Abstract:
PURPOSE:To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison. METHODS:We conducted a study to estimate the incidence of SUD among subjects younger than 50 years with refractory epilepsy, by using information from the General Practice Research Database (GPRD) in the United Kingdom. For the purposes of this study, subjects receiving two or more anticonvulsant drugs concurrently were considered to have refractory epilepsy. Potential cases of SUD were identified from the computer records, and clinical records for these subjects were reviewed by two specialists in SUD in epilepsy. RESULTS:Fifteen subjects (eight male, seven female) of the 4,150 subjects with refractory epilepsy were considered to have definite/probable or possible SUD. CONCLUSIONS:The overall incidence rate of SUD in the population was 2.2 per 1,000 person-years (95% CI, 1.3-3.6). The rate for subjects with highly probable SUD was 1.5 per 1,000 person-years (95% CI, 0.8-2.7).
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Derby LE,Tennis P,Jick Hdoi
10.1111/j.1528-1157.1996.tb00529.xsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
931-5issue
10eissn
0013-9580issn
1528-1167journal_volume
37pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract:PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2008.01974.x
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03114.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to develop a quantitative framework to estimate the likelihood of multifocal epilepsy based on the number of unifocal seizures observed in the epilepsy monitoring unit (EMU). METHODS:Patient records from the EMU at Massachusetts General Hospital (MGH) from 2012 to 2014 were asse...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13090
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1528-1167.2008.01792.x
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:The goal of the study was to assess the health-related quality of life (HRQOL) of persons with epilepsy (PWE) by using the short form survey 36 (SF-36), to compare it with that of a control group and to detect factors influencing it. METHODS:We collected clinical and demographic data and information on health ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.56903.x
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00418.x
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Polymicrogyria (PMG) is an epileptogenic malformation of cortical development. We describe the clinical epilepsy and imaging features of a large cohort with PMG-related epilepsy. METHODS:Participants were recruited through the Epilepsy Phenome/Genome Project, a multicenter collaborative effort to collect detai...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/epi.12238
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16487
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1997.tb01216.x
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:We examine improvement and worsening in quality of life (QOL) in terms of proportions achieving minimum clinically important change (MCID), and factors related to MCID, in patients with temporal lobe epilepsy randomized to medical or surgical treatment. METHODS:Eighty patients with temporal lobe epilepsy ran...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12625
更新日期:2014-06-01 00:00:00
abstract::Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often brings attention to...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16328
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2001.05901.x
更新日期:2001-10-01 00:00:00
abstract::Study of patients with temporal lobe epilepsy and generalized epilepsy revealed no overall seizure type differences, nor overall age-at-onset effects, on MMPI measures of psychopathology. However, statistically significant interactions between seizure type and age at onset were obtained on several MMPI measures, and s...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1980.tb04040.x
更新日期:1980-02-01 00:00:00
abstract::The availability of generic products of antiepileptic drugs (AEDs) has been increasing in recent years. In view of the importance of the issue, the Italian League against Epilepsy (LICE) set up an ad hoc working group whose task was to assess available evidence on the efficacy and safety of generic AEDs in the treatme...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00871.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16411
更新日期:2020-01-01 00:00:00
abstract::The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1985.tb05656.x
更新日期:1985-07-01 00:00:00
abstract::Sleep is a modulator of seizure activity, and many antiepileptic drugs are modulators of sleep. Can influences on sleep organization be involved in antiepileptic drug action, and can these partly account for differences in drug response of various epileptic syndromes? Much more exact data must be collected before thes...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1528-1157.1984.tb03445.x
更新日期:1984-08-01 00:00:00
abstract::Neurotrophic factors are involved in the survival of neurons as well as in the proliferation and differentiation of neuronal precursors. Therefore, modulating their levels in lesion areas may exert favorable effects on seizure-induced damage. However, it is unclear if damage limitation or repair may prevent epileptoge...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2010.02609.x
更新日期:2010-07-01 00:00:00
abstract::Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12061
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:The aims of the present study were to explore the relation between ictal scalp EEG patterns and ictal hyperperfusion patterns in patients with unilateral hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) by using semiquantitative single-photon emission computed tomography (SPECT) analysis...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00847.x
更新日期:2007-02-01 00:00:00
abstract::Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances. For many years this condition has been associated with the nonepileptic condition of transient global amnesia (TGA) and still...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2009.02124.x
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:Ictal vomiting represents a rare clinical manifestation during seizures originating from the temporal lobes of the nondominant hemisphere. The precise anatomic structures responsible for generation of ictal vomiting remain to be clarified. Ictal single photon emission computed tomography (SPECT), which allows o...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb00823.x
更新日期:1999-08-01 00:00:00
abstract::Little is known about the effects of carbamazepine (CBZ) on sleep despite the relationship between sleep and epilepsy and the common clinical use of CBZ. As part of a larger study on sleep and interictal activity in kindled cats, we performed sleep recordings in 11 normal cats before and after acute administration of ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1988.tb04230.x
更新日期:1988-11-01 00:00:00
abstract::Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote histor...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb00459.x
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:There are limited data on the indications for the use of chronic invasive electroencephalography (EEG) monitoring (IEM) for pediatric epilepsy surgery. METHODS:We retrospectively studied 102 children who underwent intracranial monitoring to map critical cortex, localize the epileptogenic region, or resolve d...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12983
更新日期:2015-07-01 00:00:00
abstract::A need for prevalence information emphasizing racial differences prompted a door-to-door survey of all residents of Copiah County, Mississippi. The fieldwork involved a complete census and an extensive screening questionnaire inquiring about diagnoses, signs, and symptoms of neurologic disease. Residents who lived in ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb03503.x
更新日期:1986-01-01 00:00:00
abstract::Parenteral magnesium sulfate has been used to control acute convulsions of diverse etiologies and is currently a mainstay in controlling eclamptic convulsions. However, the site of this anticonvulsant action has remained controversial and not well studied in experimental epileptic models. Therefore we determined the e...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1978.tb05015.x
更新日期:1978-02-01 00:00:00
abstract::Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5-benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13013
更新日期:2015-06-01 00:00:00
abstract::We examined postoperative changes in the memory function of 68 people with unilateral hippocampal sclerosis (HS) who underwent epilepsy surgery and had no previous clinical memory impairments. One in four with right HS (RHS) and one in five with left HS (LHS) in our sample of 323 people with unilateral HS performed wi...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12319
更新日期:2013-09-01 00:00:00
abstract::The incidence of idiopathic/cryptogenic epilepsy and isolated unprovoked seizures has been relatively stable in the population of Rochester, Minnesota, for the 50-year period 1935 through 1984. In each decade, the age-specific rates exhibited a consistent U-shaped pattern of decreasing rates from infancy to age 40-49 ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb02570.x
更新日期:1995-06-01 00:00:00