Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication.

abstract：:A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care....

journal_title：Epilepsia

authors： Rawlings GH,Reuber M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). METHODS:In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body w...

journal_title：Epilepsia

authors： Wang Y,Majors A,Najm I,Xue M,Comair Y,Modic M,Ng TC

更新日期：1996-10-01 00:00:00

abstract：:Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...

journal_title：Epilepsia

authors： Perucca E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To determine prevalence of active epilepsy in school children in a defined area and assess the usefulness of International League Against Epilepsy classification of seizures and epileptic syndromes, with special emphasis on frequency, additional handicaps, and therapeutic problems of severe cases. METHODS:The ...

journal_title：Epilepsia

authors： Waaler PE,Blom BH,Skeidsvoll H,Mykletun A

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are considered less favorable for open resection. METHODS:We retrospectively ...

journal_title：Epilepsia

authors： Gupta K,Cabaniss B,Kheder A,Gedela S,Koch P,Hewitt KC,Alwaki A,Rich C,Ramesha S,Hu R,Drane DL,Gross RE,Willie JT

更新日期：2020-08-01 00:00:00

abstract：:We conducted a retrospective parallel longitudinal cohort study comparing surgical and medical treatment for epilepsy. The surgical group contained 201 patients treated with resective surgery for epilepsy in Norway since the first operation in 1949 until January 1988. The 185 control group patients treated medically o...

journal_title：Epilepsia

authors： Guldvog B,Løyning Y,Hauglie-Hanssen E,Flood S,Bjørnaes H

更新日期：1991-05-01 00:00:00

abstract：:With microwave diathermy, febrile seizures were produced in epileptic chicks aged 2-5 days. Drugs that enhance GABAergic activity (i.e., GABA, muscimol, and progabide), as well as valproic acid and gamma-hydroxybutyric acid, produced dose-dependent increases in latency to onset of seizures. ...

journal_title：Epilepsia

authors： Pedder SC,Wilcox R,Tuchek J,Johnson DD,Crawford RD

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET. METH...

journal_title：Epilepsia

authors： Kilaru S,Bergqvist AGC

更新日期：2007-09-01 00:00:00

abstract：:Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who...

journal_title：Epilepsia

authors： Gillham RA

更新日期：1990-07-01 00:00:00

abstract：:Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain triglyceride ketogenic diet for the treatment of patients with drug-resistant epilepsy. Bec...

journal_title：Epilepsia

authors： Augustin K,Williams S,Cunningham M,Devlin AM,Friedrich M,Jayasekera A,Hussain MA,Holliman D,Mitchell P,Jenkins A,Chen PE,Walker MC,Williams RSB

更新日期：2018-11-01 00:00:00

abstract：:Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...

journal_title：Epilepsia

authors： Zhang CL,Gloveli T,Heinemann U

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To examine whether psychiatric comorbidity is a predictor of long-term seizure outcome following temporal lobe epilepsy surgery. METHODS:A sample of 434 adult patients who received temporal lobe resection to treat epilepsy between 1991 and 2009 and were psychiatrically assessed before surgery were followed f...

journal_title：Epilepsia

authors： Koch-Stoecker SC,Bien CG,Schulz R,May TW

更新日期：2017-06-01 00:00:00

abstract：:Twenty-seven patients with medically refractory paroxysmal disorders underwent EEG-video-audio (EVA) monitoring in an inpatient neurology-neurosurgery unit over 1-15 (mean 8.9) days. Fast visual review of all EEG records (5,784 h) and subsequent analysis of synchronized EVA patterns demonstrated a total of 208 partial...

journal_title：Epilepsia

authors： Pierelli F,Chatrian GE,Erdly WW,Swanson PD

更新日期：1989-09-01 00:00:00

abstract：:A 60-year-old patient had a 3-year history of recurrent memory disturbances. The video electroencephalographic (EEG) recording of one attack showed that the amnesic state, which clinically resembled transient global amnesia, was characterized by a normal EEG tracing followed by electroclinical complex partial seizures...

