The interictal language profile in adult epilepsy.

abstract：:Neurotrophic factors are involved in the survival of neurons as well as in the proliferation and differentiation of neuronal precursors. Therefore, modulating their levels in lesion areas may exert favorable effects on seizure-induced damage. However, it is unclear if damage limitation or repair may prevent epileptoge...

journal_title：Epilepsia

authors： Simonato M,Zucchini S

更新日期：2010-07-01 00:00:00

abstract：:Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

journal_title：Epilepsia

authors： Yasiry Z,Shorvon SD

更新日期：2012-12-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00

abstract：PURPOSE:To evaluate the antiepileptic and neuroprotective properties of topiramate (TPM) alone and with coadministration of the N-methyl-D-aspartate (NMDA)-receptor antagonist budipine in a rat model of refractory status epilepticus. METHODS:Male Sprague-Dawley rats had electrodes implanted into the perforant path and...

journal_title：Epilepsia

authors： Fisher A,Wang X,Cock HR,Thom M,Patsalos PN,Walker MC

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequent...

journal_title：Epilepsia

authors： Cormack F,Cross JH,Isaacs E,Harkness W,Wright I,Vargha-Khadem F,Baldeweg T

更新日期：2007-01-01 00:00:00

abstract：:Scrub typhus is an emerging infection, and there is little information about status epilepticus (SE) in scrub typhus. We report the clinical spectrum and outcome of SE in scrub typhus. In a 3-year prospective hospital-based observational study, all scrub typhus patients with SE were included. Scrub typhus was diagnose...

journal_title：Epilepsia

authors： Kalita J,Mani VE,Bhoi SK,Misra UK

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...

journal_title：Epilepsia

authors： Leary LD,Wang D,Nordli DR Jr,Engelstad K,De Vivo DC

更新日期：2003-05-01 00:00:00

abstract：:The objectives of this study were to investigate the lifetime prevalence of epileptic seizures in a population with acute intermittent porphyria (AIP) and to characterize the seizures and the seizure-triggering factors. A letter was sent to all patients with known AIP in Sweden registered at the National Porphyria Cen...

journal_title：Epilepsia

authors： Bylesjö I,Forsgren L,Lithner F,Boman K

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:Clobazam (CLB) has an important antiepileptic effect and is less expensive than the new antiepileptic drugs (AEDs), but still has not been considered as first-line drug in the treatment of epilepsy. We evaluated the efficacy of CLB as add-on therapy in patients with refractory partial epilepsy. METHODS:This wa...

journal_title：Epilepsia

authors： Montenegro MA,Cendes F,Noronha AL,Mory SB,Carvalho MI,Marques LH,Guerreiro CA

更新日期：2001-04-01 00:00:00

abstract：:Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (...

journal_title：Epilepsia

authors： Porter BE

更新日期：2008-06-01 00:00:00

abstract：:Sleep and epilepsy are interrelated. Understanding the relationship between epilepsy and sleep is important for optimizing management of the epilepsy patient in several ways. First, sleep modulates the expression of epileptic seizures and interictal epileptiform discharges. Second, epilepsy and its treatment influence...

journal_title：Epilepsia

authors： Malow BA

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Appropriate treatment of generalized convulsive refractory status epilepticus (RSE) requires general anesthesia in the intensive care unit (ICU) with continuous electroencephalography (cEEG) monitoring. During out of office hours and weekends, cEEG monitoring is not always available. The Bispectral Index (BIS) ...

journal_title：Epilepsia

authors： Musialowicz T,Mervaala E,Kälviäinen R,Uusaro A,Ruokonen E,Parviainen I

更新日期：2010-08-01 00:00:00

abstract：:Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immun...

journal_title：Epilepsia

authors： Pacifici R,Paris L,Di Carlo S,Pichini S,Zuccaro P

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Temporal lobe epilepsy is associated with the inflammatory process related to the basic mechanisms that lead to seizure susceptibility and brain damage. Platelet-activating factor (PAF), a potent, short-lived phospholipid mediator of inflammation, participates in physiologic signaling in the brain. However, aft...

journal_title：Epilepsia

authors： Musto AE,Samii M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...

journal_title：Epilepsia

authors： Drane DL,Loring DW,Voets NL,Price M,Ojemann JG,Willie JT,Saindane AM,Phatak V,Ivanisevic M,Millis S,Helmers SL,Miller JW,Meador KJ,Gross RE

