Stress sensitivity of childhood epilepsy is related to experienced negative life events.

abstract：OBJECTIVE:Sex differences are evident in the antiseizure activity of neurosteroids; however, the potential mechanisms remain unclear. In this study, we sought to determine whether differences in target extrasynaptic δ-subunit γ-aminobutyric acid type A (GABA-A) receptor expression and function underlie the sex differen...

journal_title：Epilepsia

authors： Reddy DS,Carver CM,Clossen B,Wu X

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Refractory status epilepticus (RSE) is the persistence of seizure activity despite appropriate therapy; it is treated with high-dose suppressive anesthetic agents. We report here the outcome of RSE in a large series of children. METHODS:We retrospectively reviewed cases of RSE treated at Children's Hospital, B...

journal_title：Epilepsia

authors： Sahin M,Menache CC,Holmes GL,Riviello JJ

更新日期：2001-11-01 00:00:00

abstract：:Our study investigated public attitudes toward epilepsy, and knowledge and understanding of epilepsy in Hungary. We compared changes of public attitudes in the last six years, hypothesizing a trend of positive changes because of recent national initiatives for acceptance and integration of people with epilepsy (e.g., ...

journal_title：Epilepsia

authors： Mirnics Z,Czikora G,Závecz T,Halász P

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...

journal_title：Epilepsia

authors： Mei D,Darra F,Barba C,Marini C,Fontana E,Chiti L,Parrini E,Dalla Bernardina B,Guerrini R

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The antiepileptic effects of clobazam, a 1,5-benzodiazepine, have been well documented in animal experiments and clinical trials. However, the drug's mechanisms of antiepileptic actions are still undetermined. The purpose of this study was to learn how clobazam and its active metabolite modulate gamma-aminobuty...

journal_title：Epilepsia

authors： Nakamura F,Suzuki S,Nishimura S,Yagi K,Seino M

更新日期：1996-08-01 00:00:00

abstract：:The development of the Neuropsychological Battery for Epilepsy is presented. The tests are designed to be helpful in the evaluation of adult epileptics. The battery consists of General Measures which include tests in the areas of intellectual functioning, emotional status, and lateral dominance. The development of a s...

journal_title：Epilepsia

authors： Dodrill CB

更新日期：1978-12-01 00:00:00

abstract：:The management of epilepsy is an essential clinical issue in many patients with brain tumors. Tumoral epilepsy is often drug resistant and is associated with poor quality of life. Surgery represents a key therapeutic option in the management of patients with refractory tumoral epilepsy, with high rates of postoperativ...

journal_title：Epilepsia

authors： Rheims S,Ducray F,Ryvlin P

更新日期：2013-12-01 00:00:00

abstract：:Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video-EEG recording of both spontaneous and suggestion-induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using sal...

journal_title：Epilepsia

authors： Bazil CW,Kothari M,Luciano D,Moroney J,Song S,Vasquez B,Weinreb HJ,Devinsky O

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:To evaluate the demographic impact of epilepsy a rural area of Africa. METHODS:A cohort study was conducted between 1991 and 2001 in the Mbam Valley (Cameroon) on two groups of subjects (one of persons with epilepsy, and the other of control individuals matched for sex, age, and village of residence). At the e...

journal_title：Epilepsia

authors： Kamgno J,Pion SD,Boussinesq M

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Very fast activity was investigated on the ictal EEGs of epileptic spasms to elucidate the pathophysiology of West syndrome (WS) and related disorders from a novel point of view. METHODS:The traces of scalp ictal EEG of spasms temporally were expanded in 11 patients whose clinical diagnosis was symptomatic WS ...

journal_title：Epilepsia

authors： Kobayashi K,Oka M,Akiyama T,Inoue T,Abiru K,Ogino T,Yoshinaga H,Ohtsuka Y,Oka E

更新日期：2004-05-01 00:00:00

abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...

journal_title：Epilepsia

authors： Jayakar P,Gotman J,Harvey AS,Palmini A,Tassi L,Schomer D,Dubeau F,Bartolomei F,Yu A,Kršek P,Velis D,Kahane P

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). METHODS:Clinical and radiographic data were reviewed from a prosp...

journal_title：Epilepsia

authors： Jermakowicz WJ,Kanner AM,Sur S,Bermudez C,D'Haese PF,Kolcun JPG,Cajigas I,Li R,Millan C,Ribot R,Serrano EA,Velez N,Lowe MR,Rey GJ,Jagid JR

更新日期：2017-05-01 00:00:00

abstract：:Epilepsy is a disease of complex etiology, and multiple molecular mechanisms contribute to its development. Temporal lobe epilepsy (TLE) may result from an initial precipitating event such as hypoxia, head injury, or prolonged seizure (i.e., status epilepticus [SE]), that is followed by a latent period of months to ye...

journal_title：Epilepsia

authors： Grabenstatter HL,Russek SJ,Brooks-Kayal AR

更新日期：2012-12-01 00:00:00

abstract：:Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...

