). The most common topographic pattern was perisylvian PMG (77.0%), of which the majority was bilateral (56.7%). Generalized PMG presented with an earlier age of seizure onset (median age of 8 months) and an increased prevalence of developmental delay prior to seizure onset (57.1%). Of the unilateral, and asymmetric bilateral groups where PMG was more involved in one hemisphere, the majority (71.4%) of participants had seizures that lateralized to the same hemisphere as the PMG or the hemisphere with greater involvement. SIGNIFICANCE:Participants with PMG had both focal and generalized onset of seizures. Our data confirm the involvement of known topographic patterns of PMG and suggest that more extensive distributions of PMG present with an earlier age of seizure onset and increased prevalence of developmental delay prior to seizure onset.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Shain C,Ramgopal S,Fallil Z,Parulkar I,Alongi R,Knowlton R,Poduri A,EPGP Investigators.doi
10.1111/epi.12238subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1368-75issue
8eissn
0013-9580issn
1528-1167journal_volume
54pub_type
杂志文章,多中心研究相关文献
EPILEPSIA文献大全abstract:OBJECTIVE:Prenatal exposure to antiepileptic drugs (AEDs) is associated with an increased risk of cognitive dysfunction at early school age. Our aim was to investigate whether signs of adverse drug effects on brain function could be detected already during the first 2 weeks of life. METHODS:We studied prospectively 56...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13281
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE). METHODS:We analyzed the data of 70 patients with TLE and HS and 128 patients with cryptogenic TLE matched for age, sex, st...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2003.19103.x
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:To investigate whether atypical language dominance in epilepsy patients is related to localization and type of lesions. METHODS:Four hundred and forty-five epilepsy patients received bilateral Wada testing. Language was classified as left (L), right (R), bilateral-dependent (BD, speech arrest after left and ri...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.02000.x
更新日期:2009-06-01 00:00:00
abstract::Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1996.tb01818.x
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:There are limited data on the indications for the use of chronic invasive electroencephalography (EEG) monitoring (IEM) for pediatric epilepsy surgery. METHODS:We retrospectively studied 102 children who underwent intracranial monitoring to map critical cortex, localize the epileptogenic region, or resolve d...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12983
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/epi.13275
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To validate and translate the English version of the Neurologic Depression Disorders Inventory in Epilepsy (NDDI-E) into Spanish as a screening instrument for major depressive episodes (MDE) for patients with epilepsy from Argentina and Uruguay. METHODS:One hundred fifty-five consecutive outpatients with ep...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12503
更新日期:2014-02-01 00:00:00
abstract::We present a review of phenotype-genotype correlation and the genetics of photosensitivity. The photoparoxysmal response in EEG (PPR) is still one of the best paradigms for exogenously triggered brain responses based on a genetic predisposition. The definition of the PPR phenotype requires multiple, precise methodolog...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.0013-9580.2004.451008.x
更新日期:2004-01-01 00:00:00
abstract::Spontaneously epileptic rats (SER) are a double mutant (zi/zi, tm/tm) spontaneously exhibiting both tonic and absence-like seizures. We examined the long-term effects of continual intake of phenobarbital (PB) on SER as a method of assessing long-term evaluation of antiepileptic drugs (AEDs). Food pellets containing 0....
