Immunologic aspects of carbamazepine treatment in epileptic patients.

abstract：:Development of new excitatory connectivity and decreases in γ-aminobutyric acid (GABA)ergic inhibition are mechanisms underlying posttraumatic epileptogenesis in animal models. Experimental strategies that interfere with these processes, applied between the trauma and seizure onset, are antiepileptogenic in the labora...

journal_title：Epilepsia

authors： Prince DA,Parada I,Li H,McDonald W,Graber K

更新日期：2010-12-01 00:00:00

abstract：:Seizure prevalence among school age children residing in a rural western Kentucky area (Hardin County) was determined utilizing a method designed to minimize false positives and to allow estimation of false negatives. The observed prevalence of epilepsy is 5.7/1,000 and of febrile seizures 17/1,000. Because of the hig...

journal_title：Epilepsia

authors： Baumann RJ,Marx MB,Leonidakis MG

更新日期：1978-02-01 00:00:00

abstract：PURPOSE:The aim of this prospective incident community-based study was to assess the influence of pre- and perinatal risk factors in children in whom an unprovoked afebrile epileptic seizure later developed. METHODS:From November 1, 1985, until June 30, 1987, 75 children aged 0-15 years with a first unprovoked afebril...

journal_title：Epilepsia

authors： Sidenvall R,Heijbel J,Blomquist HK,Nyström L,Forsgren L

更新日期：2001-10-01 00:00:00

abstract：:Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-li...

journal_title：Epilepsia

authors： Fueta Y,Siniscalchi A,Tancredi V,Avoli M

更新日期：1995-04-01 00:00:00

abstract：:The anticonvulsant and motor effects of gabapentin (GBP) were evaluated in rat pups aged 16-17 days. Fourteen-day-old rat pups received an implanted stimulating electrode in the amygdala unilaterally. Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala...

journal_title：Epilepsia

authors： Lado FA,Sperber EF,Moshé SL

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:We evaluated the dose-related impacts of tiagabine (TGB) on cognition and mood in a monotherapy study. METHODS:Patients were 123 adults with uncontrolled partial seizures, each treated with a single currently available antiepileptic drug (AED) for management of clinical epilepsy. They completed a battery of ne...

journal_title：Epilepsia

authors： Dodrill CB,Arnett JL,Shu V,Pixton GC,Lenz GT,Sommerville KW

更新日期：1998-01-01 00:00:00

abstract：:We determined the incidence of seizures due to acute CNS insults for residents of Rochester, Minnesota, U.S.A., from 1935 through 1984. The age-adjusted incidence rates for 1955-1984, the period of most complete case ascertainment, was 39.0/100,000 person-years (United States 1970 population as standard). The age-adju...

journal_title：Epilepsia

authors： Annegers JF,Hauser WA,Lee JR,Rocca WA

更新日期：1995-04-01 00:00:00

abstract：:We sought to determine if there are differences in the incidence of seizure disorders between the children of the indigenous and immigrant (predominantly Pakistani) populations of Bradford, United Kingdom. Annual incidence rates per 100,000 for new onset seizures were calculated along with Townsend deprivation scores....

journal_title：Epilepsia

authors： Hamdy NA,Ginby D,Feltbower R,Ferrie CD

更新日期：2007-05-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:The possibility that a recent seizure or a recent change in antiepileptic medication might produce an occult change in neuropsychological performance is of interest, and especially so in the context of evaluation for epilepsy surgery. Such an evaluation is often done in a setting of video-EEG monitoring where a...

journal_title：Epilepsia

authors： Dodrill CB,Ojemann GA

更新日期：2007-10-01 00:00:00

abstract：:[3H]Nimodipine and high-affinity [125I]omega-conotoxin GVIA (CgTX) binding were investigated in membranes from rat cerebral cortex, cerebellum, and hippocampus after electrically and chemically induced seizures. Animals were decapitated 30 min after a single electroconvulsive shock (ECS) or lidocaine-induced seizure a...

journal_title：Epilepsia

authors： Gleiter CH,Cain CJ,Weiss SR,Post RM,Marangos PJ

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To determine whether differences in clinical manifestations of psychogenic nonepileptic events are associated with differences in outcome and whether the length of illness before diagnosis correlates with outcome. METHODS:We reviewed ictal videotapes and EEGs in 85 patients diagnosed with exclusively nonepilep...

journal_title：Epilepsia

authors： Selwa LM,Geyer J,Nikakhtar N,Brown MB,Schuh LA,Drury I

更新日期：2000-10-01 00:00:00

abstract：:This essay explores the usefulness of the concept of consciousness in epileptology and concludes that it does not further the understanding of seizure mechanisms and brain function. The reasons for this are both theoretical and empirical. Consciousness cannot be adequately defined. This may explain why attempts at acc...

journal_title：Epilepsia

authors： Gloor P

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To evaluate the antiepileptic and neuroprotective properties of topiramate (TPM) alone and with coadministration of the N-methyl-D-aspartate (NMDA)-receptor antagonist budipine in a rat model of refractory status epilepticus. METHODS:Male Sprague-Dawley rats had electrodes implanted into the perforant path and...

journal_title：Epilepsia

authors： Fisher A,Wang X,Cock HR,Thom M,Patsalos PN,Walker MC

更新日期：2004-11-01 00:00:00

abstract：:The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...

