Abstract:
:The teratological effect of nicotine has been studied during different trimesters of pregnancy. Three groups of pregnant albino Swiss mice were used for each trimester. The daily doses of nicotine base used were equivalent to 10 (900 micrograms/kg), 20 (1,800 micrograms/kg), or 30 (2,700 micrograms/kg) cigarettes. The control groups were given normal saline. The drug and the saline solution were administered subcutaneously. The results showed that prenatal nicotine prolonged the latency and delayed the onset and extinction of audiogenic seizures in the offspring. These effects were more pronounced during the third trimester and particularly with the largest dose. These findings indicate that prenatal nicotine might delay the postnatal development of the CNS if it is given during the late stage of pregnancy.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Al-Hachim GM,Mahmoud FAdoi
10.1111/j.1528-1157.1985.tb05708.xsubject
Has Abstractpub_date
1985-11-01 00:00:00pages
661-5issue
6eissn
0013-9580issn
1528-1167journal_volume
26pub_type
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