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1990.tb05353.x
更新日期:1990-01-01 00:00:00
abstract::People with epilepsy (PWEs) are often advised against participating in sports and exercise, mostly because of fear, overprotection, and ignorance about the specific benefits and risks associated with such activities. Available evidence suggests that physical exercise and active participation in sports may favorably af...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13261
更新日期:2016-01-01 00:00:00
abstract::Surgery for seizures arising from the rolandic area can be performed effectively, and accurate mapping of eloquent regions may improve seizure and functional outcome. Noninvasive cortical mapping is, however, hardly feasible in young children. We studied two children with epileptogenic focal cortical dysplasia (FCD) t...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2012.03524.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16487
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The need for alternative pharmacologic strategies in treatment of epilepsies is pressing for about 30% of patients with epilepsy who do not experience satisfactory seizure control with present treatments. In temporal lobe epilepsy (TLE) even up to 80% of patients are pharmacoresistant, and surgical resection ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13360
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1528-1157.1999.tb00780.x
更新日期:1999-06-01 00:00:00
abstract::Four groups of pregnant rats were used to study the effects of dietary supplements of folic acid (FA) alone or a mixture of FA, vitamins (Vit), and amino acids (AA) on the teratogenic effects of phenytoin (PHT). Groups A, B, and C received intraperitoneal (i.p.) injections of high-dose (75 mg/kg/day) phenytoin (PHT) b...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1989.tb05462.x
更新日期:1989-03-01 00:00:00
abstract:SUMMARY:First-time seizure and status epilepticus during pregnancy have been previously reported as the initial manifestation of intracranial cavernous hemangioma. We report a woman with no history of seizures who presented with refractory status epilepticus at 10 weeks gestation. Cranial MRI revealed a right frontal c...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01639.x
更新日期:2008-09-01 00:00:00
abstract::Our study investigated public attitudes toward epilepsy, and knowledge and understanding of epilepsy in Hungary. We compared changes of public attitudes in the last six years, hypothesizing a trend of positive changes because of recent national initiatives for acceptance and integration of people with epilepsy (e.g., ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2001.18000.x
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:Magnetic resonance imaging (MRI) is an essential diagnostic tool for the management of epilepsy at modern epilepsy clinics. This study was conducted to incorporate MRI features into the international classification of epilepsies and epilepsy syndromes (ICEES) proposed by the International League Against Epileps...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.32901.x
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To describe seizure control, complications, adaptive function and language skills following hemispheric surgery for epilepsy. METHODS:Retrospective chart review of patients who underwent hemispheric surgery from July 1993 to June 2004 with a minimum follow-up of 12 months. RESULTS:The study population compris...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00909.x
更新日期:2007-01-01 00:00:00
abstract::Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using t...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb03580.x
更新日期:1986-09-01 00:00:00
abstract::Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future. ...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2006.00809.x
更新日期:2006-10-01 00:00:00
abstract::Polypharmacy is a widely employed treatment strategy in epilepsy, particularly for individuals with poorly controlled seizures. Drug combinations should be carefully considered to minimize the potential for unfavorable interactions. Older-generation antiepileptic drugs (AEDs) are well known for their pharmacokinetic i...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2007.00983.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Studies have found that affected individuals who believe the cause of their disorder is genetic may react in various ways, including optimism for improved treatments and pessimism due to perceived permanence of the condition. This study assessed the psychosocial impact of genetic attribution among people with...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16352
更新日期:2019-11-01 00:00:00
abstract::Before a health education program can be established, one must first know what the target population believes and does with respect to the disease in question. Therefore, we performed a study among Tanzanian rural inhabitants to identify their knowledge, attitude, and practice (KAP) toward epilepsy: 3,256 heads of hou...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb02127.x
更新日期:1993-11-01 00:00:00
abstract::In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16596
更新日期:2020-08-01 00:00:00
abstract::Intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rCRF) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. Such an effect was still present in rats neonatally treated with saline but was absent in...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1990.tb05510.x
更新日期:1990-11-01 00:00:00
abstract::We examined the relationship between clinical characteristics and EEG classification in all children with febrile seizures examined at the University Pediatric Clinic, Skopje, Yugoslavia between 1982 and 1984. This is the only facility in Macedonia providing EEG or neurologic consultation for children. EEGs were class...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb02282.x
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.38601.x
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:Schizophrenia and epilepsy may share a mutual susceptibility. This study examined the bidirectional relation between the two disorders. METHODS:We used claims data obtained from the Taiwan National Health Insurance database to conduct retrospective cohort analyses. Analysis 1 compared 5,195 patients with incid...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03268.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS),...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13509
更新日期:2016-10-01 00:00:00