Different neurophysiologic patterns of myoclonus characterize Lennox-Gastaut syndrome and myoclonic astatic epilepsy.

abstract：:The incidence of epilepsy and of all unprovoked seizures was determined for residents of Rochester, Minnesota U.S.A. from 1935 through 1984. Age-adjusted incidence of epilepsy was 44 per 100,000 person-years. Incidence in males was significantly higher than in females and was high in the first year of life but highest...

journal_title：Epilepsia

authors： Hauser WA,Annegers JF,Kurland LT

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:Benzodiazepines (BZD) are recommended as first-line treatment for status epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used drugs and part of current treatment guidelines. Clonazepam (CLZ) is also utilized in many countries; however, there is no systematic comparison of thes...

journal_title：Epilepsia

authors： Alvarez V,Lee JW,Drislane FW,Westover MB,Novy J,Dworetzky BA,Rossetti AO

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Pathogenic variants of KCNQ2, which encode a potassium channel subunit, cause either benign (familial) neonatal epilepsy-B(F)NE)-or KCNQ2 encephalopathy (KCNQ2 DEE). We examined the characteristics of KCNQ2 variants. METHODS:KCNQ2 pathogenic variants were collected from in-house data and two large disease da...

journal_title：Epilepsia

authors： Goto A,Ishii A,Shibata M,Ihara Y,Cooper EC,Hirose S

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Generalized convulsive status epilepticus (GCSE) needs immediate management. Despite guidelines, adherence to management protocols is often poor, this contributing to poor outcome. We aimed to evaluate the usefulness of a management protocol in GCSE. METHODS:This is a prospective population-based study of cons...

journal_title：Epilepsia

authors： Aranda A,Foucart G,Ducassé JL,Grolleau S,McGonigal A,Valton L

更新日期：2010-10-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：:Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...

journal_title：Epilepsia

authors： Mitra J,Snider RS

更新日期：1975-06-01 00:00:00

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00

abstract：:The awareness, understanding, and attitudes toward epilepsy in 1,278 men and women were surveyed in Henan, China in 1988. Results showed that 93% had read or heard about epilepsy; 77% knew someone who had epilepsy; 72% had seen someone who was having a seizure; 57% would object to having their children associate with ...

journal_title：Epilepsia

authors： Lai CW,Huang XS,Lai YH,Zhang ZQ,Liu GJ,Yang MZ

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Despite national guidelines supporting surgical referral in drug-resistant epilepsy, it is hypothesized that surgery is underutilized. We investigated the volumes of lobectomy/amygdalohippocampectomy surgeries over time and examined differences in outcomes between (1) high-volume (HV), middle-volume (MV), and...

journal_title：Epilepsia

authors： Kwon CS,Blank L,Mu L,Jetté N

更新日期：2020-10-01 00:00:00

abstract：:The routine EEG study may prove inadequate in selected patients with recurrent and unprovoked seizures. Video-EEG monitoring is an important diagnostic innovation that may be used to confirm the diagnosis of a seizure disorder and classify seizure type. The methodologies and clinical applications of video-EEG monitori...

journal_title：Epilepsia

authors： Cascino GD

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (...

journal_title：Epilepsia

authors： Foldvary-Schaefer N,De Leon Sanchez I,Karafa M,Mascha E,Dinner D,Morris HH

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...

journal_title：Epilepsia

authors： Narayanan JT,Murthy JM

更新日期：2007-05-01 00:00:00

abstract：:We evaluated clinical indicators of genetic susceptibility to epilepsy in the families of 1,957 adults with epilepsy (probands) ascertained from voluntary organizations. Very few of the probands in this series had idiopathic epilepsy syndromes. Among relatives of probands with postnatal CNS insults, risks of epilepsy ...

journal_title：Epilepsia

authors： Ottman R,Lee JH,Risch N,Hauser WA,Susser M

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:Structural variations disrupting the gene encoding the neuron-specific splicing regulator RBFOX1 have been reported in three patients exhibiting epilepsy in comorbidity with other neuropsychiatric disorders. Consistently, the Rbfox1 knockout mouse model showed an increased susceptibility of seizures. The presen...

journal_title：Epilepsia

authors： Lal D,Trucks H,Møller RS,Hjalgrim H,Koeleman BP,de Kovel CG,Visscher F,Weber YG,Lerche H,Becker F,Schankin CJ,Neubauer BA,Surges R,Kunz WS,Zimprich F,Franke A,Illig T,Ried JS,Leu C,Nürnberg P,Sander T,EMINet Con

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To evaluate safety and tolerability of ketogenic diet (KGD) and valproate (VPA) cotherapy in the treatment of intractable seizures. METHODS:The patient records of children who underwent KGD initiation at the Massachusetts General Hospital for Children from February 2002 to September 2004 were retrospectively a...

journal_title：Epilepsia

authors： Lyczkowski DA,Pfeifer HH,Ghosh S,Thiele EA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To determine the lateralizing value of the clinical manifestations of seizures in patients with temporal lobe epilepsy (TLE), we made a retrospective videotape analysis of complex partial seizures (CPS) in 55 patients who underwent temporal lobectomy and were seizure-free postoperatively for >2 years. METHODS:...

