Abstract：
:A multicenter prospective study was initiated at the time of first antiepileptic treatment for afebrile seizures with 283 unselected patients in Italy. Each patient started with monotherapy at standard daily doses. Data were collected at admission, at scheduled 6-month exams, and at unscheduled exams and included age, sex, general profile of the disease, and treatment. Prognosis of epilepsy was evaluated by actuarial methods using first seizure relapse after onset of treatment to indicate unfavorable prognosis. In addition, a maximum interval of complete seizure control was calculated and related to length of follow-up in order to grade the severity of the disease (defined as mild, moderate, or severe). The average length of follow-up was 21.6 months (range 2-40). Seizure relapse occurred in 52% of cases during follow-up (36% by 3 months, 43% by 6 months, and 49% by 12 months). A larger number of seizures before therapy and the presence of combined seizure patterns were the variables most commonly associated with relapse. In general, epilepsy was mild in 65% of the cases, moderate in 28%, and severe in 7%. The earlier the first relapse the higher the risk of developing more severe disease. A larger number of seizures before treatment, combined seizure types, earlier age at onset, and prolonged disease duration (1 month to 1 year) seemed to be more frequently associated with the development of moderate-to-severe epilepsy.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Beghi E,Tognoni Gdoi
10.1111/j.1528-1157.1988.tb03712.xsubject
Has Abstractpub_date
1988-05-01 00:00:00pages
236-43issue
3eissn
0013-9580issn
1528-1167journal_volume
29pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract：PURPOSE:To evaluate the effect of stress on seizure frequency in childhood epilepsy, and to assess possible differences between children in whom seizures are precipitated by stress and those in whom they are not. METHODS:Parents or caregivers of children with active epilepsy (aged 2-16 years) were sent questionnaires ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2012.03566.x
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2007.01099.x
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1046/j.1528-1157.2002.38601.x
更新日期：2002-08-01 00:00:00
abstract：:In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1996.tb00597.x
更新日期：1996-05-01 00:00:00
abstract：:The identification and correction of adverse physiological changes that lead to seizures in children can improve the effectiveness of current therapeutic practices in epilepsy. It is proposed that various circadian rhythms (respiration, hormones, water balance, electrolytes, intracranial pressure, blood pressure), met...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1980.tb04090.x
更新日期：1980-08-01 00:00:00
abstract：:Rare individuals suffer epileptic seizures when they view certain images, particularly stripes. Contrast-threshold functions (the ability to see faint stripes of various widths) were determined for two pattern-sensitive brothers, and the epileptogenicity of various patterns was assessed for one of them. Sine wave grat...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1980.tb04075.x
更新日期：1980-06-01 00:00:00
abstract：PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2008.01686.x
更新日期：2008-11-01 00:00:00
abstract：:Forty-five outpatients with chronic epilepsy with complex partial seizures (CPS) alone or associated with secondarily generalized tonic-clonic seizures (SGTCS) were treated with carbamazepine (CBZ) monotherapy. All patients had only a unilateral scalp electroencephalographic (EEG) focus. Left- (n = 29) and right- (n =...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1991.tb04713.x
更新日期：1991-09-01 00:00:00
abstract：PURPOSE:The adenosinergic system is known to exert an inhibitory affect in the brain, and as such adenosine has been considered an endogenous anticonvulsant. Entorhinal cortex (EC) layer II neurons, which serve as the primary input to the hippocampus, are spared in temporal lobe epilepsy (TLE) and become hyperexcitable...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2011.03337.x
更新日期：2012-01-01 00:00:00
abstract：:Magnetic resonance spectroscopy (MRS) can be used for noninvasive measurement of more than two dozen small metabolites in the brains of living animals and humans. In the first decade of its use for study of seizure phenomena in animals, MRS successfully detected in vivo seizure-induced cerebral acidosis and reduction ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1994.tb05984.x
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS:Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: p...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2011.03260.x
更新日期：2011-11-01 00:00:00
abstract：PURPOSE:We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS:We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic co...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2008.01780.x
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1046/j.1528-1157.2002.10702.x
更新日期：2002-11-01 00:00:00
abstract：:To evaluate the impact of epileptiform discharges (EDs) that do not occur within seizure patterns--such as spikes, sharp waves or spike waves--on cognitive function and to discuss the circumstances under which treatment of EDs might be considered. Methods used in this article is "Review of the literature". EDs may dis...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/epi.13108
