Abstract:
PURPOSE:To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model for murine absence seizures, after gamma-aminobutyric acid (GABA)(B) modulation.
METHODS:The animals were first tested with the GABA(B) agonist l-baclofen followed by the GABA(B) antagonist SCH 50911. Moreover, digital EEGs recorded under experimental conditions were processed at baseline and 10 and 20 min after l-baclofen injection. This procedure was followed by injection of the GABA(B) antagonist SCH50911 and by an additional EEG evaluation at 10 and 20 min from drug administration. The power spectra analysis of signals was obtained for delta (0.5-3 Hz), theta (3.5-7.5 Hz), alpha (8-12 Hz), beta (13-20 Hz), and gamma (21-50 Hz) frequencies.
RESULTS:The spiking pattern and power spectrum of beta activity was increased by
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Marrosu F,Santoni F,Fà M,Puligheddu M,Barberini L,Genugu F,Frau R,Manunta M,Mereu Gdoi
10.1111/j.1528-1167.2006.00456.xsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
489-94issue
3eissn
0013-9580issn
1528-1167pii
EPI456journal_volume
47pub_type
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