The effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal cortical seizure status in rats.

abstract：:Polypharmacy is a widely employed treatment strategy in epilepsy, particularly for individuals with poorly controlled seizures. Drug combinations should be carefully considered to minimize the potential for unfavorable interactions. Older-generation antiepileptic drugs (AEDs) are well known for their pharmacokinetic i...

journal_title：Epilepsia

authors： Sills G,Brodie M

更新日期：2007-03-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To clarify the electroclinical manifestation of epileptic seizures and the evolution of epilepsy in patients with peroxisomal diseases. METHODS:Retrospective review of the medical records and EEGs of 14 patients with peroxisomal diseases: seven with Zellweger syndrome (ZS), two with neonatal adrenoleukodystrop...

journal_title：Epilepsia

authors： Takahashi Y,Suzuki Y,Kumazaki K,Tanabe Y,Akaboshi S,Miura K,Shimozawa N,Kondo N,Nishiguchi T,Terada K,Orii T

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...

journal_title：Epilepsia

authors： Drane DL,Loring DW,Voets NL,Price M,Ojemann JG,Willie JT,Saindane AM,Phatak V,Ivanisevic M,Millis S,Helmers SL,Miller JW,Meador KJ,Gross RE

更新日期：2015-01-01 00:00:00

abstract：:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-04-01 00:00:00

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：:In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography (PET) using a radiotracer sensitive to brain inflammation in a patient with frontal epilepsy ~36 h after a seizure as well as during a se...

journal_title：Epilepsia

authors： Butler T,Li Y,Tsui W,Friedman D,Maoz A,Wang X,Harvey P,Tanzi E,Morim S,Kang Y,Mosconi L,Talos D,Kuzniecky R,Vallhabjosula S,Thesen T,Glodzik L,Ichise M,Silbersweig D,Stern E,de Leon MJ,French J

更新日期：2016-09-01 00:00:00

abstract：:Neurotrophic factors are involved in the survival of neurons as well as in the proliferation and differentiation of neuronal precursors. Therefore, modulating their levels in lesion areas may exert favorable effects on seizure-induced damage. However, it is unclear if damage limitation or repair may prevent epileptoge...

journal_title：Epilepsia

authors： Simonato M,Zucchini S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Lennox-Gastaut syndrome (LGS) is a severe epileptic condition characterized by multiple seizure types including tonic seizures, slow spike-and-wave discharges on electroencephalography (EEG), and cognitive impairment. LGS can occur in apparently healthy subjects or in patients with preexisting brain damage. The...

journal_title：Epilepsia

authors： Ferlazzo E,Adjien CK,Guerrini R,Calarese T,Crespel A,Elia M,Striano P,Gelisse P,Bramanti P,di Bella P,Genton P

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Assumptions regarding the benefits of seizure control after pediatric epilepsy surgery for cognitive, psychosocial, and family function were explored in a prospective study of 51 children with intractable epilepsy. METHODS:Thirty children who underwent surgery were studied before and 1 year after surgery, and ...

journal_title：Epilepsia

authors： Smith ML,Elliott IM,Lach L

更新日期：2004-06-01 00:00:00

abstract：:The progressive myoclonus epilepsies (PMEs) are a group of rare genetic disorders previously shrouded in nosological confusion. Recent advances have clarified the features of these disorders and provided a rational approach to diagnosis. The major causes of PME are now known to be Unverricht-Lundborg disease, myoclonu...

journal_title：Epilepsia

authors： Berkovic SF,Cochius J,Andermann E,Andermann F

更新日期：1993-01-01 00:00:00

abstract：:Treatment with sodium valproate (VPA) in association with phenobarbital (PB) is accompanied by a greater systemic hyperammonemia than treatment by VPA alone. The anatomical origins of this difference were studied by injecting a dose of 1,500 mg VPA i.v. into six unmedicated patients and six epileptics chronically trea...

journal_title：Epilepsia

authors： Warter JM,Marescaux C,Brandt C,Rumbach L,Micheletti G,Chabrier G,Imler M,Kurtz D

更新日期：1983-10-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f) quinoxaline-2,3-dione) and topiramate (TPM) given after hypoxia-induced seizures in preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and neuronal injury. METHODS:We used "two-hit" rodent seizure model t...

journal_title：Epilepsia

authors： Koh S,Tibayan FD,Simpson JN,Jensen FE

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To determine the long-term cognitive and educational outcomes in children prospectively identified at the time of a first unprovoked seizure. METHODS:A cohort of children with a first unprovoked seizure was enrolled and followed for a mean of 15 years. Cognitive function and educational outcomes were determine...

journal_title：Epilepsia

authors： Sogawa Y,Masur D,O'Dell C,Moshe SL,Shinnar S

更新日期：2010-12-01 00:00:00

abstract：:Nonepileptic seizures (NES) are neuropsychiatric disorders presenting with a combination of neurologic signs and underlying psychological conflicts. For more than a century, the medical community has accumulated data and insights about the phenomenology, epidemiology, risks, comorbidities, and prognosis of NES. Howeve...

journal_title：Epilepsia

authors： LaFrance WC Jr,Devinsky O

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To present new information on the semiology and short-term evolution of seizures associated with primary brain tumors (PBTs) in a prospective study. METHODS:This study is a section of the PERNO study--Project of Emilia Romagna Region on Neuro-Oncology, the main aim of which is to collect prospectively all case...

journal_title：Epilepsia

authors： Michelucci R,Pasini E,Meletti S,Fallica E,Rizzi R,Florindo I,Chiari A,Monetti C,Cremonini AM,Forlivesi S,Albani F,Baruzzi A,PERNO Study Group.