更新日期：2015-01-01 00:00:00

abstract：:Sudden unexplained death syndrome (SUDS) accounts for about 10% of deaths in patients with epilepsy. It is associated with subtherapeutic postmortem serum antiepileptic drug (AED) levels but no anatomic cause of death on autopsy. The mechanisms of death are not known. We investigated 44 cases of SUDS for details of se...

journal_title：Epilepsia

authors： Earnest MP,Thomas GE,Eden RA,Hossack KF

更新日期：1992-03-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) can be used for noninvasive measurement of more than two dozen small metabolites in the brains of living animals and humans. In the first decade of its use for study of seizure phenomena in animals, MRS successfully detected in vivo seizure-induced cerebral acidosis and reduction ...

journal_title：Epilepsia

authors： Prichard JW

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS:The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [...

journal_title：Epilepsia

authors： Skradski S,White HS

更新日期：2000-01-01 00:00:00

abstract：:In developed countries, the incidence of epilepsy is 50-100 cases per 100,000 population per year and the prevalence is approximately 5 to 8 cases per 1,000 population. Epilepsy is by far the most prevalent serious neurologic condition. Mortality rates in epilepsy are two to four times those found in matched nonepilep...

journal_title：Epilepsia

authors： Shorvon SD

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To evaluate the significance of lateralization of ictal upper limb automatisms in patients with temporal lobe epilepsy (TLE). METHODS:Ictal upper limb automatisms of 28 patients with temporal lobe epilepsy were quantified. Duration of automatisms in relation to total seizure duration, movement speed, extent, l...

journal_title：Epilepsia

authors： Mirzadjanova Z,Peters AS,Rémi J,Bilgin C,Silva Cunha JP,Noachtar S

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Diazepam buccal film (DBF) is in development for treatment of patients experiencing bouts of increased seizure activity. We assessed safety, tolerability, and usability of self- or caregiver-administered DBF in the outpatient setting. METHODS:Patients aged 2-65 years needing treatment with a rescue benzodiaz...

journal_title：Epilepsia

authors： Seinfeld S,Gelfand MA,Heller AH,Buan C,Slatko G

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Chronic cellular inflammation closely associated with epilepsy without an active infection is a hallmark of Rasmussen encephalitis (RE). RE has typical and defining features lacking in other rare epilepsy patients who also have neocortical lymphocytes without an identifiable cause. A patient with malformations ...

journal_title：Epilepsia

authors： Rhodes RH,Lehman RM,Wu BY,Roychowdhury S

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:In the last decade several studies have been published on incidence, etiology, and prognosis of status epilepticus (SE) with population-based data from the United States and Europe. The aim of this review is to summarize the available information on the epidemiology of SE and to outline the sources of the var...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC,Cascino G,Hauser WA,Coeytaux A,Galobardes B,Morabia A,Jallon P

更新日期：2005-01-01 00:00:00

abstract：:Ketogenic diets (KDs) are effective treatments for epilepsy. The mechanisms of action are poorly understood. In some experimental seizure models, calorie restriction and hypoglycemia may augment the antiseizure effects of KDs. In addition, inhibiting glycolysis or diverting glucose from the glycolytic pathway inhibits...

journal_title：Epilepsia

authors： Yamada KA

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Unresolved past stressful events can induce a state of vulnerability to epilepsy and comorbidities. Using an experimental model of stress-induced vulnerability to depression, we tested whether an antioxidant treatment applied after the onset of epileptogenesis was disease modifying and could prevent the occur...

journal_title：Epilepsia

authors： Becker C,Mancic A,Ghestem A,Poillerat V,Claverie D,Bartolomei F,Brouillard F,Benoliel JJ,Bernard C

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:To investigate the neurochemical pattern in patients with benign adult familial myoclonic epilepsy (BAFME/FAME), an inherited form of myoclonic epilepsy, by proton magnetic resonance (MR) spectroscopy ((1)H-MRS). METHODS:Eleven BAFME patients from three families showing linkage to 2p11.1-q12.2 were compared wi...

journal_title：Epilepsia

authors： Striano P,Caranci F,Di Benedetto R,Tortora F,Zara F,Striano S

更新日期：2009-06-01 00:00:00

abstract：:We studied 36 drop seizures in 5 patients with myoclonic astatic epilepsy of early childhood (MAEE) with simultaneous split-screen video recording and polygraph. Sixteen were falling attacks and 20 were either less severe attacks exhibiting only deep head nodding or seizures equivalent to drop attacks in terms of icta...

journal_title：Epilepsia

authors： Oguni H,Fukuyama Y,Imaizumi Y,Uehara T

更新日期：1992-09-01 00:00:00