Abstract:
PURPOSE:Studies using magnetic resonance imaging have shown that reduced hippocampal volume is associated with a history of febrile seizures, the duration of epilepsy, and the number of generalized tonic-clonic seizures. It is uncertain whether these factors have the same influence on functional as on structural measures of the integrity of the epileptogenic zone. METHODS:We used positron emission tomography (PET) with fluorine 18 2-deoxyglucose to study 91 patients with temporal lobe seizure foci localized by ictal video-EEG. PET was performed in the awake interictal resting state with ears plugged and eyes patched. We recorded surface EEG during injection (5 mCi) and the 30-min uptake period. We used a standard template to analyze PET scans. RESULTS:A significant negative relation was found between the duration of epilepsy and hippocampal glucose metabolism ipsilateral to the epileptic focus. Patients with a history of either any febrile seizures, or complex, or prolonged febrile seizures, did not have greater hypometabolism ipsilateral to the epileptic focus than did patients without a febrile seizure history. We found no effect of generalized tonic-clonic seizure history. CONCLUSIONS:Longer epilepsy duration is associated with greater hypometabolism, suggesting that epilepsy is a progressive disease.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Theodore WH,Kelley K,Toczek MT,Gaillard WDdoi
10.1111/j.0013-9580.2004.51803.xsubject
Has Abstractpub_date
2004-03-01 00:00:00pages
276-9issue
3eissn
0013-9580issn
1528-1167journal_volume
45pub_type
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