Effect of magnesium on epileptic foci.

abstract：:The effects of antiepileptic drugs (AEDs) on cognitive function and behavior in children are reviewed on the basis of published studies. Individual AEDs have been shown to differ--the deleterious effects of phenytoin generally contrasting with the relatively minimal effects of valproate and carbamazepine. Some of the ...

journal_title：Epilepsia

authors： Trimble MR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:It has been suggested that multilobar epilepsies caused by lesions restricted to the posterior cerebral quadrant (ie, the parietal, temporal, and occipital lobes) can be treated successfully by a procedure termed posterior disconnection. The objective of the present paper was to identify determinants of the e...

journal_title：Epilepsia

authors： Kalbhenn T,Cloppenborg T,Wörmann FG,Blümcke I,Coras R,May TW,Polster T,Simon M,Bien CG

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To clarify the electroclinical manifestation of epileptic seizures and the evolution of epilepsy in patients with peroxisomal diseases. METHODS:Retrospective review of the medical records and EEGs of 14 patients with peroxisomal diseases: seven with Zellweger syndrome (ZS), two with neonatal adrenoleukodystrop...

journal_title：Epilepsia

authors： Takahashi Y,Suzuki Y,Kumazaki K,Tanabe Y,Akaboshi S,Miura K,Shimozawa N,Kondo N,Nishiguchi T,Terada K,Orii T

更新日期：1997-02-01 00:00:00

abstract：:Reliably detecting focal seizures without secondary generalization during daily life activities, chronically, using convenient portable or wearable devices, would offer patients with active epilepsy a number of potential benefits, such as providing more reliable seizure count to optimize treatment and seizure forecast...

journal_title：Epilepsia

authors： Ryvlin P,Cammoun L,Hubbard I,Ravey F,Beniczky S,Atienza D

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To evaluate safety and tolerability of ketogenic diet (KGD) and valproate (VPA) cotherapy in the treatment of intractable seizures. METHODS:The patient records of children who underwent KGD initiation at the Massachusetts General Hospital for Children from February 2002 to September 2004 were retrospectively a...

journal_title：Epilepsia

authors： Lyczkowski DA,Pfeifer HH,Ghosh S,Thiele EA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Prior studies have given conflicting data concerning the association of benign rolandic epilepsy of childhood (BREC) and migraine but were limited by lack of sensitive, diagnostic criteria for childhood migraine. By using revised International Headache Society (IHS-R) criteria, we compared the prevalence of mig...

journal_title：Epilepsia

authors： Wirrell EC,Hamiwka LD

更新日期：2006-10-01 00:00:00

abstract：:The presence of the excitotoxic and convulsant agent quinolinic acid (QUIN) in human brain has led to the hypothesis that an increase of this tryptophan metabolite could serve as an endogenous epileptogen. A possible mechanism for a pathological accumulation of QUIN being a deficiency in its degradation, we have measu...

journal_title：Epilepsia

authors： Feldblum S,Rougier A,Loiseau H,Loiseau P,Cohadon F,Morselli PL,Lloyd KG

更新日期：1988-09-01 00:00:00

abstract：:We studied a 41-year-old woman who had nocturnal somatosensory seizures followed by orgasm. The interictal EEG showed discrete left central parietal region paroxysmal activity that markedly increased during sleep. Eight electroclinical seizures were recorded during sleep polygraphic recording. Orgasms occurred coincid...

journal_title：Epilepsia

authors： Calleja J,Carpizo R,Berciano J

更新日期：1988-09-01 00:00:00

abstract：:The anticonvulsant and motor effects of gabapentin (GBP) were evaluated in rat pups aged 16-17 days. Fourteen-day-old rat pups received an implanted stimulating electrode in the amygdala unilaterally. Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala...

journal_title：Epilepsia

authors： Lado FA,Sperber EF,Moshé SL

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...

journal_title：Epilepsia

authors： Leary LD,Wang D,Nordli DR Jr,Engelstad K,De Vivo DC

更新日期：2003-05-01 00:00:00

abstract：:The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...

journal_title：Epilepsia

authors： Annegers JF,Baumgartner KB,Hauser WA,Kurland LT

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...

journal_title：Epilepsia

authors： Simone IL,Federico F,Tortorella C,De Blasi R,Bellomo R,Lucivero V,Carrara D,Bellacosa A,Livrea P,Carella A

