Is the cell death in mesial temporal sclerosis apoptotic?

abstract：:The clinical identification of neonatal seizures is critical for the recognition of brain dysfunction; however, diagnosis is often difficult because of the poorly organized and varied nature of these behaviors. Current classification systems are limited in their ability to communicate motor, autonomic, and electroence...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To study the neurophysiologic characteristics of epileptic myoclonus in patients with Lennox-Gastaut syndrome (LGS) and myoclonic astatic epilepsy (MAE). METHODS:Three patients with symptomatic LGS (mean age, 15 years +/- 4) and three with cryptogenic MAE (mean age, 9 years +/- 3) were studied. Temporal relati...

journal_title：Epilepsia

authors： Bonanni P,Parmeggiani L,Guerrini R

更新日期：2002-06-01 00:00:00

abstract：:Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of v...

journal_title：Epilepsia

authors： Meldrum BS

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...

journal_title：Epilepsia

authors： Simone IL,Federico F,Tortorella C,De Blasi R,Bellomo R,Lucivero V,Carrara D,Bellacosa A,Livrea P,Carella A

更新日期：1999-07-01 00:00:00

abstract：:Cortical dysplasia (CD, also known as malformations of cortical development) are the pathological substrates in a large percentage of patients with pharmacoresistant epilepsy who may be amenable to surgical treatment. Therefore, research on the mechanisms of dysplastic lesion formation and epileptogenicity is of param...

journal_title：Epilepsia

authors： Najm IM,Tilelli CQ,Oghlakian R

更新日期：2007-01-01 00:00:00

abstract：:We report a surgically treated case of early infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia. Tonic-clonic seizures followed by a series of spasms occurred about a hundred times a day at a few days of age. Interictal electroencephalogram (EEG) revealed a suppr...

journal_title：Epilepsia

authors： Komaki H,Sugai K,Sasaki M,Hashimoto T,Arai N,Takada E,Maehara T,Shimizu H

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:We used a model of self-staining status epilepticus (SSSE), induced by brief intermittent stimulation of the perforant path in unanesthetized rats, to study the mechanism of initiation and of maintenance of SSSE and the role of neuropeptides in those processes. METHODS:The perforant path was stimulated intermi...

journal_title：Epilepsia

authors： Wasterlain CG,Mazarati AM,Naylor D,Niquet J,Liu H,Suchomelova L,Baldwin R,Katsumori H,Shirasaka Y,Shin D,Sankar R

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To investigate possible predictive factors for seizure control in a group of children and adults with low IQs (IQ, < or =70) who underwent resective surgery for intractable focal epilepsy and to study outcome with respect to seizures and neuropsychological functioning. We also studied psychosocial outcome in th...

journal_title：Epilepsia

authors： Bjørnaes H,Stabell KE,Heminghyt E,Røste GK,Bakke SJ

更新日期：2004-02-01 00:00:00

abstract：:The Epilepsy Association of Maryland, an affiliate of the Epilepsy Foundation of America (EFA), recognized that the Maryland state regulations and laws on driving licensing restricted the rights of individuals with epilepsy. After identifying the problem, the Association determined the needed changes and planned a leg...

journal_title：Epilepsia

authors： Kingham LA

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:Higher homocysteine levels were found in actively drinking patients with alcohol dependence. Recent studies have shown that high homocysteine levels are associated with alcohol-withdrawal seizures. The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in ac...

journal_title：Epilepsia

authors： Bleich S,Bayerlein K,Hillemacher T,Degner D,Kornhuber J,Frieling H

更新日期：2006-05-01 00:00:00

abstract：:Nuclear magnetic resonance is a noninvasive technique of imaging the brain using signals produced by magnetic fields and radiowaves. Sixteen patients with refractory temporal lobe epilepsy (TLE) had magnetic resonance imaging (MRI) during investigation for possible surgical management. These images plus those of 10 no...

journal_title：Epilepsia

authors： McLachlan RS,Nicholson RL,Black S,Carr T,Blume WT

更新日期：1985-11-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 +/- 1 days; the id...

journal_title：Epilepsia

authors： Junker H,Späte K,Suofu Y,Walther R,Schwarz G,Kammer W,Nordheim A,Walker LC,Runge U,Kessler C,Popa-Wagner A

更新日期：2005-03-01 00:00:00

abstract：:The Asia-Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and O...

journal_title：Epilepsia

authors： Kwan P,Cabral-Lim L,D'Souza W,Jain S,Lee BI,Liao W,Lim SH,Otsuki T,Tan CT,Wantanabe M,CAOA Research Task Force.

