Effects of prenatal antiepileptic drug exposure on newborn brain activity.

abstract：PURPOSE:Decline in verbal memory as a surgical complication remains an unresolved problem in mesial temporal lobe epilepsy. Some areas in the temporal lobe associated with the language function, often including the basal temporal language area, have been removed or transected by conventional surgical procedures. The au...

journal_title：Epilepsia

authors： Mikuni N,Miyamoto S,Ikeda A,Satow T,Taki J,Takahashi J,Ohigashi Y,Hashimoto N

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:In patients with tuberous sclerosis complex (TSC), a wide range of neurologic abnormalities develop, including mental retardation and seizures. Brains from TSC patients are characterized by the presence of cortical tubers, large dysmorphic neurons, and abnormal cytomegalic cells. Although analysis of human TSC ...

journal_title：Epilepsia

authors： Takahashi DK,Dinday MT,Barbaro NM,Baraban SC

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Occipital lobe epilepsy (OLE) presents in childhood with different manifestations, age of onset and EEG features that form distinct syndromes. The ictal clinical symptoms are difficult to correlate with onset in particular areas in the occipital lobes, and the EEG recordings have not been able to overcome this ...

journal_title：Epilepsia

authors： Leal A,Dias A,Vieira JP,Secca M,Jordão C

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (GAERS), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala...

journal_title：Epilepsia

authors： Carçak N,Zheng T,Ali I,Abdullah A,French C,Powell KL,Jones NC,van Raay L,Rind G,Onat F,O'Brien TJ

更新日期：2014-05-01 00:00:00

abstract：:Circling seizures (CS) have been described in association with focal lesions as well as with generalized EEG discharges. We report 1 patient with juvenile myoclonic epilepsy (JME) who developed CS. There were no focal findings on clinical examination, EEG, or imaging studies. We propose that CS in this patient may rep...

journal_title：Epilepsia

authors： Lancman ME,Asconapé JJ,Golimstok A

更新日期：1994-03-01 00:00:00

abstract：:Electrical stimulation of the visual cortex evoked the cortical focal seizure restricted in the neighbor cortex of the stimulated area in gallamine-immobilized cats. The present experiment was performed to clarify the participation of anticonvulsants in the cortex itself. Phenytoin and carbamazepine depressed the foca...

journal_title：Epilepsia

authors： Ito T,Hori M,Yoshida K,Shimizu M

更新日期：1977-03-01 00:00:00

abstract：OBJECTIVE:Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether...

journal_title：Epilepsia

authors： Taraschenko O,Fox HS,Pittock SJ,Zekeridou A,Gafurova M,Eldridge E,Liu J,Dravid SM,Dingledine R

更新日期：2019-03-01 00:00:00

abstract：:The mechanism by which animals develop tolerance to the antiepileptic effects of the carbonic anhydrase (CA) inhibitor, acetazolamide, was explored using a quantitative immunocytochemical method. Cerebral cortex sections of DBA/2J mice susceptible to audiogenic seizures and of C57BL/6J nonsusceptible mice were stained...

journal_title：Epilepsia

authors： Banks DA,Anderson RE,Woodbury DM

更新日期：1986-09-01 00:00:00

abstract：:Fifty-six consecutive epileptic patients with partial seizures (30 temporal, 26 extratemporal) and facial asymmetry were studied. Facial asymmetry was compared with EEG, radiologic, and other clinical findings. Thirty patients had a lesional epilepsy whereas 26 were considered cryptogenic. In lesional epilepsies, 60% ...

journal_title：Epilepsia

authors： Tinuper P,Plazzi G,Provini F,Cerullo A,Leonardi M,Agati R,Righini A,Montagna P

更新日期：1992-11-01 00:00:00

abstract：:The duration of epilepsy was evaluated in over 460 previously untreated patients who attended newly established epilepsy clinics in a rural area of Malawi. The mean duration at first attendance was 6.5 years. It was found that as the duration of active epilepsy increased, the number of patients having epilepsy of a gi...

journal_title：Epilepsia

authors： Watts AE

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To identify the short-term outcome of patients who had seizures while watching an animated cartoon TV program, "Pocket Monster," on December 16, 1997. METHODS:One and three years after the incident, questionnaires were sent to physicians of each patient about seizure recurrence, EEGs, and medication. RESULTS:...

journal_title：Epilepsia

authors： Ishiguro Y,Takada H,Watanabe K,Okumura A,Aso K,Ishikawa T

更新日期：2004-04-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Brivaracetam (BRV), a selective and high-affinity synaptic vesicle protein 2A ligand, is in development as adjunctive treatment for partial-onset (focal) seizures (POS). This phase 3 study (N01358; NCT01261325) aimed to confirm the efficacy and safety/tolerability of BRV in adults (≥ 16-80 years) with POS. M...

journal_title：Epilepsia

authors： Klein P,Schiemann J,Sperling MR,Whitesides J,Liang W,Stalvey T,Brandt C,Kwan P

更新日期：2015-12-01 00:00:00

abstract：:Ideal antiepileptic drugs (AEDs) are designed to stop seizures with limited central nervous system (CNS) side effects. However, CNS-related treatment-emergent adverse events (TEAEs) often occur in patients receiving AEDs. Topiramate (TPM) is an AED proven to be safe and effective as adjunctive treatment for epilepsy p...

journal_title：Epilepsia

authors： Tatum WO 4th,French JA,Faught E,Morris GL 3rd,Liporace J,Kanner A,Goff SL,Winters L,Fix A,PADS Investigators. Post-marketing antiepileptic drug survey.