更新日期：1999-07-01 00:00:00

abstract：:We set out to review the extent to which molecular karyotyping has overtaken conventional cytogenetics in applications related to epilepsy. Multiplex ligase-dependent probe amplification (MLPA) targeted to predetermined regions such as SCN1A and KCNQ2 has been effectively applied over the last half a decade, and oligo...

journal_title：Epilepsia

authors： Mulley JC,Mefford HC

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP). METHODS:Male Wistar rats, stereotactically implanted in both ventral hip...

journal_title：Epilepsia

authors： Cuellar-Herrera M,Peña F,Alcantara-Gonzalez D,Neri-Bazan L,Rocha L

更新日期：2010-03-01 00:00:00

abstract：:We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG di...

journal_title：Epilepsia

authors： Kumlien E,Bergström M,Lilja A,Andersson J,Szekeres V,Westerberg CE,Westerberg G,Antoni G,Långström B

更新日期：1995-07-01 00:00:00

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To analyze activity of identified dentate gyrus granular cells and interneurons during pathologic high-frequency oscillations (pHFOs). METHODS:Pilocarpine-treated epileptic mice were anesthetized with urethane and ketamine. Their heads were fixed in a stereotaxic frame. Extracellular unit activity was recoded ...

journal_title：Epilepsia

authors： Bragin A,Benassi SK,Kheiri F,Engel J Jr

更新日期：2011-01-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：:The practice of epileptology at a molecular level, where gene products are identified by gene mapping, will soon be possible for a growing number of epilepsies. Juvenile myoclonic epilepsy (JME) is the first of such epilepsies to be mapped to a chromosome, namely chromosome 6p21.3. Family studies of 68 JME probands fr...

journal_title：Epilepsia

authors： Delgado-Escueta AV,Greenberg DA,Treiman L,Liu A,Sparkes RS,Barbetti A,Park MS,Terasaki PI

更新日期：1989-01-01 00:00:00

abstract：:Traditionally, control of seizures in patients with epilepsy is viewed as the most important clinical outcome. Yet, current antiepileptic drugs (AEDs) do not always achieve this. Around 30-40% of patients remain uncontrolled despite pharmacological intervention. Poor tolerability of AEDs is a large part of the problem...

journal_title：Epilepsia

authors： Bazil CW

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The present study aimed to clarify the effect of electrical stimulation and lesioning of the anterior nucleus of the thalamus (ANT) on kainic acid (KA)-induced focal cortical seizures in a rat model. To address the mechanism underlying these anticonvulsant actions, cerebral glucose metabolism after ANT electric...

journal_title：Epilepsia

authors： Takebayashi S,Hashizume K,Tanaka T,Hodozuka A

更新日期：2007-02-01 00:00:00

abstract：:We report identical twins with supernumerary ring chromosome 19 mosaicism, who had severe refractory epilepsy at an early age. The epilepsy was dominated largely by severe life-threatening tonic seizures. Both twins died, likely as a consequence of their severe epilepsy. They displayed no dysmorphic features. Eight ca...

journal_title：Epilepsia

authors： Shahwan A,Green AJ,Carey A,Stallings RL,O'Flaherty OC,King MD

更新日期：2004-08-01 00:00:00

abstract：:HIPDM-Single photon emission computed tomography brain imaging was performed during interictal and ictal stages in three patients with complex partial seizures and secondarily generalized tonic-clonic seizures. In all three patients, interictal studies demonstrated decreased regional cerebral perfusion (rCP) and ictal...

journal_title：Epilepsia

authors： Lee BI,Markand ON,Wellman HN,Siddiqui AR,Mock B,Krepshaw J,Kung H

更新日期：1987-05-01 00:00:00

abstract：:Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immun...

journal_title：Epilepsia

authors： Pacifici R,Paris L,Di Carlo S,Pichini S,Zuccaro P

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...

journal_title：Epilepsia

authors： Tu K,Wang M,Jaakkimainen RL,Butt D,Ivers NM,Young J,Green D,Jetté N

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...

journal_title：Epilepsia

authors： Kim JA,Yoon JR,Lee EJ,Lee JS,Kim JT,Kim HD,Kang HC

更新日期：2016-01-01 00:00:00

abstract：:Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology-based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Trache...

journal_title：Epilepsia

authors： Yuan F,Gao Q,Jiang W

更新日期：2018-10-01 00:00:00