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathologic finding in intractable temporal lobe epilepsy (TLE). In many patients, HS is accompanied by an extrahippocampal lesion (EHL). We sought to assess the lobar distribution and side of EHLs in relation to HS in a large consecutive series of patients presentin...

journal_title：Epilepsia

authors： Hofman PA,Fitt G,Mitchell LA,Jackson GD

更新日期：2011-04-01 00:00:00

abstract：:The combination of phenobarbital (PB) and phenytoin (PHT) was recommended for many years for treatment of epilepsy in humans. We tested the effectiveness of the combination in a model of hippocampal seizures termed maximal dentate activation (MDA). Two parameters of MDA were measured: duration and time to onset. Neith...

journal_title：Epilepsia

authors： Stringer JL,Higgins MG

更新日期：1994-01-01 00:00:00

abstract：:Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than sodium acetate; in each ...

journal_title：Epilepsia

authors： Colannino NM,Lipke H

更新日期：1983-10-01 00:00:00

abstract：:A prospective study of the children in 12 families examined the impact of and adjustments to epilepsy in one of the parents. Young children allowed to see the parent's seizures and the treatment for those seizures adapted to the threat of illness in a parent by becoming involved in the care and supervision of the affe...

journal_title：Epilepsia

authors： Lechtenberg R,Akner L

更新日期：1984-02-01 00:00:00

abstract：AIM:To trace the concept that the cerebral cortex is the site of epileptogenesis before Hughlings Jackson published the idea in 1870 in the paper "A study of convulsions" which marks the beginning of modern epileptology. METHOD:Perusal of 19th century English language medical literature. RESULT:The existence of corti...

journal_title：Epilepsia

authors： Eadie MJ

更新日期：2007-11-01 00:00:00

abstract：:We explored Kentuckians' attitudes toward children with epilepsy. Questions compared respondents' attitudes about children with epilepsy, asthma, hyperactivity, and AIDS. Random digit dialing led to 617 completed interviews. The key questions asked concerned (a) how a pupil with each illness would alter the classroom ...

journal_title：Epilepsia

authors： Baumann RJ,Wilson JF,Wiese HJ

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:The Parry-Romberg syndrome is an unusual disorder frequently associated with epilepsy. The origin of this disease, and the cause of epilepsy, are unknown. This study is the first reported case of the Parry-Romberg syndrome, with intractable temporal lobe epilepsy, in which detailed microanatomic analyses have b...

journal_title：Epilepsia

authors： DeFelipe J,Segura T,Arellano JI,Merchán A,DeFelipe-Oroquieta J,Martín P,Maestú F,Ramón y Cajal S,Sánchez A,Sola RG

更新日期：2001-09-01 00:00:00

abstract：:Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life-threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. O...

journal_title：Epilepsia

authors： Iriarte J,Urrestarazu E,Alegre M,Macías A,Gómez A,Amaro P,Artieda J,Viteri C

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Validity studies on health-related quality of life (HRQOL) scales for pediatric epilepsy are few, and cross-validation with other samples has not been reported. This study was designed to assess the validity of three parent-rated measures of HRQOL in pediatric epilepsy: (a) the Impact of Childhood Illness Scale...

journal_title：Epilepsia

authors： Sherman EM,Slick DJ,Connolly MB,Steinbok P,Camfield C,Eyrl KL,Massey C,Farrell K

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:Uncontrolled epilepsy remains a significant health concern and requires new approaches to therapy. N-methyl-d-aspartate (NMDA) receptor blockade has been considered, but the adverse cognitive and behavioral effects of conventional NMDA-receptor antagonists have prevented the development of clinically useful com...

journal_title：Epilepsia

authors： Zhang DX,Williamson JM,Wu HQ,Schwarcz R,Bertram EH

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...

journal_title：Epilepsia

authors： Mitsuya K,Nitta N,Suzuki F

更新日期：2009-08-01 00:00:00

abstract：:This study evaluated the effects of depression and anxiety disorder symptoms on the health-related quality of life (HRQOL) of children and adolescents with epilepsy. Sixty children and adolescents and their parents participated in the study. Symptoms of anxiety disorders were identified by the Screen for Child Anxiety...

journal_title：Epilepsia

authors： Stevanovic D,Jancic J,Lakic A

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Appropriate treatment of generalized convulsive refractory status epilepticus (RSE) requires general anesthesia in the intensive care unit (ICU) with continuous electroencephalography (cEEG) monitoring. During out of office hours and weekends, cEEG monitoring is not always available. The Bispectral Index (BIS) ...

journal_title：Epilepsia

authors： Musialowicz T,Mervaala E,Kälviäinen R,Uusaro A,Ruokonen E,Parviainen I

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The Atkins diet may induce ketosis as does the ketogenic diet, without restrictions on calories, fluids, protein, or need for an inpatient fast and admission. Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy. METHODS:Twenty children were t...

journal_title：Epilepsia

authors： Kossoff EH,McGrogan JR,Bluml RM,Pillas DJ,Rubenstein JE,Vining EP

更新日期：2006-02-01 00:00:00

abstract：:We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given...

journal_title：Epilepsia

authors： Sawaishi Y,Yano T,Enoki M,Takada G

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to systematically review the literature on the interictal language profile in adult patients with epilepsy. METHODS:An extensive literature search was performed using MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, PASCAL, and PSYNDEXplus databases. Ke...

journal_title：Epilepsia

authors： Bartha-Doering L,Trinka E

更新日期：2014-10-01 00:00:00