Abstract:
:The effect od dipropylacetic acid (DPA; Depakine) on the bemegride-induced convulsive threshold was investigated in alert cats. Forty-five min after DPA 200 mg/kg, s.c., no significant effect was obtained; 5 min after the same dose iv., protection from bemegride-induced seizures was pronounced. DPA did not decrease focal discharges in sensorimotor cortex produced by topical cobalt, although spread of epileptogenic activity from the focus was inhibited. DPA antiepileptic protection tested by the same procedure was about the same as that given by phenobarbital and less than that given by diazepam.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
van Duijn H,Beckmann MKdoi
10.1111/j.1528-1157.1975.tb04724.xkeywords:
subject
Has Abstractpub_date
1975-03-01 00:00:00pages
83-90issue
1eissn
0013-9580issn
1528-1167journal_volume
16pub_type
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