Muscarinic receptor loss and preservation of presynaptic cholinergic terminals in hippocampal sclerosis.

abstract：:From the earliest days of neurology, the classification of epileptic seizures into those generalized from the beginning and those with a definable localization in the cortex from the onset has added to knowledge about the function of the nervous system. Further elaboration of the classification of seizures into those ...

journal_title：Epilepsia

authors： Dreifuss FE

更新日期：1990-01-01 00:00:00

abstract：:This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...

journal_title：Epilepsia

authors： Kovac S,Rodionov R,Chinnasami S,Wehner T,Scott CA,McEvoy AW,Miserocchi A,Diehl B

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

journal_title：Epilepsia

authors： Awad A,Sarkhoo F

更新日期：2008-04-01 00:00:00

abstract：:Children with epilepsy often grow into adults with significant social problems including decreased employment, marriage, social relationships, and independent living arrangements. These problems are noted in population-based longitudinal and cross-sectional studies from many countries. Learning disorder and mental han...

journal_title：Epilepsia

authors： Camfield CS,Camfield PR

更新日期：2007-01-01 00:00:00

abstract：:The duration of epilepsy was evaluated in over 460 previously untreated patients who attended newly established epilepsy clinics in a rural area of Malawi. The mean duration at first attendance was 6.5 years. It was found that as the duration of active epilepsy increased, the number of patients having epilepsy of a gi...

journal_title：Epilepsia

authors： Watts AE

更新日期：1992-05-01 00:00:00

abstract：:Over 100 years ago, on the 27th of January 1881, Fyodor Mikhailovitch Dostoevsky died. Since that time, many biographies, monographs, memoirs, and, to a lesser extent, articles in the medical literature have discussed the fact that Dostoevsky was a patient with epilepsy. An attempt is made here to integrate the detail...

journal_title：Epilepsia

authors： Voskuil PH

更新日期：1983-12-01 00:00:00

abstract：:An 8-year-old Chinese girl had a first episode of symptomatic partial epilepsy at age 2 years. Despite regular treatment with antiepileptic drugs (AEDs), the seizures remitted and exacerbated. Epileptiform EEG discharges were evident, arising from the left centroparietal region. Magnetic resonance imaging (MRI) and co...

journal_title：Epilepsia

authors： Wang PJ,Liu HM,Young C,Lin MY,Shen YZ

更新日期：1994-11-01 00:00:00

abstract：:A 10-year-old boy developed febrile convulsions at age 2 years, and multiple types of nonfebrile generalized seizures over the ensuing months and years. Gestation, birth, and early development were normal, as were initial EEG and brain imaging studies. By age 5 years, he had developed behavioral difficulties, and the ...

journal_title：Epilepsia

authors： Grant AC,Vazquez B

更新日期：2005-01-01 00:00:00

abstract：:Surgical techniques may vary extensively between centers. We report on a web-based survey aimed at evaluating the current technical approaches in different centers around the world performing epilepsy surgery in children. The intention of the survey was to establish technical standards. A request was made to 88 center...

journal_title：Epilepsia

authors： Cukiert A,Rydenhag B,Harkness W,Cross JH,Gaillard WD,Task Force for Pediatric Epilepsy Surgery for the ILAE Commissions of Pediatrics and Surgical Therapies.

更新日期：2016-02-01 00:00:00

abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...

journal_title：Epilepsia

authors： Zifkin BG,Avanzini G

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Lowering the length of stay (LOS) is thought to potentially decrease hospital costs and is a metric commonly used to manage capacity. Patients with epilepsy undergoing intracranial electrode monitoring may have longer LOS because the time to seizure is difficult to predict or control. This study investigates ...

journal_title：Epilepsia

authors： Chan AY,Kharrat S,Lundeen K,Mnatsakanyan L,Sazgar M,Sen-Gupta I,Lin JJ,Hsu FPK,Vadera S

更新日期：2017-06-01 00:00:00

abstract：:Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...

journal_title：Epilepsia

authors： Faught E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The concordance of lateralized EEG postictal polymorphic delta activity (PPDA) to the side of seizure origin in temporal lobe epilepsy (TLE) has received limited study. Our objective was to study the lateralizing value of PPDA in patients with documented TLE. METHODS:A cohort of consecutive adults with TLE, de...

journal_title：Epilepsia

authors： Jan MM,Sadler M,Rahey SR

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effe...

journal_title：Epilepsia

authors： Kahriman M,Minecan D,Kutluay E,Selwa L,Beydoun A

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Studies using magnetic resonance imaging have shown that reduced hippocampal volume is associated with a history of febrile seizures, the duration of epilepsy, and the number of generalized tonic-clonic seizures. It is uncertain whether these factors have the same influence on functional as on structural measur...

journal_title：Epilepsia

authors： Theodore WH,Kelley K,Toczek MT,Gaillard WD

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:In vitro brain preparations have been used extensively to study the generation and propagation of epileptiform activity. Transverse and longitudinal slices of the rodent hippocampus have revealed various patterns of propagation. Yet intact connections between the transverse and longitudinal pathways should gene...

