Abstract:
:Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP) in a molar ratio of 1:3 (GLU 0.375 microM:ASP 1.125 microM). Strong bidirectional transhemispheric transfer between electrical and chemical kindling occurred at the secondary-site AM. In addition, at the primary-site retest, bidirectional posttransfer interference between electrical and chemical kindling was observed. These findings strongly suggest that endogenous GLU/ASP participates in the transsynaptic changes which are presumed to underlie the kindling phenomenon.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Mori N,Wada JAdoi
10.1111/j.1528-1157.1989.tb05298.xsubject
Has Abstractpub_date
1989-05-01 00:00:00pages
271-5issue
3eissn
0013-9580issn
1528-1167journal_volume
30pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract:PURPOSE:Magnetic resonance imaging (MRI) is an essential diagnostic tool for the management of epilepsy at modern epilepsy clinics. This study was conducted to incorporate MRI features into the international classification of epilepsies and epilepsy syndromes (ICEES) proposed by the International League Against Epileps...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.32901.x
更新日期:2002-05-01 00:00:00
abstract::We report identical twins with supernumerary ring chromosome 19 mosaicism, who had severe refractory epilepsy at an early age. The epilepsy was dominated largely by severe life-threatening tonic seizures. Both twins died, likely as a consequence of their severe epilepsy. They displayed no dysmorphic features. Eight ca...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.00304.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12697
更新日期:2014-09-01 00:00:00
abstract::Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01298.x
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To assess the long-term evolution of Unverricht-Lundborg disease (ULD), especially concerning myoclonus, seizures, and EEG characteristics. METHODS:We retrospectively evaluated 20 patients (six women, 14 men; mean age, 37.9 years; range, 26-53 years) with ULD who had been closely followed up since the onset of...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2006.00553.x
更新日期:2006-05-01 00:00:00
abstract::Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1996.tb01818.x
更新日期:1996-01-01 00:00:00
abstract::Advanced variant detection in genes underlying risk of sudden unexpected death in epilepsy (SUDEP) can uncover extensive epistatic complexity and improve diagnostic accuracy of epilepsy-related mortality. However, the sensitivity and clinical utility of diagnostic panels based solely on established cardiac arrhythmia ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12489
更新日期:2014-02-01 00:00:00
abstract::Electrical stimulation of the visual cortex evoked the cortical focal seizure restricted in the neighbor cortex of the stimulated area in gallamine-immobilized cats. The present experiment was performed to clarify the participation of anticonvulsants in the cortex itself. Phenytoin and carbamazepine depressed the foca...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1977.tb05588.x
更新日期:1977-03-01 00:00:00
abstract:PURPOSE:Posterior cortex epilepsies (PCEs) encompass a group of epilepsies originating from the occipital, parietal, or occipital border of the temporal lobe, or from any combination of these regions. When their seizures are refractory to pharmacologic treatment, these patients are usually referred for surgery. The aim...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2005.70904.x
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:The aim of this article is to review the literature on the effects of psychostimulants in epileptic subjects in order to reach a consensus statement regarding the use or abuse of these substances. METHODS:Psychostimulant substances have been considered the drugs that share the ability to produce excitation of ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.043s2028.x
更新日期:2002-01-01 00:00:00
abstract::In 1990, the NIH Consensus Conference Panel on epilepsy surgery called for the development and use of reliable and valid health-related quality-of-life (HRQOL) measures in epilepsy surgery studies. A HRQOL measure for epilepsy surgery patients has been developed and evaluated. The procedure, which could also be used t...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb05912.x
更新日期:1993-01-01 00:00:00
abstract::The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1987.tb03654.x
更新日期:1987-07-01 00:00:00
abstract::Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12061
更新日期:2013-04-01 00:00:00
abstract::Several different types of chemical compounds are useful as antiepileptic drugs. Their mechanisms of action, as well as their physical structures, differ. Compounds such as carbamazepine, phenytoin, and probably valproate act by modifying ionic conductances, particularly sodium and calcium, in excitable membranes, thu...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1987.tb05772.x
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Recent reports define temporal lobe epilepsy with amygdala enlargement (TLE-AE) as a distinct electroclinical syndrome comparable to TLE with hippocampal sclerosis. In this retrospective observational study, we present the largest consecutive series of patients with new-onset TLE-AE to date and describe clini...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13471
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To induce status epilepticus (SE) followed by the subsequent onset of spontaneous recurrent seizures, thus characterizing a new model of temporal lobe epilepsy in a nonhuman primate. METHODS:Male and female marmosets (Callithrix jacchus) (n = 18), ages between 2 and 8 years, were injected with domoic acid (0.5...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2005.01023.x
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To prospectively investigate the incidence of interictal psychoses of epilepsy patients, and make a comparison between those with interictal psychoses and patients with schizophrenia in respect to their responses to antipsychotic drugs, as well as psychotic states. METHODS:We undertook a two-part prospective i...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01230.x
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To analyze the relationship between ictal electroencephalography (EEG) and ictal single-photon emission computed tomography (SPECT) and to evaluate the diagnostic usefulness of ictal SPECT as an independent presurgical evaluation technique. METHODS:Sixty-eight patients with temporal lobe epilepsy who underwent...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00278.x
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:The objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow-up) pediatric epilepsy surgery. METHODS:The systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyse...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.14737
更新日期:2019-05-01 00:00:00
abstract::In a double-blind, randomized, parallel-group trial, we compared topiramate (TPM) with placebo as add-on therapy in patients with refractory partial epilepsy. TPM was titrated either to the target dosage of 800 mg/ day [400 mg twice daily (b.i.d)] or to the maximal tolerated dose if lower. Twenty-eight (28) patients w...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1528-1157.1996.tb00606.x
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNE...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.14619
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 +/- 1 days; the id...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.46904.x
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1997.tb01203.x
更新日期:1997-10-01 00:00:00
abstract::We present a technique for automatic detection of epileptic spikes in electroencephalogram (EEG) recordings. We used a nonlinear modeling method that enables us to detect rapidly and accurately epileptic behavior in the EEG signal. Our approach is illustrated by an application to interictal activity from a patient wit...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.43.s.5.7.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13703
更新日期:2017-04-01 00:00:00
abstract::The use of lamotrigine (LTG) can be limited by the occurrence of cutaneous adverse drug reactions (cADRs) that range from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced c...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13087
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS:We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. RESULTS:We analyzed retrospectiv...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16414
更新日期:2020-02-01 00:00:00
abstract::Neuropsychological evaluation differs from other methods used to localize cerebral lesions in that it analyzes cognitive function. Tests sample widely among cognitive abilities, contrasting language proficiency with visuospatial skills. A thorough assessment of memory is crucial in the investigation because of the pro...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Doublecortin (DCX) is a microtubule-associated protein with regulatory roles in radial and tangential migration of neurons during cortical development. In normal adult cortex there is restricted expression, and DCX is widely used as a marker of neurogenesis. Imperfect corticogenesis is thought to underpin many ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02194.x
更新日期:2009-12-01 00:00:00
abstract::Cinromide (BW-122U) was evaluated in an open pilot study of absence seizures in three naive (previously untreated for absence seizures) patients (one male and two females, 7 to 8 years of age). In these naive patients, cinromide was found to be well tolerated but ineffective in reducing generalized spike-and-wave disc...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1983.tb04911.x
更新日期:1983-08-01 00:00:00