Comparison of the effects of valproate, ethosuximide, phenytoin, and pentobarbital on cerebral energy metabolism in the rat.

abstract：PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequent...

journal_title：Epilepsia

authors： Cormack F,Cross JH,Isaacs E,Harkness W,Wright I,Vargha-Khadem F,Baldeweg T

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：:Seizures cannot be medically controlled in approximately 40% of people with epilepsy. Although we are beginning to understand how to better treat certain seizure types, we still do not know the regulatory events that determine antiepileptic drug resistance. Proposed pathoetiologic mechanisms include altered expression...

journal_title：Epilepsia

authors： Kobow K,El-Osta A,Blümcke I

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Nuclear receptors and cytochrome P450 (CYP) regulate hepatic metabolism of several drugs. Nuclear receptors are expressed at the neurovascular unit of patients with drug-resistant epilepsy. We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain endothelial cells (EPI-...

journal_title：Epilepsia

authors： Ghosh C,Hossain M,Mishra S,Khan S,Gonzalez-Martinez J,Marchi N,Janigro D,Bingaman W,Najm I

更新日期：2018-11-01 00:00:00

abstract：:Since it was originally described nearly 70 years ago, insular epilepsy has been increasingly recognized and may explain failures after apparently well-planned operations. We review the history of awareness of the phenomenon, techniques for its assessment, and its surgical management. Insular epilepsy can mimic featur...

journal_title：Epilepsia

authors： Laoprasert P,Ojemann JG,Handler MH

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To describe a previously unreported type of self-induced pattern-sensitive seizures in a child. METHODS:Evaluation of clinical and EEG features. RESULTS:An 18-month-old boy was initially seen with series of short focal tonic seizures self-induced by gazing intermittently at round objects. Self-induction of th...

journal_title：Epilepsia

authors： Brockmann K,Huppke P,Karenfort M,Gärtner J,Höger C

更新日期：2005-05-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rCRF) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. Such an effect was still present in rats neonatally treated with saline but was absent in...

journal_title：Epilepsia

authors： Marrosu F,Argiolas A,Carcangiu P,Giagheddu M,Fratta W

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Prior studies have given conflicting data concerning the association of benign rolandic epilepsy of childhood (BREC) and migraine but were limited by lack of sensitive, diagnostic criteria for childhood migraine. By using revised International Headache Society (IHS-R) criteria, we compared the prevalence of mig...

journal_title：Epilepsia

authors： Wirrell EC,Hamiwka LD

更新日期：2006-10-01 00:00:00

abstract：:The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1985-07-01 00:00:00

abstract：:Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for ...

journal_title：Epilepsia

authors： Moyer JT,Gnatkovsky V,Ono T,Otáhal J,Wagenaar J,Stacey WC,Noebels J,Ikeda A,Staley K,de Curtis M,Litt B,Galanopoulou AS

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD. METHODS:We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verifi...

journal_title：Epilepsia

authors： Srikijvilaikul T,Najm IM,Hovinga CA,Prayson RA,Gonzalez-Martinez J,Bingaman WE

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...

journal_title：Epilepsia

authors： Strzelczyk A,Cenusa M,Bauer S,Hamer HM,Mothersill IW,Grunwald T,Hillenbrand B,Ebner A,Steinhoff BJ,Krämer G,Rosenow F

更新日期：2011-06-01 00:00:00

abstract：:The effects of carbamazepine (CBZ) monotherapy on serum sex hormone levels and on pituitary responsiveness to various stimuli were evaluated in a prospective study with 21 male patients with epilepsy. The serum levels of testosterone (T), free testosterone (FT), sex hormone binding globulin (SHBG), estradiol (E2), lut...

journal_title：Epilepsia

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1989-07-01 00:00:00

abstract：:Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We therefore conducted a prospective longitudinal study to assess ...

journal_title：Epilepsia

authors： Kim DW,Lee SY,Shon YM,Kim JH

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures. It is known that metabolic crises in affected patients are precipitated by infections. Although growing evidence supports that inflammation facilitates sei...

journal_title：Epilepsia

authors： Salvadori MG,Banderó CR,Jesse AC,Gomes AT,Rambo LM,Bueno LM,Bortoluzzi VT,Oliveira MS,Mello CF

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. METHODS:We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analys...