journal_title：Epilepsia

authors： Helgason CM,Bergen D,Bleck TP,Morrell F,Whisler W

更新日期：1987-07-01 00:00:00

abstract：PURPOSE:Patients with tuberous sclerosis complex (TSC) often have severe epilepsy that is intractable to available therapies. The development of novel treatments for epilepsy in TSC would benefit greatly from a suitable animal model, but most animal models of TSC to date have few reported neurological abnormalities, su...

journal_title：Epilepsia

authors： Erbayat-Altay E,Zeng LH,Xu L,Gutmann DH,Wong M

更新日期：2007-08-01 00:00:00

abstract：:The anticonvulsant and toxic properties of methyl 4-[(p-chlorophenyl)amino]-6-methyl-2-oxocyclohex-3-en-1-oate (ADD 196022), were compared with those of phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA). These compounds were evaluated in mice and rats using well-standardized anticonvulsant testing procedures. ...

journal_title：Epilepsia

authors： Mulzac D,Scott KR

更新日期：1993-11-01 00:00:00

abstract：:The effect of short-term withdrawal of antiepileptic drugs (AEDs) on auditory event-related potentials (ERPs) was studied in 16 patients undergoing preoperative evaluation for epilepsy surgery. ERPs were performed for all patients during treatment with full medication and after a 1-week period during ongoing tapering ...

journal_title：Epilepsia

authors： Tuunainen A,Nousiainen U,Pilke A,Mervaala E,Riekkinen P

更新日期：1995-03-01 00:00:00

abstract：:A double-blind, randomized, cross-over study of additional vigabatrin (gamma-vinyl-GABA, VGB, 1.0 g twice daily for 6 weeks, followed by 1.5 g twice daily for 6 weeks) and matched placebo was undertaken in 24 patients with refractory epilepsy. Nineteen completed the trial satisfactorily. Fewer seizure days were report...

journal_title：Epilepsia

authors： McKee PJ,Blacklaw J,Friel E,Thompson GG,Gillham RA,Brodie MJ

更新日期：1993-09-01 00:00:00

abstract：:We report the history of a 14-year-old girl with atypical childhood occipital epilepsy "Gastaut type" whose first generalized tonic-clonic seizure was preceded by migraine without aura and followed by a status migrainosus. This status lasted for 3 days despite standard analgesic therapy. An EEG recording revealed an o...

journal_title：Epilepsia

authors： Parisi P,Kasteleijn-Nolst Trenité DG,Piccioli M,Pelliccia A,Luchetti A,Buttinelli C,Villa MP

更新日期：2007-11-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Autoantibodies against glutamic acid decarboxylase (GAD) and the voltage-gated potassium channel (VGKC) complex are associated with distinct subtypes of limbic encephalitis regarding clinical presentation, response to therapy, and outcome. The aim of this study was to investigate white matter changes in these...

journal_title：Epilepsia

authors： Wagner J,Schoene-Bake JC,Witt JA,Helmstaedter C,Malter MP,Stoecker W,Probst C,Weber B,Elger CE

更新日期：2016-03-01 00:00:00

abstract：:An 8-year-old Chinese girl had a first episode of symptomatic partial epilepsy at age 2 years. Despite regular treatment with antiepileptic drugs (AEDs), the seizures remitted and exacerbated. Epileptiform EEG discharges were evident, arising from the left centroparietal region. Magnetic resonance imaging (MRI) and co...

journal_title：Epilepsia

authors： Wang PJ,Liu HM,Young C,Lin MY,Shen YZ

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of multiple subpial transection (MST), a new technique in epilepsy surgery, alone and in combination with resection. METHODS:MST was performed in 22 patients with intractable epilepsy, 10 of whom were treated with a combination of a resection and MST in functionally important ...

journal_title：Epilepsia

authors： Hufnagel A,Zentner J,Fernandez G,Wolf HK,Schramm J,Elger CE

更新日期：1997-06-01 00:00:00

abstract：:Concentrations of prostaglandins (PGs) in the central nervous system are known to increase during and after experimentally induced seizures. In the present study, concentrations of PGE-2 were determined by radioimmunoassay in lumbar cerebrospinal fluid (CSF) of 17 children shortly after a febrile convulsion. PGE-2 dat...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:To study prospectively the evolution of visual attention in children with West syndrome to evaluate its development before the onset of spasms, its possible deterioration as a consequence of epileptic disorders, and its outcome at the age of 2 years, and the possible relation between the impairment of visual at...

journal_title：Epilepsia

authors： Guzzetta F,Frisone MF,Ricci D,Randò T,Guzzetta A

更新日期：2002-07-01 00:00:00

abstract：:All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

journal_title：Epilepsia

authors： McAreavey MJ,Ballinger BR,Fenton GW

更新日期：1992-07-01 00:00:00

abstract：:Autoantibodies to surface proteins that influence neuronal excitability are increasingly found in different forms of epilepsy or encephalitis in adults, and are also beginning to be identified in children. The conditions are often refractory to traditional antiepileptic drugs. Detection of these antibodies can help to...

journal_title：Epilepsia

authors： Vincent A,Irani SR,Lang B

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), an important research and clinical tool, depends on relatively greater transient increases in (regional cerebral blood flow) rCBF than cerebral metabolic rate for oxygen during neural activity. We investigated whether reduced rest...

journal_title：Epilepsia

authors： Appel S,Duke ES,Martinez AR,Khan OI,Dustin IM,Reeves-Tyer P,Berl MB,Sato S,Gaillard WD,Theodore WH

更新日期：2012-04-01 00:00:00