Adverse effects of valproate on bone: defining a model to investigate the pathophysiology.

abstract：OBJECTIVE:Guidelines recommend that encephalopathic critically ill children undergo continuous electroencephalographic (CEEG) monitoring for electrographic seizure (ES) identification and management. However, limited data exist on antiseizure medication (ASM) safety for ES treatment in critically ill children. METHODS...

journal_title：Epilepsia

authors： Fung FW,Jacobwitz M,Vala L,Parikh D,Donnelly M,Xiao R,Topjian AA,Abend NS

更新日期：2019-10-01 00:00:00

abstract：:Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...

journal_title：Epilepsia

authors： Jones JE,Bell B,Fine J,Rutecki P,Seidenberg M,Hermann B

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:We studied cerebral perfusion patterns in the various subtypes of TLE, as determined by pathology and good outcome after temporal lobectomy (as confirmation of temporal origin). METHODS:We studied clinical features and ictal technetium 99m hexamethyl-propyleneamineoxime (99mTc-HM-PAO) single-photon emission-co...

journal_title：Epilepsia

authors： Ho SS,Berkovic SF,McKay WJ,Kalnins RM,Bladin PF

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Inhibition of microRNA-134 by an oligonucleotide antagomir (ant-134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess what potential adverse effects it may have on naive brain tissue...

journal_title：Epilepsia

authors： Morris G,Brennan GP,Reschke CR,Henshall DC,Schorge S

更新日期：2018-08-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:In the presurgical evaluation of children and juvenile patients with refractory focal epilepsy, the main challenge is to localize the point of seizure onset as precisely as possible. We compared results of the conventional electroencephalography-functional magnetic resonance imaging (EEG-fMRI) analysis with tho...

journal_title：Epilepsia

authors： Elshoff L,Groening K,Grouiller F,Wiegand G,Wolff S,Michel C,Stephani U,Siniatchkin M

更新日期：2012-09-01 00:00:00

abstract：:The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here refer...

journal_title：Epilepsia

authors： Bernard C

更新日期：2020-10-16 00:00:00

abstract：PURPOSE:There is controversy between clinicians and statisticians on the appropriateness of the number needed to treat (NNT) as a summary statistic to report the effectiveness of a treatment. We examine the two viewpoints and make proposals concerning the reporting of clinical trial results. METHODS:In the context of ...

journal_title：Epilepsia

authors： Lesaffre E,Boon P,Pledger GW

更新日期：2000-04-01 00:00:00

abstract：:Nocturnal frontal lobe epilepsy (NFLE) is a condition primarily characterized by seizures occurring exclusively or predominantly during sleep, the semiology of which suggest a frontal lobe origin and, more specifically, the involvement of the orbitofrontal or mesial frontal regions. It is usually considered as a relat...

journal_title：Epilepsia

authors： Ryvlin P,Rheims S,Risse G

更新日期：2006-01-01 00:00:00

abstract：:Our study investigated public attitudes toward epilepsy, and knowledge and understanding of epilepsy in Hungary. We compared changes of public attitudes in the last six years, hypothesizing a trend of positive changes because of recent national initiatives for acceptance and integration of people with epilepsy (e.g., ...

journal_title：Epilepsia

authors： Mirnics Z,Czikora G,Závecz T,Halász P

更新日期：2001-01-01 00:00:00

abstract：:We report 10 seizure-related thermal injuries severe enough to require hospitalization in patients with epilepsy. Eight of the ten incidents were with patients who had had seizures with impaired consciousness two or more times a month. This suggests that seizure frequency is a risk factor and implies the importance of...

journal_title：Epilepsia

authors： Spitz MC

更新日期：1992-01-01 00:00:00

abstract：:Previous studies have demonstrated that bicuculline-induced seizures of 1-2 h in duration lead to structural, metabolic, and circulatory alterations in the rat brain. Such alterations were observed even though cerebral oxygenation seemed adequate. In the present study, we explored whether pentylenetetrazole, a convuls...

journal_title：Epilepsia

authors： Ingvar M,Söderfeldt B,Folbergrová J,Kalimo H,Olsson Y,Siesjö BK

更新日期：1984-04-01 00:00:00

abstract：:We report a surgically treated case of early infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia. Tonic-clonic seizures followed by a series of spasms occurred about a hundred times a day at a few days of age. Interictal electroencephalogram (EEG) revealed a suppr...

journal_title：Epilepsia

authors： Komaki H,Sugai K,Sasaki M,Hashimoto T,Arai N,Takada E,Maehara T,Shimizu H

