Abstract:
PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RESULTS:The calculated relative risk (RR) value for AED polytherapy compared with monotherapy was below 1.0 in only 3 of 14 literature publications. In the register, at 1 year postnatally there were fetal malformations in 5.32% of 282 AED polytherapy pregnancies, and in 7.84% of 791 AED monotherapy pregnancies, an RR of 0.68 [95% confidence interval (CI) 0.39-1.17). For pregnancies exposed to valproate, the RR of fetal malformation (0.39, 95% CI 0.20-0.89) was lower in polytherapy (7.26%) than in monotherapy (17.9%); the difference did not depend on valproate dosage. The RR values for fetal malformation were not significantly different for AED polytherapy and monotherapy when valproate was not involved. Logistic regression suggested that coadministration of lamotrigine may have reduced the malformation risk from valproate. DISCUSSION:The fetal hazard of AED polytherapy relative to monotherapy may depend more on the degree of exposure to valproate than on the fact of polytherapy per se. Coadministration with lamotrigine may lower the fetal risk of valproate therapy.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJdoi
10.1111/j.1528-1167.2009.02336.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
805-10issue
5eissn
0013-9580issn
1528-1167pii
EPI2336journal_volume
51pub_type
杂志文章,评审相关文献
EPILEPSIA文献大全abstract:PURPOSE:Bone disease and fractures are common with chronic antiepileptic drug (AED) therapy, but the underlying mechanisms are poorly understood. This study aimed to characterize adverse bone effects of valproate and to identify mouse strains either resistant or sensitive to these effects. METHODS:Seven mouse strains ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02516.x
更新日期:2010-06-01 00:00:00
abstract::Cortical dysplasia (CD, also known as malformations of cortical development) are the pathological substrates in a large percentage of patients with pharmacoresistant epilepsy who may be amenable to surgical treatment. Therefore, research on the mechanisms of dysplastic lesion formation and epileptogenicity is of param...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2007.01064.x
更新日期:2007-01-01 00:00:00
abstract::Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02218.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16487
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:This study investigated the impact of a treatment information package on patients being monitored for possible surgical treatment for temporal lobe epilepsy. METHODS:One hundred patients were randomly assigned to either a high- or low-information preparation condition. Levels of anxiety were tested soon after ...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1528-1157.1999.tb02037.x
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS:In total, 34 subjects with unilateral left (n = 15) or right (n = 19)...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.27004.x
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Previous studies have estimated medical care costs of epilepsy by applying unit costs to estimated utilization or by summing costs for (a) ambulatory care and hospitalizations coded as epilepsy and (b) procedures and drugs specifically associated with the diagnosis or treatment of epilepsy. These methods may un...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00288.x
更新日期:2000-08-01 00:00:00
abstract::We report 10 seizure-related thermal injuries severe enough to require hospitalization in patients with epilepsy. Eight of the ten incidents were with patients who had had seizures with impaired consciousness two or more times a month. This suggests that seizure frequency is a risk factor and implies the importance of...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb02290.x
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would del...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb02068.x
更新日期:1999-02-01 00:00:00
abstract:PURPOSE: Vagus nerve stimulation (VNS) provides partial relief of medically refractory partial seizures in a subset of patients. The optimal pattern of stimulation and the mechanism of the antiseizure effects are uncertain. Establishing the efficacy of VNS in an animal model of epilepsy would provide an experimental p...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2012.03646.x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:We evaluated the anticonvulsant efficacy of topiramate (TPM), a structurally novel antiepileptic drug (AED), in amygdala kindled rats that had been preselected with respect to their response to phenytoin (PHT). METHODS:Anticonvulsant response was tested by determining the afterdischarge threshold (ADT; i.e., a...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00176.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16646
更新日期:2020-10-01 00:00:00
abstract::The incidence of epilepsy and of all unprovoked seizures was determined for residents of Rochester, Minnesota U.S.A. from 1935 through 1984. Age-adjusted incidence of epilepsy was 44 per 100,000 person-years. Incidence in males was significantly higher than in females and was high in the first year of life but highest...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb02586.x
更新日期:1993-05-01 00:00:00
abstract::Spontaneously epileptic rats (SER) are a double mutant (zi/zi, tm/tm) spontaneously exhibiting both tonic and absence-like seizures. We examined the long-term effects of continual intake of phenobarbital (PB) on SER as a method of assessing long-term evaluation of antiepileptic drugs (AEDs). Food pellets containing 0....
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1990.tb05353.x
更新日期:1990-01-01 00:00:00
abstract::Brain slices incubated with glucose have provided most of our knowledge on cellular, synaptic, and network driven mechanisms. It has been recently suggested that γ-aminobutyric acid (GABA) excites neonatal neurons in conventional glucose-perfused slices but not when ketone bodies metabolites, pyruvate, and/or lactate ...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2011.03132.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are considered less favorable for open resection. METHODS:We retrospectively ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16614
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Patients with gliomas frequently present with seizures, but the factors associated with seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested the contribution of aberrant glutamate release from gliomas on glioma-asso...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2012.03557.x
更新日期:2012-08-01 00:00:00
abstract:AIM:To trace the concept that the cerebral cortex is the site of epileptogenesis before Hughlings Jackson published the idea in 1870 in the paper "A study of convulsions" which marks the beginning of modern epileptology. METHOD:Perusal of 19th century English language medical literature. RESULT:The existence of corti...
journal_title:Epilepsia
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1528-1167.2007.01163.x
更新日期:2007-11-01 00:00:00
abstract::A 60-year-old patient had a 3-year history of recurrent memory disturbances. The video electroencephalographic (EEG) recording of one attack showed that the amnesic state, which clinically resembled transient global amnesia, was characterized by a normal EEG tracing followed by electroclinical complex partial seizures...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb05545.x
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb00749.x
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb01986.x
更新日期:1999-01-01 00:00:00
abstract::Fifteen children (7 boys and 8 girls) with generalized tonic-clonic seizures (GTCS) and partial seizures with elementary or complex symptomatology, treated with carbamazepine (CBZ) alone (n = 7) or in combination with either phenobarbital (PB, n = 6) or clobazam (CLB, n = 2) given for at least 3 months at stable indiv...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1528-1157.1993.tb02390.x
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Mesial temporal sclerosis (MTS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures. METHODS:We searched evidence for apoptotic cell death in temporal l...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2003.37402.x
更新日期:2003-06-01 00:00:00
abstract::Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1976.tb03409.x
更新日期:1976-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequent...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00904.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13486
更新日期:2016-10-01 00:00:00
abstract::Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/epi.13791
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To describe the semiological features of auditory aura and to assess their possible lateralizing value in partial epilepsy. METHODS:Out of a series of 8,000 patients with epilepsy, we investigated 121 cases with partial seizures in whom auditory features were the first ictal symptom. According to the dominant ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00881.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.13256
更新日期:2016-01-01 00:00:00
abstract::In 2011, the American Academy of Neurology (AAN) established eight epilepsy quality measures (EQMs) for chronic epilepsy treatment to address deficits in quality of care. This study assesses the relationship between adherence to these EQMs and epilepsy-related adverse hospitalizations (ERAHs). A retrospective chart re...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12965
更新日期:2015-05-01 00:00:00