Very fast rhythmic activity on scalp EEG associated with epileptic spasms.

abstract：PURPOSE:To evaluate effects of vigabatrin (VGB) by using [123I]iomazenil single-photon emission computed tomography (SPECT) to estimate central gamma-aminobutyric acid (GABA(A))/benzodiazepine receptors (BZRs), and magnetic resonance spectroscopy (MRS) to assess tissue GABA levels. METHODS:Six patients with partial se...

journal_title：Epilepsia

authors： Verhoeff NP,Petroff OA,Hyder F,Zoghbi SS,Fujita M,Rajeevan N,Rothman DL,Seibyl JP,Mattson RH,Innis RB

更新日期：1999-10-01 00:00:00

abstract：:Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...

journal_title：Epilepsia

authors： Stefan H,Schäfer H,Kuhnen C,Schneider S

更新日期：1988-09-01 00:00:00

abstract：:Parenterally injected penicillin in rats induces a peculiar pattern of multifocal epilepsy. The effective amount is higher than that required in cats. The epileptiform activity initially appears on the cortical mantle of one hemisphere; after a variable delay, contralateral cortical spikes arise in a completely asynch...

journal_title：Epilepsia

authors： Fariello RG

更新日期：1976-06-01 00:00:00

abstract：PURPOSE:To determine whether differences in clinical manifestations of psychogenic nonepileptic events are associated with differences in outcome and whether the length of illness before diagnosis correlates with outcome. METHODS:We reviewed ictal videotapes and EEGs in 85 patients diagnosed with exclusively nonepilep...

journal_title：Epilepsia

authors： Selwa LM,Geyer J,Nikakhtar N,Brown MB,Schuh LA,Drury I

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RE...

journal_title：Epilepsia

authors： Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2010-05-01 00:00:00

abstract：:Circling seizures (CS) have been described in association with focal lesions as well as with generalized EEG discharges. We report 1 patient with juvenile myoclonic epilepsy (JME) who developed CS. There were no focal findings on clinical examination, EEG, or imaging studies. We propose that CS in this patient may rep...

journal_title：Epilepsia

authors： Lancman ME,Asconapé JJ,Golimstok A

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Ablation surgery has become the first line of treatment for hypothalamic hamartomas (HHs). For effective treatment, optimum targeting of ablation is mandatory. The present study aimed to evaluate the correspondence between the electrophysiological features of HHs and morphological targeting by semimicrorecord...

journal_title：Epilepsia

authors： Shirozu H,Masuda H,Kameyama S

更新日期：2020-12-01 00:00:00

abstract：:The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs...

journal_title：Epilepsia

authors： Coutinho-Netto J,Boyar MM,Abdul-Ghani AS,Bradford HF

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:The cardiac component of risk for sudden unexpected death in epilepsy (SUDEP) and alterations in cardiac risk by vagus nerve stimulation (VNS) are not well understood. We determined changes in T-wave alternans (TWA), a proven noninvasive marker of risk for sudden cardiac death in patients with cardiovascular ...

journal_title：Epilepsia

authors： Schomer AC,Nearing BD,Schachter SC,Verrier RL

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Effects of pre- and postsynaptic γ-aminobutyric acid B (GABA(B)) receptor activation were characterized in human tissue from epilepsy surgery. METHODS:Slices of human cortical tissue were investigated in a submerged-type chamber with intracellular recordings in layers II/III. Parallel experiments were performe...

journal_title：Epilepsia

authors： Teichgräber LA,Lehmann TN,Meencke HJ,Weiss T,Nitsch R,Deisz RA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures. It is known that metabolic crises in affected patients are precipitated by infections. Although growing evidence supports that inflammation facilitates sei...

journal_title：Epilepsia

authors： Salvadori MG,Banderó CR,Jesse AC,Gomes AT,Rambo LM,Bueno LM,Bortoluzzi VT,Oliveira MS,Mello CF

更新日期：2012-01-01 00:00:00

abstract：:To study the effect of age on seizure latency, intensity, reproducibility, and mortality in genetically epilepsy-prone rats of the severe colony (GEPR-9s), 472 seizure-naive rats, ranging in age from 14 to 65 days, received a series of three audiogenic stimulations. Both the percentage of rats having one or more seizu...

journal_title：Epilepsia

authors： Thompson JL,Carl FG,Holmes GL

更新日期：1991-03-01 00:00:00

abstract：:Cognitive impairment is the most common comorbidity in children with epilepsy, but its pathophysiology and predisposing conditions remain unknown. Clinical epilepsy characteristics are not conclusive in determining cognitive outcome. Because many children with epilepsy do not have macrostructural magnetic resonance im...

journal_title：Epilepsia

authors： Braakman HM,van der Kruijs SJ,Vaessen MJ,Jansen JF,Debeij-van Hall MH,Vles JS,Aldenkamp AP,Backes WH,Hofman PA