更新日期：2001-09-01 00:00:00

abstract：:The performance of a new enzyme multiplied immunoassay technique (EMIT) was compared with other current methods, namely gas-liquid chromatography and thin-layer chromatography, for the determination of phenytoin and phenobarbital in serum. Forty-three serum samples were sent as unknowns to the participating laboratori...

journal_title：Epilepsia

authors： Schmidt D,Goldberg V,Guelen PJ,Johannessen S,Kleijn E,Meijer JW,Meinardi H,Richens A,Schneider H,Stein-Lavie Y,Symann-Louette N

更新日期：1977-09-01 00:00:00

abstract：:The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They have been subdivided into the "young old," 65-74 years, "middle old" 75-84 years, and the "old old," 85 years or older. But further subdivisions are needed: person...

journal_title：Epilepsia

authors： Leppik IE

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...

journal_title：Epilepsia

authors： Hattori J,Ouchida M,Ono J,Miyake S,Maniwa S,Mimaki N,Ohtsuka Y,Ohmori I

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ). METHODS:The 120 Wistar male rats were allocated randomly into four groups; (A) controls, and lead-treatment groups (B, C, and D) that received lead acetate ...

journal_title：Epilepsia

authors： Arrieta O,Palencia G,García-Arenas G,Morales-Espinosa D,Hernández-Pedro N,Sotelo J

更新日期：2005-10-01 00:00:00

abstract：:Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

journal_title：Epilepsia

authors： Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

journal_title：Epilepsia

authors： Awad A,Sarkhoo F

更新日期：2008-04-01 00:00:00

abstract：:Two cases of discontinuous status epilepticus (SE) characterized by repetitive asymmetrical atonic episodes associated with diffuse but asymmetrical spike waves are reported. Both patients also had partial seizures and interictal rolandic discharges. Dynamic EEG topography was performed to investigate the location or ...

journal_title：Epilepsia

authors： Kanazawa O,Kawai I

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：:The relationship between dreams and epilepsy is illustrated by two patients whose awake epileptic seizures and recurrent dreams during night sleep had similar content. In both of our cases the EEG showed right anterior temporal spike discharge, suggesting a role for the temporal lobe in the association between dreams ...

journal_title：Epilepsia

authors： Reami DO,Silva DF,Albuquerque M,Campos CJ

更新日期：1991-01-01 00:00:00

abstract：:The effect od dipropylacetic acid (DPA; Depakine) on the bemegride-induced convulsive threshold was investigated in alert cats. Forty-five min after DPA 200 mg/kg, s.c., no significant effect was obtained; 5 min after the same dose iv., protection from bemegride-induced seizures was pronounced. DPA did not decrease fo...

journal_title：Epilepsia

authors： van Duijn H,Beckmann MK

更新日期：1975-03-01 00:00:00

abstract：PURPOSE:This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS:The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [...

journal_title：Epilepsia

authors： Skradski S,White HS

更新日期：2000-01-01 00:00:00

abstract：:Little is known about the effects of carbamazepine (CBZ) on sleep despite the relationship between sleep and epilepsy and the common clinical use of CBZ. As part of a larger study on sleep and interictal activity in kindled cats, we performed sleep recordings in 11 normal cats before and after acute administration of ...

journal_title：Epilepsia

authors： Gigli GL,Gotman J,Thomas ST

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:We evaluated the anticonvulsant efficacy of topiramate (TPM), a structurally novel antiepileptic drug (AED), in amygdala kindled rats that had been preselected with respect to their response to phenytoin (PHT). METHODS:Anticonvulsant response was tested by determining the afterdischarge threshold (ADT; i.e., a...

journal_title：Epilepsia

authors： Reissmüller E,Ebert U,Löscher W

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:We analyzed sequential changes in the localization of EEG foci along with age to identify a specific EEG pattern, and the relation between the clinical manifestations and the EEG pattern in patients with Panayiotopoulos syndrome (PS). METHODS:The subjects were 76 children, who had been followed up >2 years wit...

journal_title：Epilepsia

authors： Ohtsu M,Oguni H,Hayashi K,Funatsuka M,Imai K,Osawa M

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Epileptic seizures are associated with a dysregulation of electrical brain activity on many different spatial scales. To better understand the dynamics of epileptic seizures, that is, how the seizures initiate, propagate, and terminate, it is important to consider changes of electrical brain activity on differe...

journal_title：Epilepsia

authors： Schindler K,Gast H,Goodfellow M,Rummel C

更新日期：2012-09-01 00:00:00

abstract：:Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than sodium acetate; in each ...

journal_title：Epilepsia

authors： Colannino NM,Lipke H

更新日期：1983-10-01 00:00:00