Pharmacokinetic considerations in prescribing antiepileptic drugs.

abstract：PURPOSE:To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. METHODS:A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical I...

journal_title：Epilepsia

authors： Mady MA,Kossoff EH,McGregor AL,Wheless JW,Pyzik PL,Freeman JM

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:New continuous infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE. This systematic review compares the efficacy of midazolam (MDL), propofol (PRO),...

journal_title：Epilepsia

authors： Claassen J,Hirsch LJ,Emerson RG,Mayer SA

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:To study cortical excitability after status epilepticus induced in two age groups of immature rats. METHODS:Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats. Control siblings received saline instead of pilocarpine. Interhemispheric responses were elicited by stimulati...

journal_title：Epilepsia

authors： Mares P,Tsenov G,Aleksakhina K,Druga R,Kubová H

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...

journal_title：Epilepsia

authors： de Almeida AC,Rodrigues AM,Scorza FA,Cavalheiro EA,Teixeira HZ,Duarte MA,Silveira GA,Arruda EZ

更新日期：2008-11-01 00:00:00

abstract：:A multicenter prospective study was initiated at the time of first antiepileptic treatment for afebrile seizures with 283 unselected patients in Italy. Each patient started with monotherapy at standard daily doses. Data were collected at admission, at scheduled 6-month exams, and at unscheduled exams and included age,...

journal_title：Epilepsia

authors： Beghi E,Tognoni G

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. ...

journal_title：Epilepsia

authors： Reid AY,Bragin A,Giza CC,Staba RJ,Engel J Jr

更新日期：2016-10-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：:Management of epilepsy in the elderly requires understanding of the unique biochemical and pharmacologic characteristics of this patient population. Accurate assessment of seizures and identification of epilepsy syndromes, thorough neurologic assessment to define etiology, and comprehensive evaluation of the patient's...

journal_title：Epilepsia

authors： Willmore LJ

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...

journal_title：Epilepsia

authors： Strzelczyk A,Cenusa M,Bauer S,Hamer HM,Mothersill IW,Grunwald T,Hillenbrand B,Ebner A,Steinhoff BJ,Krämer G,Rosenow F

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. METHODS:We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analys...

journal_title：Epilepsia

authors： Loesch AM,Steger H,Losher C,Hartl E,Rémi J,Vollmar C,Noachtar S

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients. METHODS:Logistic regression analyses were used to determine the rel...

journal_title：Epilepsia

authors： Baxendale S,Thompson P,Harkness W,Duncan J

更新日期：2007-03-01 00:00:00

abstract：:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...

journal_title：Epilepsia

authors： Mareš P,Kubová H

更新日期：2015-01-01 00:00:00

abstract：:Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...

journal_title：Epilepsia

authors： Gilby KL,Crino P,McIntyre DC

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To identify the brain networks that are involved in the different electroencephalography (EEG) abnormalities in patients with ring chromosome 20 [r(20)] syndrome. We hypothesize the existence of both distinctive and common brain circuits for the paroxysmal high voltage sharp waves (hSWs), the seizures, and th...

journal_title：Epilepsia

authors： Vaudano AE,Ruggieri A,Vignoli A,Avanzini P,Benuzzi F,Gessaroli G,Nichelli PF,Darra F,Cantalupo G,Mastrangelo M,Dalla Bernardina B,Canevini MP,Meletti S

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is more common in children than adults and has a high mortality and morbidity rate. SE in adult rats results in long-term disturbances in learning and memory, as well as an enhanced seizure susceptibility to further seizures. In contrast, a number of studies suggest that the immature bra...

journal_title：Epilepsia

authors： Cilio MR,Sogawa Y,Cha BH,Liu X,Huang LT,Holmes GL

更新日期：2003-04-01 00:00:00

abstract：:The routine EEG study may prove inadequate in selected patients with recurrent and unprovoked seizures. Video-EEG monitoring is an important diagnostic innovation that may be used to confirm the diagnosis of a seizure disorder and classify seizure type. The methodologies and clinical applications of video-EEG monitori...

journal_title：Epilepsia

authors： Cascino GD

更新日期：2002-01-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rCRF) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. Such an effect was still present in rats neonatally treated with saline but was absent in...

journal_title：Epilepsia

authors： Marrosu F,Argiolas A,Carcangiu P,Giagheddu M,Fratta W

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To develop an epilepsy-specific comorbidity risk adjustment index for mortality outcomes research. METHODS:Data were extracted from five linked administrative databases in Calgary, Canada from April 1, 1996 to March 31, 2004. Epilepsy patients were defined using a validated ICD-9-CM- and ICD-10-CA-based case d...

journal_title：Epilepsia

authors： St Germaine-Smith C,Liu M,Quan H,Wiebe S,Jette N

更新日期：2011-12-01 00:00:00

abstract：:Sleep is a modulator of seizure activity, and many antiepileptic drugs are modulators of sleep. Can influences on sleep organization be involved in antiepileptic drug action, and can these partly account for differences in drug response of various epileptic syndromes? Much more exact data must be collected before thes...

journal_title：Epilepsia

authors： Wolf P,Röder-Wanner UU,Brede M

更新日期：1984-08-01 00:00:00

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：:Ketogenic diets (KDs) are effective treatments for epilepsy. The mechanisms of action are poorly understood. In some experimental seizure models, calorie restriction and hypoglycemia may augment the antiseizure effects of KDs. In addition, inhibiting glycolysis or diverting glucose from the glycolytic pathway inhibits...

journal_title：Epilepsia

authors： Yamada KA

更新日期：2008-11-01 00:00:00

abstract：:Standard antiepileptic drugs (AEDs) are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management. The safety and interaction profiles of the newer AEDs have also been intensively studied. Safety data are available...

journal_title：Epilepsia

authors： Shorvon S,Stefan H

更新日期：1997-01-01 00:00:00

abstract：:The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippo...

journal_title：Epilepsia

authors： Szot P

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...

journal_title：Epilepsia

authors： Mei D,Darra F,Barba C,Marini C,Fontana E,Chiti L,Parrini E,Dalla Bernardina B,Guerrini R

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

journal_title：Epilepsia

authors： Awad A,Sarkhoo F

更新日期：2008-04-01 00:00:00

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00

abstract：:Ideal antiepileptic drugs (AEDs) are designed to stop seizures with limited central nervous system (CNS) side effects. However, CNS-related treatment-emergent adverse events (TEAEs) often occur in patients receiving AEDs. Topiramate (TPM) is an AED proven to be safe and effective as adjunctive treatment for epilepsy p...

journal_title：Epilepsia

authors： Tatum WO 4th,French JA,Faught E,Morris GL 3rd,Liporace J,Kanner A,Goff SL,Winters L,Fix A,PADS Investigators. Post-marketing antiepileptic drug survey.

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). METHODS:We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investiga...

journal_title：Epilepsia

authors： Kobayashi E,D'Agostino MD,Lopes-Cendes I,Andermann E,Dubeau F,Guerreiro CA,Schenka AA,Queiroz LS,Olivier A,Cendes F,Andermann F

更新日期：2003-08-01 00:00:00

abstract：:In developed countries, the incidence of epilepsy is 50-100 cases per 100,000 population per year and the prevalence is approximately 5 to 8 cases per 1,000 population. Epilepsy is by far the most prevalent serious neurologic condition. Mortality rates in epilepsy are two to four times those found in matched nonepilep...

journal_title：Epilepsia

authors： Shorvon SD

更新日期：1996-01-01 00:00:00