Abstract:
:Magnetic resonance imaging (MRI) is effective in demonstrating pathologic lesions in patients with epilepsy. It has been suggested that MRI might also reveal functional abnormalities at an interictal epileptic focus when no gross structural change such as gliosis or tumor is present. Experimental epileptic foci were produced by topical application of penicillin to the cortex of rats. In vitro proton nuclear magnetic resonance (NMR) relaxometry of tissue excised from the experimental foci revealed an increase in spin-echo relaxation time as compared to that in control tissue. The elevated relaxation times occurred in tissue samples from areas of active electroencephalographic (EEG) spiking. This is the first direct demonstration of an alteration in proton magnetic resonance parameters by functional abnormalities (focal interictal spike activity) in the brain, supporting the concept that MRI might be similarly affected.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
McLachlan RS,Karlik SJ,Myles Vdoi
10.1111/j.1528-1157.1988.tb03737.xsubject
Has Abstractpub_date
1988-07-01 00:00:00pages
396-400issue
4eissn
0013-9580issn
1528-1167journal_volume
29pub_type
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