journal_title：Epilepsia

authors： Loesch AM,Steger H,Losher C,Hartl E,Rémi J,Vollmar C,Noachtar S

更新日期：2017-09-01 00:00:00

abstract：:Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immun...

journal_title：Epilepsia

authors： Pacifici R,Paris L,Di Carlo S,Pichini S,Zuccaro P

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...

journal_title：Epilepsia

authors： Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Studies have found that affected individuals who believe the cause of their disorder is genetic may react in various ways, including optimism for improved treatments and pessimism due to perceived permanence of the condition. This study assessed the psychosocial impact of genetic attribution among people with...

journal_title：Epilepsia

authors： Garofalo DC,Sorge ST,Hesdorffer DC,Winawer MR,Phelan JC,Chung WK,Ottman R

更新日期：2019-11-01 00:00:00

abstract：:Cinromide (BW-122U) was evaluated in an open pilot study of absence seizures in three naive (previously untreated for absence seizures) patients (one male and two females, 7 to 8 years of age). In these naive patients, cinromide was found to be well tolerated but ineffective in reducing generalized spike-and-wave disc...

journal_title：Epilepsia

authors： Corwin HM,Dreifuss FE

更新日期：1983-08-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：:Management of epilepsy in the elderly requires understanding of the unique biochemical and pharmacologic characteristics of this patient population. Accurate assessment of seizures and identification of epilepsy syndromes, thorough neurologic assessment to define etiology, and comprehensive evaluation of the patient's...

journal_title：Epilepsia

authors： Willmore LJ

更新日期：1995-01-01 00:00:00

abstract：:Two healthy male volunteers received 10 mg carbamazepine (CBZ) as a 2-h constant-rate intravenous (i.v.) infusion and 100 mg 15N-labeled CBZ as a 2% oral suspension, concomitantly. The two compounds have identical pharmacokinetics. Their respective concentrations in plasma were determined by gas chromatography-mass sp...

journal_title：Epilepsia

authors： Gérardin A,Dubois JP,Moppert J,Geller L

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:The standard practice of switching patients to carbamazepine (CBZ) involves initiating a low dose and raising it by small increments until the desired dose is reached, to avoid intolerable adverse effects (AE). In a pilot study, a protocol using single-dose kinetic studies was developed to switch patients to CB...

journal_title：Epilepsia

authors： Kanner AM,Bourgeois BF,Hasegawa H,Hutson P

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant action of a gamma-aminobutyric acid (GABA) uptake inhibitor NNC-711 in two models of cortical epileptogenesis in immature rats. METHODS:Twelve-, 18-, and 25-day-old rat pups with implanted electrodes were used in this study. Epileptogenic foci were elicited by a local application of...

journal_title：Epilepsia

authors： Bernásková K,Slamberová R,Mares P

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:Univerricht-Lundborg disease (ULD), with its major symptom of action myoclonus, is supposed to be very rare in the Netherlands and western Europe. We hypothesized that the syndrome may be underdiagnosed in patients with myoclonus epilepsy. METHODS:Mutation analysis of the cystatin B gene was performed in 21 ca...

journal_title：Epilepsia

authors： de Haan GJ,Halley DJ,Doelman JC,Geesink HH,Augustijn PB,Jager-Jongkind AD,Majoie M,Bader AJ,Leliefeld-Ten Doeschate LA,Deelen WH,Bertram E,Lehesjoki AE,Lindhout D

更新日期：2004-09-01 00:00:00

abstract：:Concentrations of prostaglandins (PGs) in the central nervous system are known to increase during and after experimentally induced seizures. In the present study, concentrations of PGE-2 were determined by radioimmunoassay in lumbar cerebrospinal fluid (CSF) of 17 children shortly after a febrile convulsion. PGE-2 dat...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1988-05-01 00:00:00

abstract：:The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

journal_title：Epilepsia

authors： Goodman JH,Homan RW,Crawford IL

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:Unresolved past stressful events can induce a state of vulnerability to epilepsy and comorbidities. Using an experimental model of stress-induced vulnerability to depression, we tested whether an antioxidant treatment applied after the onset of epileptogenesis was disease modifying and could prevent the occur...

journal_title：Epilepsia

authors： Becker C,Mancic A,Ghestem A,Poillerat V,Claverie D,Bartolomei F,Brouillard F,Benoliel JJ,Bernard C

更新日期：2019-04-01 00:00:00