journal_title：Epilepsia

authors： Kibler AB,Durand DM

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：:The effects of antiepileptic drugs (AEDs) on cognitive function and behavior in children are reviewed on the basis of published studies. Individual AEDs have been shown to differ--the deleterious effects of phenytoin generally contrasting with the relatively minimal effects of valproate and carbamazepine. Some of the ...

journal_title：Epilepsia

authors： Trimble MR

更新日期：1990-01-01 00:00:00

abstract：:To improve the diagnostic accuracy of electroencephalography (EEG) criteria for nonconvulsive status epilepticus (NCSE), external validation of the recently proposed Salzburg criteria is paramount. We performed an external, retrospective, diagnostic accuracy study of the Salzburg criteria, using EEG recordings from pa...

journal_title：Epilepsia

authors： Goselink RJM,van Dillen JJ,Aerts M,Arends J,van Asch C,van der Linden I,Pasman J,Saris CGJ,Zwarts M,van Alfen N

更新日期：2019-08-01 00:00:00

abstract：:The effects of 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) and phenobarbital (PB) on synaptic excitation and inhibition in rat hippocampal slices in vitro were compared. Stimulations were made orthodromically and antidromically while we recorded extracellularly from the dendritic and the somatic layer of the CA...

journal_title：Epilepsia

authors： Taubøll E,Gjerstad L

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To report our evaluation of interictal two epileptic spike fields on magnetoencephalography (MEG) by using invasive intracranial monitoring in a patient without lesion on magnetic resonance imaging (MRI). METHODS:A 15-year-old left-handed boy with a 9-year history of refractory simple partial seizures, seconda...

journal_title：Epilepsia

authors： Otsubo H,Sharma R,Elliott I,Holowka S,Rutka JT,Snead OC 3rd

更新日期：1999-05-01 00:00:00

abstract：:Small animal magnetic resonance imaging (MRI) has opened a window through which brain abnormalities can be observed over time in rodents noninvasively. We review MRI studies done during epileptogenesis triggered by status epilepticus in rat. Most of these studies have used quantitative T2, diffusion, and/or volumetric...

journal_title：Epilepsia

authors： Gröhn O,Pitkänen A

更新日期：2007-01-01 00:00:00

abstract：:Cognitive impairment is the most common comorbidity in children with epilepsy, but its pathophysiology and predisposing conditions remain unknown. Clinical epilepsy characteristics are not conclusive in determining cognitive outcome. Because many children with epilepsy do not have macrostructural magnetic resonance im...

journal_title：Epilepsia

authors： Braakman HM,van der Kruijs SJ,Vaessen MJ,Jansen JF,Debeij-van Hall MH,Vles JS,Aldenkamp AP,Backes WH,Hofman PA

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Subtle microdysplastic features are found in some patients with hippocampal sclerosis (HS) and refractory temporal lobe epilepsy. The significance of these findings is unknown. We investigated their frequency, relation to the pattern of HS, and clinical associations. METHODS:One-hundred forty patients with his...

journal_title：Epilepsia

authors： Kalnins RM,McIntosh A,Saling MM,Berkovic SF,Jackson GD,Briellmann RS

更新日期：2004-08-01 00:00:00

abstract：:Amygdala kindling is used to investigate cerebellar dentate nucleus participation in the neuronal plasticity of the cerebrum. We studied the behavioral change, the occurrence of epileptiform events, and the duration of afterdischarge during amygdaloid kindling under control conditions and after a dentate lesion of the...

journal_title：Epilepsia

authors： Tsuru N,Kawasaki H,Genda S,Hara K,Hashiguchi H,Ueda Y

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:Eyelid myoclonic jerks have been described in fixation-off-sensitive (FOS) epilepsy, but their relationship to nonconvulsive status epilepticus (NCSE) or to catamenial exacerbations is little reported. METHODS:We describe a woman of normal intelligence with catamenial periods of prolonged NCSE who exhibited va...

journal_title：Epilepsia

authors： Ming X,Kaplan PW

更新日期：1998-06-01 00:00:00

abstract：:Although the technical and human resources for epilepsy care and classification are located largely in high income countries, most people with epilepsy reside in developing regions of the world. Advances over the past two decades in the clinical and basic neurosciences have transformed epilepsy care and largely drive ...

journal_title：Epilepsia

authors： Birbeck GL

更新日期：2012-07-01 00:00:00

abstract：:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...

journal_title：Epilepsia

authors： Mareš P,Kubová H

更新日期：2015-01-01 00:00:00

abstract：:The possibility of sudden unexpected death in epilepsy (SUDEP) should affect the management of virtually every patient with proven or suspected epilepsy by (a) underlining the need to make all reasonable efforts to render each patient seizure-free; (b) emphasizing the importance of minimizing avoidable seizures; (c) b...

journal_title：Epilepsia

authors： Fish DR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures. It is known that metabolic crises in affected patients are precipitated by infections. Although growing evidence supports that inflammation facilitates sei...

journal_title：Epilepsia

authors： Salvadori MG,Banderó CR,Jesse AC,Gomes AT,Rambo LM,Bueno LM,Bortoluzzi VT,Oliveira MS,Mello CF

更新日期：2012-01-01 00:00:00