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:To prospectively investigate the incidence of interictal psychoses of epilepsy patients, and make a comparison between those with interictal psychoses and patients with schizophrenia in respect to their responses to antipsychotic drugs, as well as psychotic states. METHODS:We undertook a two-part prospective i...

journal_title：Epilepsia

authors： Tadokoro Y,Oshima T,Kanemoto K

更新日期：2007-12-01 00:00:00

abstract：:Concentrations of prostaglandins (PGs) in the central nervous system are known to increase during and after experimentally induced seizures. In the present study, concentrations of PGE-2 were determined by radioimmunoassay in lumbar cerebrospinal fluid (CSF) of 17 children shortly after a febrile convulsion. PGE-2 dat...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1988-05-01 00:00:00

abstract：:Accurate identification of cortical malformations in children with epilepsy can be crucial for successful clinical management. Although standard head-coil magnetic resonance imaging (MRI) at 1.5 tesla (T) can be used to view the macrostructure of the brain, phased array technology at both 1.5 and 3T significantly impr...

journal_title：Epilepsia

authors： Grant PE

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported. To elucidate the putative association between FBM and aplastic anemia, we made a detailed evaluation of...

journal_title：Epilepsia

authors： Kaufman DW,Kelly JP,Anderson T,Harmon DC,Shapiro S

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:Quantitative measurement of hippocampal volume using structural magnetic resonance imaging (MRI) is a valuable tool for detection and lateralization of mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE). We compare two automated hippocampal volume methodologies and manual hippocampal volumetry to d...

journal_title：Epilepsia

authors： Pardoe HR,Pell GS,Abbott DF,Jackson GD

更新日期：2009-12-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of medically intractable epilepsy. FCDs are characterized by local architectural disturbances of the neocortex and often by a blurred gray-white matter boundary indicating abnormal white matter myelination. We...

journal_title：Epilepsia

authors： Donkels C,Peters M,Fariña Núñez MT,Nakagawa JM,Kirsch M,Vlachos A,Scheiwe C,Schulze-Bonhage A,Prinz M,Beck J,Haas CA

更新日期：2020-01-01 00:00:00

abstract：:Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of v...

journal_title：Epilepsia

authors： Meldrum BS

更新日期：1997-01-01 00:00:00

abstract：:Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical management of this lesion have motivated the development of laser interstitial thermal therapy (LITT) as a less invasive treatment approach to the d...

journal_title：Epilepsia

authors： Du VX,Gandhi SV,Rekate HL,Mehta AD

更新日期：2017-06-01 00:00:00

abstract：:Between 1929 and 1980, 284 patients with refractory nontumoral frontal lobe epilepsy (FLE) underwent operation at the Montreal Neurological Institute (MNI). We studied 39 patients (14%) who required reoperation. Mean age at the time of first operation was 18 years and at reoperation was 22 years. Clinical manifestatio...

journal_title：Epilepsia

authors： Salanova V,Quesney LF,Rasmussen T,Andermann F,Olivier A

更新日期：1994-01-01 00:00:00

abstract：:We determined the incidence of seizures due to acute CNS insults for residents of Rochester, Minnesota, U.S.A., from 1935 through 1984. The age-adjusted incidence rates for 1955-1984, the period of most complete case ascertainment, was 39.0/100,000 person-years (United States 1970 population as standard). The age-adju...

journal_title：Epilepsia

authors： Annegers JF,Hauser WA,Lee JR,Rocca WA

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:  Preclinical data have suggested that selective serotonin reuptake inhibitors (SSRIs) may have anticonvulsant properties, and some SSRIs are known to modulate ion channels in vitro. We screened citalopram, fluoxetine, and sertraline for anticonvulsant actions in mouse hippocampal slices, and studied the effect...

journal_title：Epilepsia

authors： Igelström KM,Heyward PM

更新日期：2012-11-01 00:00:00

abstract：:To improve the diagnostic accuracy of electroencephalography (EEG) criteria for nonconvulsive status epilepticus (NCSE), external validation of the recently proposed Salzburg criteria is paramount. We performed an external, retrospective, diagnostic accuracy study of the Salzburg criteria, using EEG recordings from pa...

journal_title：Epilepsia

authors： Goselink RJM,van Dillen JJ,Aerts M,Arends J,van Asch C,van der Linden I,Pasman J,Saris CGJ,Zwarts M,van Alfen N

更新日期：2019-08-01 00:00:00