The development of intellectual abilities in pediatric temporal lobe epilepsy.

Abstract:

PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequently underwent surgical resection. The impact of age at onset and duration of epilepsy, pathology type, and side of resection on full-scale intelligence quotient (IQ) scores was examined. RESULTS:Intellectual dysfunction (defined as IQ < 79) was present in 57% of children, and age at onset of epilepsy was the best predictor of intellectual function. Children with epilepsy onset in the first year of life had a particularly high incidence of intellectual impairment (82.4%). CONCLUSION:These data suggest a critical period during the first year of life for the subsequent development of intellectual abilities and highlight the importance of early treatment in this population.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Cormack F,Cross JH,Isaacs E,Harkness W,Wright I,Vargha-Khadem F,Baldeweg T

doi

10.1111/j.1528-1167.2006.00904.x

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

201-4

issue

1

eissn

0013-9580

issn

1528-1167

pii

EPI904

journal_volume

48

pub_type

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