A case of extended spectrum GEFS+.

abstract：:The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

journal_title：Epilepsia

authors： Offermann G,Pinto V,Kruse R

更新日期：1979-02-01 00:00:00

abstract：PURPOSE:With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mg/kg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder. METHODS:Experiments were performed in 12-, 18-, and 60-day...

journal_title：Epilepsia

authors： Kábová R,Liptáková S,Slamberová R,Pometlová M,Velísek L

更新日期：1999-10-01 00:00:00

abstract：:The purpose of the study was to examine the impact of idiopathic epilepsy on mothers and fathers in terms of strain, burden of care, worries and perception of vulnerability. Data were collected and analyzed shortly after the diagnosis (T0) and 12 months later (T1). The results indicated that at T0 parents of children ...

journal_title：Epilepsia

authors： Ramaglia G,Romeo A,Viri M,Lodi M,Sacchi S,Cioffi G

更新日期：2007-09-01 00:00:00

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...

journal_title：Epilepsia

authors： Ristić AJ,Savić D,Sokić D,Bogdanović Pristov J,Nestorov J,Baščarević V,Raičević S,Savić S,Spasojević I

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...

journal_title：Epilepsia

authors： Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

更新日期：2002-09-01 00:00:00

abstract：:Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated anim...

journal_title：Epilepsia

authors： Diehl RG,Smialowski A,Gotwo T

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:The aim of this article is to review the literature on the effects of psychostimulants in epileptic subjects in order to reach a consensus statement regarding the use or abuse of these substances. METHODS:Psychostimulant substances have been considered the drugs that share the ability to produce excitation of ...

journal_title：Epilepsia

authors： Zagnoni PG,Albano C

更新日期：2002-01-01 00:00:00

abstract：:The presence of the excitotoxic and convulsant agent quinolinic acid (QUIN) in human brain has led to the hypothesis that an increase of this tryptophan metabolite could serve as an endogenous epileptogen. A possible mechanism for a pathological accumulation of QUIN being a deficiency in its degradation, we have measu...

journal_title：Epilepsia

authors： Feldblum S,Rougier A,Loiseau H,Loiseau P,Cohadon F,Morselli PL,Lloyd KG

更新日期：1988-09-01 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of multiple subpial transection (MST), a new technique in epilepsy surgery, alone and in combination with resection. METHODS:MST was performed in 22 patients with intractable epilepsy, 10 of whom were treated with a combination of a resection and MST in functionally important ...

journal_title：Epilepsia

authors： Hufnagel A,Zentner J,Fernandez G,Wolf HK,Schramm J,Elger CE

更新日期：1997-06-01 00:00:00

abstract：:There is little evidence to guide the choice of intravenous anesthetic agent to treat refractory status epilepticus but midazolam, propofol, and barbiturates are widely used. It is impractical to use inhalational anesthetic agents in most circumstances and there is little experience with non-GABA-ergic agents such as ...

journal_title：Epilepsia

authors： Smith M

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Lennox-Gastaut syndrome (LGS) is a severe epileptic condition characterized by multiple seizure types including tonic seizures, slow spike-and-wave discharges on electroencephalography (EEG), and cognitive impairment. LGS can occur in apparently healthy subjects or in patients with preexisting brain damage. The...

journal_title：Epilepsia

authors： Ferlazzo E,Adjien CK,Guerrini R,Calarese T,Crespel A,Elia M,Striano P,Gelisse P,Bramanti P,di Bella P,Genton P

更新日期：2009-06-01 00:00:00

abstract：:Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed before 1980 appear to act on sodium channels, gamma-aminobutyric acid type A (GABAA) receptors, or calcium channels. Benzodiazepines and barbiturates enhance GABAA recept...

journal_title：Epilepsia

authors： Macdonald RL,Kelly KM

更新日期：1995-01-01 00:00:00

abstract：:Fibroblast growth-factor homologous factor (FHF1) gene variants have recently been associated with developmental and epileptic encephalopathy (DEE). FHF1 encodes a cytosolic protein that modulates neuronal sodium channel gating. We aim to refine the electroclinical phenotypic spectrum of patients with pathogenic FHF1 ...

journal_title：Epilepsia

authors： Trivisano M,Ferretti A,Bebin E,Huh L,Lesca G,Siekierska A,Takeguchi R,Carneiro M,De Palma L,Guella I,Haginoya K,Shi RM,Kikuchi A,Kobayashi T,Jung J,Lagae L,Milh M,Mathieu ML,Minassian BA,Novelli A,Pietrafusa N,T

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00

abstract：:The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced ...

journal_title：Epilepsia

authors： Trimble M

更新日期：1978-06-01 00:00:00

abstract：OBJECTIVE:Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood. METHODS:In the present study, we determined the effects of eslicarbazepine (S-Lic) on diff...

journal_title：Epilepsia

authors： Schmidt S,Pothmann L,Müller-Komorowska D,Opitz T,Soares da Silva P,Beck H

