Abstract:
:Development of new excitatory connectivity and decreases in γ-aminobutyric acid (GABA)ergic inhibition are mechanisms underlying posttraumatic epileptogenesis in animal models. Experimental strategies that interfere with these processes, applied between the trauma and seizure onset, are antiepileptogenic in the laboratory, and have promise for prophylaxis of epileptogenesis after cortical injury in humans. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Prince DA,Parada I,Li H,McDonald W,Graber Kdoi
10.1111/j.1528-1167.2010.02816.xsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
30eissn
0013-9580issn
1528-1167journal_volume
51 Suppl s5pub_type
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