Role of the superior colliculus in the expression of acute and kindled audiogenic seizures in Wistar audiogenic rats.

Abstract:

PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, ablation of SC superficial and deep layers, and ablation of only the cerebral cortex were evaluated in the Wistar audiogenic rat (WAR) strain during acute and kindled audiogenic seizures. The audiogenic seizure kindling protocol started 4 days after surgeries, with two acoustic stimuli per day for 10 days. Acute audiogenic seizures were evaluated by a categorized seizure severity midbrain index (cSI) and kindled seizures by a severity limbic index (LI). RESULTS:All subcollicular transections reaching the deep layers of the SC abolished audiogenic seizures or significantly decreased cSI. In the unlesioned kindled group, a reciprocal relationship between limbic and brainstem pattern of seizures was seen. The increased number of stimuli provoked an audiogenic kindling phenomenon. Ablation of the entire SC (ablation group) or of the cerebral cortex only (ctx-operated group) hampered the acquisition of limbic behaviors. There was no difference in cSI and LI between the ctx-operated and ablation groups, but there was a difference between ctx-operated and the unlesioned kindled group. There was also no difference in cSI between SC deep layer transection and ablation groups. Results of histologic analyses were similar for acute and kindled audiogenic seizure groups. CONCLUSIONS:SC deep layers are involved in the expression of acute and kindled audiogenic seizure, and the cerebral cortex is essential for audiogenic kindling development.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

doi

10.1111/j.1528-1167.2009.02164.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

2563-74

issue

12

eissn

0013-9580

issn

1528-1167

pii

EPI2164

journal_volume

50

pub_type

杂志文章
  • Focal chronic inflammatory epileptic encephalopathy in a patient with malformations of cortical development, with a review of the spectrum of chronic inflammatory epileptic encephalopathy.

    abstract:PURPOSE:Chronic cellular inflammation closely associated with epilepsy without an active infection is a hallmark of Rasmussen encephalitis (RE). RE has typical and defining features lacking in other rare epilepsy patients who also have neocortical lymphocytes without an identifiable cause. A patient with malformations ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2007.01034.x

    authors: Rhodes RH,Lehman RM,Wu BY,Roychowdhury S

    更新日期:2007-06-01 00:00:00

  • Health care resource utilization before and after perampanel initiation among patients with epilepsy in the United States.

    abstract:OBJECTIVE:The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States. METHODS:Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyze...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13857

    authors: Faught E,Laliberté F,Wang Z,Barghout V,Haider B,Lejeune D,Germain G,Choi J,Wagh A,Duh MS

    更新日期:2017-10-01 00:00:00

  • Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.

    abstract:OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16624

    authors: Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

    更新日期:2020-09-01 00:00:00

  • Topiramate pharmacokinetics in infants.

    abstract:PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1528-1157.1999.tb00780.x

    authors: Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

    更新日期:1999-06-01 00:00:00

  • Value of electrical stimulation and high frequency oscillations (80-500 Hz) in identifying epileptogenic areas during intracranial EEG recordings.

    abstract:PURPOSE:Electrical stimulation (ES) is used during intracranial electroencephalography (EEG) investigations to delineate epileptogenic areas and seizure-onset zones (SOZs) by provoking afterdischarges (ADs) or patients' typical seizure. High frequency oscillations (HFOs--ripples, 80-250 Hz; fast ripples, 250-500 Hz) ar...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02389.x

    authors: Jacobs J,Zijlmans M,Zelmann R,Olivier A,Hall J,Gotman J,Dubeau F

    更新日期:2010-04-01 00:00:00

  • A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments.

    abstract::Phenytoin is metabolized to its parahydroxylated derivative by hepatic microsomal enzymes. This hydroxylation is a saturable process, that is, the rate of metabolism fails to increase in proportion to the serum concentration. This leads to a nonlinear relationship between the maintenance dose of the drug and the resul...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1975.tb04745.x

    authors: Richens A

    更新日期:1975-11-01 00:00:00

  • Risk of epilepsy in long-term survivors of surgery for aneurysmal subarachnoid hemorrhage: a population-based study in Iceland.

    abstract:PURPOSE:Epilepsy is known to result from aneurysmal subarachnoid hemorrhage (SAH). There are no population-based estimates of the absolute risk or the duration for which this risk is elevated. We have conducted a population-based study in Iceland of the risk of epilepsy after a ruptured cerebral aneurysm to address the...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb00326.x

    authors: Olafsson E,Gudmundsson G,Hauser WA

    更新日期:2000-09-01 00:00:00

  • Systematic testing of medical intractability for carbamazepine, phenytoin, and phenobarbital or primidone in monotherapy for patients considered for epilepsy surgery.