更新日期：2021-01-16 00:00:00

abstract：:The clinical presentation of 366 children with rolandic spikes was examined to determine whether the presence of a temporal-frontal dipole field is associated with a lower incidence of clinical abnormality. Comparisons were made between the clinical presentation of 99 children with temporal-frontal dipole discharges v...

journal_title：Epilepsia

authors： Gregory DL,Wong PK

更新日期：1992-01-01 00:00:00

abstract：:This article explores the historic underpinnings of the exclusion of women from clinical drug trials, identifies recent developments, and examines legal implications for women with epilepsy and for others. Distinguishing stakeholders and their interests may lead to policies that better serve all. Past and present stat...

journal_title：Epilepsia

authors： Herz SE

更新日期：1997-01-01 00:00:00

abstract：:West syndrome consists of infantile spasms, hypsarrhythmia, and developmental arrest. Most patients remain mentally retarded and many develop Lennox-Gastaut syndrome. Using homozygosity mapping followed by exome sequencing we identified an ST3GAL3 mutation in three infants with West syndrome. ST3GAL3 encodes a sialylt...

journal_title：Epilepsia

authors： Edvardson S,Baumann AM,Mühlenhoff M,Stephan O,Kuss AW,Shaag A,He L,Zenvirt S,Tanzi R,Gerardy-Schahn R,Elpeleg O

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. METHODS:In acute studies of anticonvulsant efficacy, the AEDs were administered via or...

journal_title：Epilepsia

authors： White HS,Franklin MR,Kupferberg HJ,Schmutz M,Stables JP,Wolf HH

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To describe the natural history of electroencephalography (EEG) changes in patients with benign epilepsy with centrotemporal spikes (BECTS) over 1 year. METHODS:Centrotemporal spikes were visually evaluated based on 24-h ambulatory EEG studies to determine the total, left, right, and bilateral centrotemporal...

journal_title：Epilepsia

authors： Tenney JR,Glauser T,Altaye M,Szaflarski JP,Spencer C,Morita D,Vannest J

更新日期：2016-05-01 00:00:00

abstract：:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which ...

journal_title：Epilepsia

authors： Francis PT,Lowe SL,Bowen DM,Jefferys JG

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:We analyzed sequential changes in the localization of EEG foci along with age to identify a specific EEG pattern, and the relation between the clinical manifestations and the EEG pattern in patients with Panayiotopoulos syndrome (PS). METHODS:The subjects were 76 children, who had been followed up >2 years wit...

journal_title：Epilepsia

authors： Ohtsu M,Oguni H,Hayashi K,Funatsuka M,Imai K,Osawa M

更新日期：2003-03-01 00:00:00

abstract：:Circling seizures (CS) have been described in association with focal lesions as well as with generalized EEG discharges. We report 1 patient with juvenile myoclonic epilepsy (JME) who developed CS. There were no focal findings on clinical examination, EEG, or imaging studies. We propose that CS in this patient may rep...

journal_title：Epilepsia

authors： Lancman ME,Asconapé JJ,Golimstok A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To investigate further the membrane properties and postsynaptic potentials of the CA3 pyramidal cells in mice that display spontaneous seizures because of a targeted deletion of the Kcna1 potassium channel gene (encoding the Kv1.1 protein subunit). METHODS:Intracellular recordings were obtained from CA3 pyrami...

journal_title：Epilepsia

authors： Lopantsev V,Tempel BL,Schwartzkroin PA

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:A drug holiday seems to produce seizure interval prolongation (SIP) after reinstitution of antiepileptic drugs (AEDs). This effect was demonstrated mainly with carbamazepine. We evaluated SIP with newer AEDs and tested the relationship of SIP to history of AED tolerance. METHODS:We prospectively studied patien...

journal_title：Epilepsia

authors： Azar NJ,Lagrange AH,Wang L,Song Y,Abou-Khalil BW

更新日期：2010-05-01 00:00:00

abstract：:The practice of epileptology at a molecular level, where gene products are identified by gene mapping, will soon be possible for a growing number of epilepsies. Juvenile myoclonic epilepsy (JME) is the first of such epilepsies to be mapped to a chromosome, namely chromosome 6p21.3. Family studies of 68 JME probands fr...

journal_title：Epilepsia

authors： Delgado-Escueta AV,Greenberg DA,Treiman L,Liu A,Sparkes RS,Barbetti A,Park MS,Terasaki PI

更新日期：1989-01-01 00:00:00

abstract：:Acute administration of taurine produced a transient loss of susceptibility to photically induced seizures in photosensitive baboons, but failed to affect kindled amygdaloid convulsions in baboons, rats, and cats. In addition, it was totally ineffective in changing the course of spontaneous status epilepticus in kindl...

journal_title：Epilepsia

authors： Wada JA,Osawa T,Wake A,Corcoran ME

更新日期：1975-06-01 00:00:00

abstract：OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

journal_title：Epilepsia

authors： Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

更新日期：2020-09-01 00:00:00