Abstract:
:A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory results included positive ANA, rheumatoid factor, anti-NIA, circulating immune complexes, and antihistone antibody. The patient was treated with high dosage prednisone with partial improvement, but continued to have exacerbations at lower dosages. Fourteen months later, VPA was discontinued, and rapid improvement ensued. Prednisone was subsequently discontinued, and the patient has now maintained normal platelet counts for 18 months.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Asconapé JJ,Manning KR,Lancman MEdoi
10.1111/j.1528-1157.1994.tb02927.xsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
162-3issue
1eissn
0013-9580issn
1528-1167journal_volume
35pub_type
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