Semiology of temporal lobe seizures: value in lateralizing the seizure focus.

abstract：PURPOSE:This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS:The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [...

journal_title：Epilepsia

authors： Skradski S,White HS

更新日期：2000-01-01 00:00:00

abstract：:In 1990, the NIH Consensus Conference Panel on epilepsy surgery called for the development and use of reliable and valid health-related quality-of-life (HRQOL) measures in epilepsy surgery studies. A HRQOL measure for epilepsy surgery patients has been developed and evaluated. The procedure, which could also be used t...

journal_title：Epilepsia

authors： Vickrey BG

更新日期：1993-01-01 00:00:00

abstract：:In 45 patients suffering from secondary generalized epilepsy, we have recorded 239 drop seizures both by radio-telemetered EEG/split-screen video taping and polygraphically. Twenty of these patients had pure tonic drop seizures. Nine patients each had myoclonic-atonic or pure atonic seizures, whereas seven had slow fa...

journal_title：Epilepsia

authors： Egli M,Mothersill I,O'Kane M,O'Kane F

更新日期：1985-09-01 00:00:00

abstract：:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which ...

journal_title：Epilepsia

authors： Francis PT,Lowe SL,Bowen DM,Jefferys JG

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen le...

journal_title：Epilepsia

authors： Pittau F,Grova C,Moeller F,Dubeau F,Gotman J

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:To describe seizure control, complications, adaptive function and language skills following hemispheric surgery for epilepsy. METHODS:Retrospective chart review of patients who underwent hemispheric surgery from July 1993 to June 2004 with a minimum follow-up of 12 months. RESULTS:The study population compris...

journal_title：Epilepsia

authors： Basheer SN,Connolly MB,Lautzenhiser A,Sherman EM,Hendson G,Steinbok P

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To determine the incidence, duration, risk factors for, and clinical correlates of postictal generalized electroencephalography (EEG) suppression (PGES), and to further delineate the significance of PGES in the pathogenesis of sudden unexpected death in epilepsy (SUDEP). METHODS:We retrospectively reviewed the...

journal_title：Epilepsia

authors： Tao JX,Yung I,Lee A,Rose S,Jacobsen J,Ebersole JS

更新日期：2013-05-01 00:00:00

abstract：:Sudden unexplained death syndrome (SUDS) accounts for about 10% of deaths in patients with epilepsy. It is associated with subtherapeutic postmortem serum antiepileptic drug (AED) levels but no anatomic cause of death on autopsy. The mechanisms of death are not known. We investigated 44 cases of SUDS for details of se...

journal_title：Epilepsia

authors： Earnest MP,Thomas GE,Eden RA,Hossack KF

更新日期：1992-03-01 00:00:00

abstract：:Surgery for seizures arising from the rolandic area can be performed effectively, and accurate mapping of eloquent regions may improve seizure and functional outcome. Noninvasive cortical mapping is, however, hardly feasible in young children. We studied two children with epileptogenic focal cortical dysplasia (FCD) t...

journal_title：Epilepsia

authors： Barba C,Montanaro D,Frijia F,Giordano F,Blümcke I,Genitori L,De Masi F,Guerrini R

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states. METHODS:A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditions (ictal/peri-ictal ...

journal_title：Epilepsia

authors： Hogan RE,Tarquinio D,Sperling MR,Klein P,Miller I,Segal EB,Rabinowicz AL,Carrazana E

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a well-known clinical entity caused by partial deletion of the short arm of one chromosome 4 (4p- syndrome). Seizures occur in almost all the cases, but studies on the electroclinical disorder and its evolution are still scarce. We present a longitudinal study of the electro...

journal_title：Epilepsia

authors： Battaglia D,Zampino G,Zollino M,Mariotti P,Acquafondata C,Lettori D,Pane M,Vasta I,Neri G,Dravet C,Guzzetta F

更新日期：2003-09-01 00:00:00

abstract：:The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...

journal_title：Epilepsia

authors： Helgason CM,Bergen D,Bleck TP,Morrell F,Whisler W

更新日期：1987-07-01 00:00:00

abstract：:Children with malformations of cortical development represent a significant proportion of pediatric epilepsy surgery candidates. From a cohort of 40 children operated on between 1980 and 1992 with malformation of cortical development, 38 were alive and had data 10 years after surgery. Age at surgery ranged from 6 mont...

journal_title：Epilepsia

authors： Hamiwka L,Jayakar P,Resnick T,Morrison G,Ragheb J,Dean P,Dunoyer C,Duchowny M

更新日期：2005-04-01 00:00:00

abstract：:We performed a retrospective study of 51 consecutive patients who underwent operation for intractable partial epilepsy related to low-grade intracerebral neoplasms between 1984 and 1990. All patients had medically refractory partial seizures and a mass lesion identified on neuroimaging studies. Lesionectomy was perfor...

journal_title：Epilepsia

authors： Britton JW,Cascino GD,Sharbrough FW,Kelly PJ

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Drebrins are crucial for synaptic function and dendritic spine development, remodeling, and maintenance. In temporal lobe epilepsy (TLE) patients, a significant hippocampal synaptic reorganization occurs, and synaptic reorganization has been associated with hippocampal hyperexcitability. This study aimed to e...