更新日期：2015-10-01 00:00:00
abstract：:We report the clinical presentation, neuroradiologic characteristics, and detailed histopathologic findings in a unique case of drug-resistant focal epilepsy due to sublobar dysplasia (SLD), treated successfully by resection of the malformed cortex. Histopathology with leptomeningeal and subcortical heterotopia, distu...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2009.02326.x
更新日期：2009-12-01 00:00:00
abstract：:The relationship between diurnal fluctuations in free (unbound) and total plasma carbamazepine levels and the appearance of intermittent side effects was investigated in nine epileptic patients receiving chronic therapy with carbamazepine, alone or in combination with phenobarbital. On a three-times-daily or four-time...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1984.tb03446.x
更新日期：1984-08-01 00:00:00
abstract：:We evaluated language functions in 154 patients with left hemisphere speech dominance undergoing anterior temporal lobectomy (ATL). Measures of phonemic and semantic fluency, confrontation naming, repetition, comprehension, and reading were administered before and 3 weeks postoperatively. Patients were grouped by focu...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1995.tb00464.x
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2006.00418.x
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:To study the mechanisms of startle-induced supplementary sensorimotor area (SSMA) seizures. METHODS:We present a patient investigated with indwelling subdural grid electrodes covering both the SSMA and the dorsolateral frontal lobe. RESULTS:We found a simultaneous seizure onset in the right dorsolateral premo...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1999.tb00813.x
更新日期：1999-07-01 00:00:00
abstract：:We determined the incidence of seizures due to acute CNS insults for residents of Rochester, Minnesota, U.S.A., from 1935 through 1984. The age-adjusted incidence rates for 1955-1984, the period of most complete case ascertainment, was 39.0/100,000 person-years (United States 1970 population as standard). The age-adju...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1995.tb01005.x
更新日期：1995-04-01 00:00:00
abstract：:Two cases of discontinuous status epilepticus (SE) characterized by repetitive asymmetrical atonic episodes associated with diffuse but asymmetrical spike waves are reported. Both patients also had partial seizures and interictal rolandic discharges. Dynamic EEG topography was performed to investigate the location or ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1990.tb06103.x
更新日期：1990-09-01 00:00:00
abstract：PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2011.03267.x
更新日期：2011-12-01 00:00:00
abstract：:The medical treatment of seizure disorders is a complex process, requiring extensive interaction and co-operation between physician and patient. The physician must have an accurate diagnosis of the patient's illness and a comprehensive understanding of seizures and seizure disorders. The physician must consider specif...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/j.1528-1157.1995.tb05994.x
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2005.58404.x
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety, tolerability, and comparative pharmacokinetics (PK) of intravenous and oral carbamazepine. METHODS:In this phase 1, open-label study, adult patients with epilepsy on a stable oral carbamazepine dosage (400-2,000 mg/day) were converted to intravenous carbamazepine (administered at 70% ...
journal_title：Epilepsia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/epi.13012
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Epileptic seizures are associated with a dysregulation of electrical brain activity on many different spatial scales. To better understand the dynamics of epileptic seizures, that is, how the seizures initiate, propagate, and terminate, it is important to consider changes of electrical brain activity on differe...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2012.03588.x
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-19...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1999.tb00739.x
更新日期：1999-04-01 00:00:00
abstract：:The incidence of idiopathic/cryptogenic epilepsy and isolated unprovoked seizures has been relatively stable in the population of Rochester, Minnesota, for the 50-year period 1935 through 1984. In each decade, the age-specific rates exhibited a consistent U-shaped pattern of decreasing rates from infancy to age 40-49 ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1995.tb02570.x
更新日期：1995-06-01 00:00:00
abstract：:A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1994.tb02927.x
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:The pineal hormone melatonin has been shown to enhance hippocampal excitability. We therefore investigated whether inactivation of hippocampal melatonin receptors affects behavioral seizures. METHODS:Intrahippocampal infusions were performed in rats to study the effect of different melatonin receptor antagonis...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.0013-9580.2005.30204.x
更新日期：2005-04-01 00:00:00