更新日期：2012-10-01 00:00:00

abstract：:Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how sei...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1999-01-01 00:00:00

abstract：:Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5-benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in ...

journal_title：Epilepsia

authors： Sivakumar S,Ibrahim M,Parker D Jr,Norris G,Shah A,Mohamed W

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...

journal_title：Epilepsia

authors： Ahmadiani A,Mandgary A,Sayyah M

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:The hippocampus is one of the principal target areas for neurosteroidal action, and the major neuroendocrine conversion of progesterone appears to be 5alpha-reduction and 3alpha-hydroxysteroid oxidoreduction, leading to the potent neurosteroid 3alpha,5alpha-tetrahydroxyprogesterone. To investigate whether the h...

journal_title：Epilepsia

authors： Stoffel-Wagner B,Beyenburg S,Watzka M,Blümcke I,Bauer J,Schramm J,Bidlingmaier F,Elger CE

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Identification of patients at risk of developing epilepsy before the first spontaneous seizure may promote the development of preventive treatment providing opportunity to stop or slow down the disease. METHODS:As development of novel radiotracers and on-site setup of existing radiotracers is highly time-con...

journal_title：Epilepsia

authors： Bascuñana P,Gendron T,Sander K,Jahreis I,Polyak A,Ross TL,Bankstahl M,Arstad E,Bankstahl JP

更新日期：2019-11-01 00:00:00

abstract：:Pharmacoresistance continues to be a challenging problem for a substantial number of epileptic patients and their attending physicians. In the past 10 years, we have made little progress in reducing the incidence of refractory epilepsy and have no innovative plans in place with the potential to do so. In this article,...

journal_title：Epilepsia

authors： Dichter MA

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, abl...

journal_title：Epilepsia

authors： Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Adult epilepsy studies have demonstrated cerebral and cerebellar volume reduction beyond the epileptogenic zone, correlating this with an inferior surgical outcome. We determined whether brain volumes were reduced in childhood epilepsy and the significance of this. METHODS:Cerebral, cerebellar, and hippocampal...

journal_title：Epilepsia

authors： Lawson JA,Vogrin S,Bleasel AF,Cook MJ,Bye AM

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...

journal_title：Epilepsia

authors： Strzelczyk A,Cenusa M,Bauer S,Hamer HM,Mothersill IW,Grunwald T,Hillenbrand B,Ebner A,Steinhoff BJ,Krämer G,Rosenow F

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:Precipitants of seizures are often reported by patients and carers, but the accuracy of these claims remains unknown. Focusing on epilepsy in people with intellectual disability (ID), the aims of this work were to (1) identify a set of methods for assessing the validity of reported seizure triggers in indivi...

journal_title：Epilepsia

authors： Illingworth JL,Watson P,Xu S,Manford M,Ring H

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:It has been suggested that multilobar epilepsies caused by lesions restricted to the posterior cerebral quadrant (ie, the parietal, temporal, and occipital lobes) can be treated successfully by a procedure termed posterior disconnection. The objective of the present paper was to identify determinants of the e...

journal_title：Epilepsia

authors： Kalbhenn T,Cloppenborg T,Wörmann FG,Blümcke I,Coras R,May TW,Polster T,Simon M,Bien CG

更新日期：2019-09-01 00:00:00

abstract：:A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care....

journal_title：Epilepsia

authors： Rawlings GH,Reuber M

更新日期：2018-06-01 00:00:00

abstract：:Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

journal_title：Epilepsia

authors： Rodin EA,Katz M,Lennox K

更新日期：1976-09-01 00:00:00

abstract：:Variants in the SCN2A gene, encoding the voltage-gated sodium channel NaV 1.2, cause a variety of neuropsychiatric syndromes with different severity ranging from self-limiting epilepsies with early onset to developmental and epileptic encephalopathy with early or late onset and intellectual disability (ID), as well as...

journal_title：Epilepsia

authors： Hedrich UBS,Lauxmann S,Lerche H

更新日期：2019-12-01 00:00:00

abstract：:Fluoxetine was evaluated for anticonvulsant effects in a rat model of focally evoked complex partial seizures (CPS) secondarily generalized. Fluoxetine was administered intraperitoneally (i.p.) 1 h before seizures were induced by focal intracerebral application of the GABAA receptor antagonist, bicuculline methiodide ...

journal_title：Epilepsia

authors： Prendiville S,Gale K

更新日期：1993-03-01 00:00:00

abstract：:Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated anim...

journal_title：Epilepsia

authors： Diehl RG,Smialowski A,Gotwo T

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...

journal_title：Epilepsia

authors： Lin Y,Harris DA,Curry DJ,Lam S

更新日期：2015-01-01 00:00:00