    abstract:PURPOSE:To assess medical intractability in patients considered for restrictive epilepsy surgery. METHODS:Seventy-four patients received single drug treatment with carbamazepine (CBZ), phenytoin (PHT), and either phenobarbital (PB) or primidone (PRM). Medical intractability was established if seizure control was not o...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1528-1157.1996.tb00632.x

    authors: Hermanns G,Noachtar S,Tuxhorn I,Holthausen H,Ebner A,Wolf P

    更新日期:1996-07-01 00:00:00

  • The diagnostic utility of intracranial EEG monitoring for epilepsy surgery in children.

    abstract:OBJECTIVE:There are limited data on the indications for the use of chronic invasive electroencephalography (EEG) monitoring (IEM) for pediatric epilepsy surgery. METHODS:We retrospectively studied 102 children who underwent intracranial monitoring to map critical cortex, localize the epileptogenic region, or resolve d...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12983

    authors: Brna P,Duchowny M,Resnick T,Dunoyer C,Bhatia S,Jayakar P

    更新日期:2015-07-01 00:00:00

  • Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.

    abstract:SUMMARY:Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries. Meta-analyses of randomized controlled trials suggest that few differences in efficacy exist between PB and other established AEDs, but its possible deleteri...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.0013-9580.2004.12704.x

    authors: Kwan P,Brodie MJ

    更新日期:2004-09-01 00:00:00

  • Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography.

    abstract:OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13010

    authors: King-Stephens D,Mirro E,Weber PB,Laxer KD,Van Ness PC,Salanova V,Spencer DC,Heck CN,Goldman A,Jobst B,Shields DC,Bergey GK,Eisenschenk S,Worrell GA,Rossi MA,Gross RE,Cole AJ,Sperling MR,Nair DR,Gwinn RP,Park YD,

    更新日期:2015-06-01 00:00:00

  • Changes of cortical interhemispheric responses after status epilepticus in immature rats.

    abstract:PURPOSE:To study cortical excitability after status epilepticus induced in two age groups of immature rats. METHODS:Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats. Control siblings received saline instead of pilocarpine. Interhemispheric responses were elicited by stimulati...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.01004.x

    authors: Mares P,Tsenov G,Aleksakhina K,Druga R,Kubová H

    更新日期:2005-01-01 00:00:00

  • Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.

    abstract:OBJECTIVE:Unresolved past stressful events can induce a state of vulnerability to epilepsy and comorbidities. Using an experimental model of stress-induced vulnerability to depression, we tested whether an antioxidant treatment applied after the onset of epileptogenesis was disease modifying and could prevent the occur...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.14692

    authors: Becker C,Mancic A,Ghestem A,Poillerat V,Claverie D,Bartolomei F,Brouillard F,Benoliel JJ,Bernard C

    更新日期:2019-04-01 00:00:00

  • Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy.

    abstract:PURPOSE:Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. METHODS:We studied pre- and postoperative neuropsychological test res...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1998.tb01174.x

    authors: Szabó CA,Wyllie E,Stanford LD,Geckler C,Kotagal P,Comair YG,Thornton AE

    更新日期:1998-08-01 00:00:00

  • Status epilepticus in scrub typhus.

    abstract::Scrub typhus is an emerging infection, and there is little information about status epilepticus (SE) in scrub typhus. We report the clinical spectrum and outcome of SE in scrub typhus. In a 3-year prospective hospital-based observational study, all scrub typhus patients with SE were included. Scrub typhus was diagnose...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13412

    authors: Kalita J,Mani VE,Bhoi SK,Misra UK

    更新日期:2016-07-01 00:00:00

  • Mechanistic hypotheses for nonsynaptic epileptiform activity induction and its transition from the interictal to ictal state--computational simulation.

    abstract:PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01686.x

    authors: de Almeida AC,Rodrigues AM,Scorza FA,Cavalheiro EA,Teixeira HZ,Duarte MA,Silveira GA,Arruda EZ

    更新日期:2008-11-01 00:00:00

  • Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.

    abstract:OBJECTIVE:Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have doc...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.14595

    authors: Couturier NH,Durand DM

    更新日期:2018-12-01 00:00:00

  • Cognitive dysfunction associated with antiepileptic drug therapy.

    abstract::Epilepsy is frequently associated with cognitive dysfunction. However, the reasons for this correlation are unclear. Possible influential factors include patient age; duration, frequency, etiology, and type of seizures; hereditary factors; psychosocial issues; and antiepileptic drug (AED) therapy. Whereas many of thes...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1157.1987.tb05767.x

    authors: Vining EP

    更新日期:1987-01-01 00:00:00

  • Surgical strategy and outcomes for epileptic patients with focal cortical dysplasia or dysembryoplastic neuroepithelial tumor.

    abstract:PURPOSE:The purpose of this study was to clarify and compare the influence of surgical strategy on relief from seizures in patients with focal cortical dysplasia (FCD) and those with dysembryoplastic neuroepithelial tumor (DNT). METHODS:Six patients with FCD and five patients with DNT, all of whom underwent surgical r...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:

    authors: Kameyama S,Fukuda M,Tomikawa M,Morota N,Oishi M,Wachi M,Kanazawa O,Sasagawa M,Kakita A,Takahashi H