journal_title：Epilepsia

authors： Dombroski TCD,Peixoto-Santos JE,Maciel K,Baqui MMA,Velasco TR,Sakamoto AC,Assirati JA,Carlotti CG,Machado HR,Sousa GK,Hanamura K,Leite JP,Costa da Costa J,Palmini AL,Paglioli E,Neder L,Spreafico R,Shirao T,Garbelli R

更新日期：2020-08-01 00:00:00

abstract：:We examined the relationship between clinical characteristics and EEG classification in all children with febrile seizures examined at the University Pediatric Clinic, Skopje, Yugoslavia between 1982 and 1984. This is the only facility in Macedonia providing EEG or neurologic consultation for children. EEGs were class...

journal_title：Epilepsia

authors： Sofijanov N,Emoto S,Kuturec M,Dukovski M,Duma F,Ellenberg JH,Hirtz DG,Nelson KB

更新日期：1992-01-01 00:00:00

abstract：:The blood-brain barrier, a unique feature of the cerebral vasculature, is gaining attention as a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy, and schizophrenia. Although acute blood-brain barrier dysfunction can induce cerebral edema, seizures, or neuropsychiatric symptoms...

journal_title：Epilepsia

authors： Schoknecht K,Shalev H

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Upper extremity automatisms are considered to be an ipsilateral seizure lateralizing sign in temporal lobe epilepsy (TLE). Herein we describe different types of contralateral upper extremity automatisms (CUEAs). METHODS:One hundred ninety-three video-(electroencephalography) EEG recordings of 59 patients were ...

journal_title：Epilepsia

authors： Kelemen A,Fogarasi A,Borbély C,Szucs A,Fabó D,Jakus R,Rásonyi G,Halász P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison. METHODS:We conducted a study to estimate the incidence of SUD among subjects y...

journal_title：Epilepsia

authors： Derby LE,Tennis P,Jick H

更新日期：1996-10-01 00:00:00

abstract：:Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

journal_title：Epilepsia

authors： Yasiry Z,Shorvon SD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Neurosurgery is an effective therapy for selected individuals with medically refractory temporal lobe epilepsy (TLE). De novo psychopathology may complicate the postsurgical outcome. Our aims were to identify predictors of de novo psychiatric and seizure outcome following TLE surgery. METHODS:Medical records o...

journal_title：Epilepsia

authors： Cleary RA,Thompson PJ,Fox Z,Foong J

更新日期：2012-10-01 00:00:00

abstract：:Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug-metabolizing enzymes, and ion channels. We r...

journal_title：Epilepsia

authors： Ramachandran V,Shorvon SD

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To assess the visual system excitability of photosensitive patients with idiopathic generalized epilepsy (IGE) with the paired-pulse flash-evoked potential (paired F-VEP) technique. METHODS:We studied 19 photosensitive patients with IGE (16 women) showing a photoparoxysmal electroencephalographic (EEG) respons...

journal_title：Epilepsia

authors： Strigaro G,Prandi P,Varrasi C,Monaco F,Cantello R

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (...

journal_title：Epilepsia

authors： Foldvary-Schaefer N,De Leon Sanchez I,Karafa M,Mascha E,Dinner D,Morris HH

更新日期：2002-12-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:To assess seizure and cognitive outcomes and their predictors in children (<16 years at surgery) and adults undergoing temporal lobe epilepsy (TLE) surgery in eight Italian centers. METHODS:This is a retrospective multicenter study. We performed a descriptive analysis and subsequently carried out multivariab...

journal_title：Epilepsia

authors： Barba C,Cossu M,Guerrini R,Di Gennaro G,Villani F,De Palma L,Grisotto L,Consales A,Battaglia D,Zamponi N,d'Orio P,Revay M,Rizzi M,Casciato S,Esposito V,Quarato PP,Di Giacomo R,Didato G,Pastori C,Pavia GC,Pellacani

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is the most common of the antiepileptic drug (AED)-resistant seizure syndromes that are remediable mostly with surgery, although a small group of patients have benign prognosis with fewer seizures. Material-specific memory impairment ...

journal_title：Epilepsia

authors： Ozkara C,Hanoğlu L,Keskinkiliç C,Yeni N,Aysal F,Uzan M,Ozyurt E,Karaağaç N

更新日期：2004-11-01 00:00:00

abstract：:A 28-year-old man with regularly occurring clusters of complex partial seizures was studied over a total of 224 days. His seizure periods lasted 2-4 days and occurred at intervals of 5-6 weeks. Several parameters were studied. The most striking finding was an increase in the serum concentration of thyroxine prior to a...

journal_title：Epilepsia

authors： Taubøll E,Stokke KT,Gjerstad L,Løyning Y,Johannessen SI

更新日期：1986-07-01 00:00:00

abstract：:Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, a...

journal_title：Epilepsia

authors： Tomson T,Svanborg E,Wedlund JE

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:We report on a quantitative analysis of data from a study that acquired continuous long-term ambulatory human electroencephalography (EEG) data over extended periods. The objectives were to examine the seizure duration and interseizure interval (ISI), their relationship to each other, and the effect of these ...

journal_title：Epilepsia

authors： Cook MJ,Karoly PJ,Freestone DR,Himes D,Leyde K,Berkovic S,O'Brien T,Grayden DB,Boston R

更新日期：2016-03-01 00:00:00