Abstract:
:Surgery for seizures arising from the rolandic area can be performed effectively, and accurate mapping of eloquent regions may improve seizure and functional outcome. Noninvasive cortical mapping is, however, hardly feasible in young children. We studied two children with epileptogenic focal cortical dysplasia (FCD) type IIb in the rolandic area, in whom preoperative passive task functional MRI (fMRI) during sedation helped planning a tailored surgical approach. In one patient the dysplastic cortex was functionally activated. After complete lesionectomy both children exhibited motor impairment that readily improved. Repeat fMRI, performed after complete (Patient 1) or partial (Patient 2) recovery, demonstrated relocation of motor-related activations posterior to the area of resection. fMRI during sedation can be used to demonstrate postsurgical functional reorganization of the motor cortex in young children. There is interindividual variability in functional activation of FCD type IIb.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Barba C,Montanaro D,Frijia F,Giordano F,Blümcke I,Genitori L,De Masi F,Guerrini Rdoi
10.1111/j.1528-1167.2012.03524.xsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
e141-5issue
8eissn
0013-9580issn
1528-1167journal_volume
53pub_type
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