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges (SWD) on the E...

journal_title：Epilepsia

authors： Dedeurwaerdere S,Vonck K,Van Hese P,Wadman W,Boon P

更新日期：2005-01-01 00:00:00

abstract：:Mutations in a number of genes encoding voltage-gated sodium channels cause a variety of epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, severe myoclonic epilepsy of infancy). Most of these mutations are in the SCN1A gene, and all are d...

journal_title：Epilepsia

authors： Escayg A,Goldin AL

更新日期：2010-09-01 00:00:00

abstract：:Two patients developed clinical and laboratory evidence of systemic lupus erythematosus (SLE) during treatment with valproate (VPA) preparations. The first patient, a 47-year-old man, had fever, malaise, and thrombocytopenia 1 month after VPA was added to phenytoin (PHT) and primidone (PRM). He developed high titers o...

journal_title：Epilepsia

authors： Bleck TP,Smith MC

更新日期：1990-05-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：:The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact o...

journal_title：Epilepsia

authors： Galanopoulou AS,Kokaia M,Loeb JA,Nehlig A,Pitkänen A,Rogawski MA,Staley KJ,Whittemore VH,Dudek FE

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effe...

journal_title：Epilepsia

authors： Kahriman M,Minecan D,Kutluay E,Selwa L,Beydoun A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To determine whether acute exacerbations of cirrhotic liver disease are associated with higher odds of readmission for epilepsy or status epilepticus. METHODS:The New York State Inpatient Database is a statewide dataset containing data on 97% of hospitalizations for New York State. In this retrospective, cas...

journal_title：Epilepsia

authors： Gursky JM,Rossi KC,Jetté N,Dhamoon MS

更新日期：2020-03-01 00:00:00

abstract：:Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of v...

journal_title：Epilepsia

authors： Meldrum BS

更新日期：1997-01-01 00:00:00

abstract：:The management of epilepsy is an essential clinical issue in many patients with brain tumors. Tumoral epilepsy is often drug resistant and is associated with poor quality of life. Surgery represents a key therapeutic option in the management of patients with refractory tumoral epilepsy, with high rates of postoperativ...

journal_title：Epilepsia

authors： Rheims S,Ducray F,Ryvlin P

更新日期：2013-12-01 00:00:00

abstract：:Genetic factors play a major role in the etiology of juvenile myoclonic epilepsy (JME), a common form of idiopathic generalized epilepsy, but so far, genes related to JME remain largely unknown. JME shares electroclinical features with Unverricht-Lundborg disease (progressive myoclonic epilepsy type 1; EPM1), a form o...

journal_title：Epilepsia

authors： Mumoli L,Tarantino P,Michelucci R,Bianchi A,Labate A,Franceschetti S,Marini C,Striano P,Gagliardi M,Ferlazzo E,Sofia V,Pennese L,Annesi G,Aguglia U,Guerrini R,Zara F,Gambardella A,Genetic Commission, Italian League Agai

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To estimate magnetoencephalography (MEG) correlates of different types of aura in temporal lobe epilepsy (TLE). METHODS:MEG study was performed on 57 patients (26 male and 31 female) with TLE, whose ages ranged from 14-46 years (mean 27 years). Interictal magnetoencephalograms showing discharges were analyzed,...

journal_title：Epilepsia

authors： Fukao K,Inoue Y,Yagi K

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...

journal_title：Epilepsia

authors： Zarnowska I,Luszczki JJ,Zarnowski T,Buszewicz G,Madro R,Czuczwar SJ,Gasior M

更新日期：2009-05-01 00:00:00

abstract：:Several different types of chemical compounds are useful as antiepileptic drugs. Their mechanisms of action, as well as their physical structures, differ. Compounds such as carbamazepine, phenytoin, and probably valproate act by modifying ionic conductances, particularly sodium and calcium, in excitable membranes, thu...

journal_title：Epilepsia

authors： Ferrendelli JA

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Major depression is a common psychiatric comorbidity in chronic epilepsy that is frequently unrecognized and untreated. A variety of self-report mood inventories are available, but their validity as well as ability to detect major depression in epilepsy remains uncertain. The purpose of this study was to determ...

journal_title：Epilepsia

authors： Jones JE,Hermann BP,Woodard JL,Barry JJ,Gilliam F,Kanner AM,Meador KJ

更新日期：2005-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans....

journal_title：Epilepsia

authors： Christensen J

更新日期：2012-09-01 00:00:00