    更新日期:2001-01-01 00:00:00

  • Bilateral Rasmussen encephalitis: postmortem documentation in a five-year-old.

    abstract::A case of Rasmussen encephalitis with bilateral involvement and onset at age 2 years is reviewed. Rasmussen encephalitis is a rare progressive disease that causes intractable seizures, cognitive decline, and inflammatory changes in the brain. The neurologic involvement is characteristically unilateral. Bilateral invol...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2003.36602.x

    authors: Tobias SM,Robitaille Y,Hickey WF,Rhodes CH,Nordgren R,Andermann F

    更新日期:2003-01-01 00:00:00

  • The value of EEG-fMRI and EEG source analysis in the presurgical setup of children with refractory focal epilepsy.

    abstract:PURPOSE:In the presurgical evaluation of children and juvenile patients with refractory focal epilepsy, the main challenge is to localize the point of seizure onset as precisely as possible. We compared results of the conventional electroencephalography-functional magnetic resonance imaging (EEG-fMRI) analysis with tho...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2012.03587.x

    authors: Elshoff L,Groening K,Grouiller F,Wiegand G,Wolff S,Michel C,Stephani U,Siniatchkin M

    更新日期:2012-09-01 00:00:00

  • Incidence of first epileptic seizures in the canton of Geneva, Switzerland.

    abstract:PURPOSE:We wished to determine the incidence of first provoked and nonprovoked epileptic seizures in the canton of Geneva, Switzerland. METHODS:Between June 1, 1990 and May 31, 1991, we collected all cases of suspected epileptic seizures referred to the two hospitals of the county of Geneva, Switzerland and to the pri...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1997.tb01139.x

    authors: Jallon P,Goumaz M,Haenggeli C,Morabia A

    更新日期:1997-05-01 00:00:00

  • How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years.

    abstract::Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

    journal_title:Epilepsia

    pub_type: 历史文章,杂志文章

    doi:10.1111/epi.12026

    authors: Yasiry Z,Shorvon SD

    更新日期:2012-12-01 00:00:00

  • Blood-brain barrier dysfunction in brain diseases: clinical experience.

    abstract::The blood-brain barrier, a unique feature of the cerebral vasculature, is gaining attention as a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy, and schizophrenia. Although acute blood-brain barrier dysfunction can induce cerebral edema, seizures, or neuropsychiatric symptoms...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2012.03697.x

    authors: Schoknecht K,Shalev H

    更新日期:2012-11-01 00:00:00

  • Which anesthetic should be used in the treatment of refractory status epilepticus?

    abstract::While the treatment of refractory status epilepticus (SE) relies on the use of anesthetic agents, mostly barbiturates, propofol, or midazolam, the study of the available literature discloses that the evidence level is low. Therapeutic coma induction appears straightforward for generalized convulsive or subtle SE, but ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2007.01350.x

    authors: Rossetti AO

    更新日期:2007-01-01 00:00:00

  • An evaluation of the impact of health worker and patient education on the care and compliance of patients with epilepsy in Zimbabwe.

    abstract:PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb00749.x

    authors: Adamolekun B,Mielke JK,Ball DE

    更新日期:1999-04-01 00:00:00

  • Long-term EEG-video-audio monitoring: detection of partial epileptic seizures and psychogenic episodes by 24-hour EEG record review.

    abstract::Twenty-seven patients with medically refractory paroxysmal disorders underwent EEG-video-audio (EVA) monitoring in an inpatient neurology-neurosurgery unit over 1-15 (mean 8.9) days. Fast visual review of all EEG records (5,784 h) and subsequent analysis of synchronized EVA patterns demonstrated a total of 208 partial...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1989.tb05465.x

    authors: Pierelli F,Chatrian GE,Erdly WW,Swanson PD

    更新日期:1989-09-01 00:00:00

  • Seizure outcomes in patients with anti-NMDAR encephalitis: A follow-up study.

    abstract:OBJECTIVE:To evaluate the long-term seizure outcome and potential factors associated with seizure outcome in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. METHODS:In the setting of a prospective, single-center, longitudinal cohort study, 109 patients were evaluated with ongoing follow-up....

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13929

    authors: Liu X,Yan B,Wang R,Li C,Chen C,Zhou D,Hong Z

    更新日期:2017-12-01 00:00:00

  • A screening test for the prediction of Dravet syndrome before one year of age.

    abstract:PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2007.01475.x

    authors: Hattori J,Ouchida M,Ono J,Miyake S,Maniwa S,Mimaki N,Ohtsuka Y,Ohmori I

    更新日期:2008-04-01 00:00:00

  • MRI-negative temporal lobe epilepsy-What do we know?

    abstract::Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/epi.13699

    authors: Muhlhofer W,Tan YL,Mueller SG,Knowlton R

    更新日期:2017-05-01 00:00:00