journal_title：Epilepsia

authors： Marks WJ Jr,Laxer KD

更新日期：1998-07-01 00:00:00

abstract：:Clobazam was compared with placebo as antiepileptic adjunct medication in 129 therapy-resistant epileptic patients who were mainly suffering from complex partial seizures. The study was performed in five European countries according to a double-blind crossover design lasting 7 months. Two treatment periods of 3 months...

journal_title：Epilepsia

authors： Koeppen D,Baruzzi A,Capozza M,Chauvel P,Courjon J,Favel P,Harmant J,Lorenz H,Oller FV,Procaccianti G

更新日期：1987-09-01 00:00:00

abstract：:Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...

journal_title：Epilepsia

authors： Perucca E

更新日期：2001-01-01 00:00:00

abstract：:Brain magnetic resonance imaging (MRI) was studied in patients with mild-to-moderate temporal lobe epilepsy (TLE), well controlled by pharmacotherapy, and with normal computed tomographic (CT) scans. Magnetic resonance imaging abnormalities were found in 19 patients; of these, nine had abnormalities in temporomesial r...

journal_title：Epilepsia

authors： Franceschi M,Triulzi F,Ferini-Strambi L,Giusti MC,Minicucci F,Fazio F,Smirne S,Del Maschio A

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:Vagus nerve stimulation (VNS) is reported to reduce the frequency of seizures in children and adults without causing serious side effects. However, clinical observation of swallowing difficulties in 2 children treated with VNS made further investigation necessary. METHODS:Seven patients aged 4-18 years and tre...

journal_title：Epilepsia

authors： Lundgren J,Ekberg O,Olsson R

更新日期：1998-09-01 00:00:00

abstract：:The efficacy and the potential risk of inducing convulsive or nonconvulsive status epilepticus with the combination of valproate (VPA) and clonazepam (CZP), with or without other anticonvulsant drugs, in 55 patients with intractable epilepsy was evaluated. The patients were treated with VPA and CZP concomitantly for f...

journal_title：Epilepsia

authors： Mireles R,Leppik IE

更新日期：1985-03-01 00:00:00

abstract：PURPOSE:Lennox-Gastaut syndrome (LGS) is a severe epileptic condition characterized by multiple seizure types including tonic seizures, slow spike-and-wave discharges on electroencephalography (EEG), and cognitive impairment. LGS can occur in apparently healthy subjects or in patients with preexisting brain damage. The...

journal_title：Epilepsia

authors： Ferlazzo E,Adjien CK,Guerrini R,Calarese T,Crespel A,Elia M,Striano P,Gelisse P,Bramanti P,di Bella P,Genton P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation ...

journal_title：Epilepsia

authors： Szaflarski JP,Hughes C,Szaflarski M,Ficker DM,Cahill WT,Li M,Privitera MD

更新日期：2003-02-01 00:00:00

abstract：:The Epilepsy Association of Maryland, an affiliate of the Epilepsy Foundation of America (EFA), recognized that the Maryland state regulations and laws on driving licensing restricted the rights of individuals with epilepsy. After identifying the problem, the Association determined the needed changes and planned a leg...

journal_title：Epilepsia

authors： Kingham LA

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To determine the prevalence of epilepsy and seizures in the Navajo. METHODS:We studied 226,496 Navajo residing in the Navajo Reservation who had at least one medical encounter between October 1, 1998 and September 30, 2002. We ascertained and confirmed cases in two phases. First, we identified patients with In...

journal_title：Epilepsia

authors： Parko K,Thurman DJ

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Epilepsy is characterized by transient alterations in brain synchronization resulting in seizures with a wide spectrum of manifestations. Seizure severity and risks for patients depend on the evolution and spread of the hypersynchronous discharges. With standard visual inspection and pattern classification, t...

journal_title：Epilepsia

authors： Donos C,Maliia MD,Dümpelmann M,Schulze-Bonhage A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Identifying adverse outcomes and examining trends and causes of nonelective admissions among persons with epilepsy would be beneficial to optimize patient care and reduce health services utilization. We examined the association of epilepsy with discharge status, in-hospital mortality, length-of-stay, and char...

journal_title：Epilepsia

authors： Kwon CS,Wong B,Agarwal P,Lin JY,Mazumdar M,Dhamoon M,Jetté N

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To describe the behavioral and EEG topographic correlates of absences with 3-Hz generalized spike-waves and partitioned impairment of consciousness. METHODS:Two adult women had so-called "phantom" absences, characterized by brief and mild impairments of consciousness that were previously inconspicuous to both ...

journal_title：Epilepsia

authors： Vuilleumier P,Assal F,Blanke O,Jallon P

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To demonstrate the application of Disability Adjusted Life Year (DALY) as an aid in health outcome measures to evaluate the epilepsy disease burden in rural China and to provide Chinese data to achieve a better understanding of disease burden due to epilepsy. METHODS:The DALY is the sum of the number of years ...

journal_title：Epilepsia

authors： Ding D,Hong Z,Wang WZ,Wu JZ,de Boer HM,Prilipko L,Sander JW

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Previous studies have estimated medical care costs of epilepsy by applying unit costs to estimated utilization or by summing costs for (a) ambulatory care and hospitalizations coded as epilepsy and (b) procedures and drugs specifically associated with the diagnosis or treatment of epilepsy. These methods may un...

journal_title：Epilepsia

authors： Frost FJ,Hurley JS,Petersen HV,Gunter MJ,Gause D

更新日期：2000-08-01 00:00:00