journal_title：Epilepsia

authors： Tassinari CA,Ciarmatori C,Alesi C,Cardinaletti L,Salvi F,Rubboli G,Plasmati R,Forti A,Michelucci R

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...

journal_title：Epilepsia

authors： Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical pictu...

journal_title：Epilepsia

authors： Schilling LP,Kieling RR,Pascoal TA,Kim HI,Lee MC,Kim YH,Paglioli E,Neto PR,Costa JC,Palmini A

更新日期：2013-08-01 00:00:00

abstract：:Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women ...

journal_title：Epilepsia

authors： Duncan S,Mercho S,Lopes-Cendes I,Seni MH,Benjamin A,Dubeau F,Andermann F,Andermann E

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Controversy persists about when EEG became a fundamental tool in the preoperative investigation for epilepsy surgery. We revisit Penfield's first use of invasive EEG monitoring, emphasizing its historical importance for the evolution of epilepsy surgery. METHODS:Patients' hospital charts and articles published...

journal_title：Epilepsia

authors： Almeida AN,Martinez V,Feindel W

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy. METHOD:Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) including women with specified nonepileptic...

journal_title：Epilepsia

authors： Bjørk MH,Veiby G,Reiter SC,Berle JØ,Daltveit AK,Spigset O,Engelsen BA,Gilhus NE

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Structural variations disrupting the gene encoding the neuron-specific splicing regulator RBFOX1 have been reported in three patients exhibiting epilepsy in comorbidity with other neuropsychiatric disorders. Consistently, the Rbfox1 knockout mouse model showed an increased susceptibility of seizures. The presen...

journal_title：Epilepsia

authors： Lal D,Trucks H,Møller RS,Hjalgrim H,Koeleman BP,de Kovel CG,Visscher F,Weber YG,Lerche H,Becker F,Schankin CJ,Neubauer BA,Surges R,Kunz WS,Zimprich F,Franke A,Illig T,Ried JS,Leu C,Nürnberg P,Sander T,EMINet Con

更新日期：2013-02-01 00:00:00

abstract：:The suppressive effect of sunglasses upon photoparoxysmal responses (PPRs) elicited by 15-Hz flicker stimuli with a low luminance of nearly 10 nits was studied in eight patients with photosensitive epilepsy. Using three commercially available sunglasses of neutral density (ND), blue, and brown, the influence upon gene...

journal_title：Epilepsia

authors： Takahashi T,Tsukahara Y

更新日期：1992-05-01 00:00:00

abstract：:Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP)...

journal_title：Epilepsia

authors： Mori N,Wada JA

更新日期：1989-05-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：:The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs dur...

journal_title：Epilepsia

authors： Mikkelsen B,Berggreen P,Joensen P,Kristensen O,Køhler O,Mikkelsen BO

更新日期：1981-08-01 00:00:00

abstract：:We evaluated language functions in 154 patients with left hemisphere speech dominance undergoing anterior temporal lobectomy (ATL). Measures of phonemic and semantic fluency, confrontation naming, repetition, comprehension, and reading were administered before and 3 weeks postoperatively. Patients were grouped by focu...

journal_title：Epilepsia

authors： Saykin AJ,Stafiniak P,Robinson LJ,Flannery KA,Gur RC,O'Connor MJ,Sperling MR

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ). METHODS:The 120 Wistar male rats were allocated randomly into four groups; (A) controls, and lead-treatment groups (B, C, and D) that received lead acetate ...

journal_title：Epilepsia

authors： Arrieta O,Palencia G,García-Arenas G,Morales-Espinosa D,Hernández-Pedro N,Sotelo J

更新日期：2005-10-01 00:00:00

abstract：:Our previous finding that intracerebroventricular (i.c.v.) administration of both thyrotropin-releasing hormone (TRH) and its analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate (DN-1417), suppressed seizure development of amygdaloid (AM) kindling and kindled AM seizures leads to a new hypoth...

journal_title：Epilepsia

authors： Kajita S,Ogawa N,Sato M

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...

journal_title：Epilepsia

authors： Pal DK,Das T,Sengupta S,Chaudhury G

更新日期：2002-08-01 00:00:00