journal_title：Epilepsia

authors： Kugoh T

更新日期：1996-01-01 00:00:00

abstract：:Posttraumatic epilepsy is a common complication of traumatic brain injury (TBI), occurring in up to 15-20% of patients with severe brain trauma. Trauma accounts for approximately 5% of chronic epilepsy in the community. Because it is a common condition, and because of the relatively short latency period between injury...

journal_title：Epilepsia

authors： Diaz-Arrastia R,Agostini MA,Madden CJ,Van Ness PC

更新日期：2009-02-01 00:00:00

abstract：:Generalized epilepsies are treatable with a number of antiepileptic drugs (AEDs) that are effective in different seizure types and epilepsy syndromes. The mechanisms of action of these AEDs are incompletely understood but include inhibition of low-threshold calcium currents and of voltage-gated sodium channels and fac...

journal_title：Epilepsia

authors： Berkovic SF

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To identify the brain networks that are involved in the different electroencephalography (EEG) abnormalities in patients with ring chromosome 20 [r(20)] syndrome. We hypothesize the existence of both distinctive and common brain circuits for the paroxysmal high voltage sharp waves (hSWs), the seizures, and th...

journal_title：Epilepsia

authors： Vaudano AE,Ruggieri A,Vignoli A,Avanzini P,Benuzzi F,Gessaroli G,Nichelli PF,Darra F,Cantalupo G,Mastrangelo M,Dalla Bernardina B,Canevini MP,Meletti S

更新日期：2014-03-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00

abstract：:To try to identify the critical structures during epileptogenesis, we used the lithium-pilocarpine model that reproduces most clinical and neuropathological features of temporal lobe epilepsy (TLE). We used imaging techniques as well as a disease modifying approach and pharmacological strategy. With [14C]-2-deoxygluco...

journal_title：Epilepsia

authors： André V,Dubé C,François J,Leroy C,Rigoulot MA,Roch C,Namer IJ,Nehlig A

更新日期：2007-01-01 00:00:00

abstract：:Surgical techniques may vary extensively between centers. We report on a web-based survey aimed at evaluating the current technical approaches in different centers around the world performing epilepsy surgery in children. The intention of the survey was to establish technical standards. A request was made to 88 center...

journal_title：Epilepsia

authors： Cukiert A,Rydenhag B,Harkness W,Cross JH,Gaillard WD,Task Force for Pediatric Epilepsy Surgery for the ILAE Commissions of Pediatrics and Surgical Therapies.

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To study cortical excitability after status epilepticus induced in two age groups of immature rats. METHODS:Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats. Control siblings received saline instead of pilocarpine. Interhemispheric responses were elicited by stimulati...

journal_title：Epilepsia

authors： Mares P,Tsenov G,Aleksakhina K,Druga R,Kubová H

更新日期：2005-01-01 00:00:00

abstract：:An animal model was used to study the effects of phenytoin on immune function. Inbred NFS mice, injected with phenytoin, 10-40 mg/kg, and immunized with bovine serum albumin (BSA), demonstrated a dose-dependent decrease in production of IgG antibodies to BSA. Phenytoin at the dosages used in this study did not appear ...

journal_title：Epilepsia

authors： Margaretten NC,Warren RP

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To confirm the efficacy and to clarify the problems of clobazam (CLB) as a new antiepileptic drug (AED) and clorazepate (CLP) as an alternative AED in Japan. METHODS:CLB and CLP were added on or replaced with conventional AEDs in 55 and 170 patients with refractory epilepsies, respectively. Short-term efficacy...

journal_title：Epilepsia

authors： Sugai K

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have doc...

journal_title：Epilepsia

authors： Couturier NH,Durand DM

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The substrate of seizure initiation in partial epilepsy is not well understood. Although many studies imply a focus that is will localized to a single structure, some information suggests that seizures arise regionally with simultaneous or near-simultaneous onset at several separate sites. To determine the phys...

journal_title：Epilepsia

authors： Bertram EH

更新日期：1997-01-01 00:00:00

abstract：:We studied the effect of antiepileptic drugs (AEDs) on internal carotid artery (ICA) blood flow velocity, as an index of total cerebral blood flow (CBF). The subjects were 45 newly diagnosed children with febrile convulsion or epilepsy who were seizure-free for a period long enough not to affect the results. They had ...

journal_title：Epilepsia

authors： Futagi Y,Otani K,Imai K

更新日期：1994-07-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00

abstract：:There is no doubt that structural morphological brain lesions and malformations in epilepsy represent major etiological factors for the cognitive impairments seen in this disease. The role of epileptic activity and seizures for cognition and cognitive development, however, is less easily determined. Epileptic dysfunct...

journal_title：Epilepsia

authors： Helmstaedter C

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

journal_title：Epilepsia

authors： Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

更新日期：2017-01-01 00:00:00

abstract：:Clinical course and long-term seizure prognosis were studied in 155 patients with complex-partial seizures during a follow-up of 10.1 +/- 1 (SD) years. In 79% of the patients generalized tonic-clonic seizures were recorded, mostly within the first 3 years of epilepsy but occurring as late as 20 years after the onset o...

journal_title：Epilepsia

authors： Schmidt D,Tsai JJ,Janz D

更新日期：1983-02-01 00:00:00