Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats.

abstract：:Clobazam was compared with placebo as antiepileptic adjunct medication in 129 therapy-resistant epileptic patients who were mainly suffering from complex partial seizures. The study was performed in five European countries according to a double-blind crossover design lasting 7 months. Two treatment periods of 3 months...

journal_title：Epilepsia

authors： Koeppen D,Baruzzi A,Capozza M,Chauvel P,Courjon J,Favel P,Harmant J,Lorenz H,Oller FV,Procaccianti G

更新日期：1987-09-01 00:00:00

abstract：:Genetic factors play a major role in the etiology of juvenile myoclonic epilepsy (JME), a common form of idiopathic generalized epilepsy, but so far, genes related to JME remain largely unknown. JME shares electroclinical features with Unverricht-Lundborg disease (progressive myoclonic epilepsy type 1; EPM1), a form o...

journal_title：Epilepsia

authors： Mumoli L,Tarantino P,Michelucci R,Bianchi A,Labate A,Franceschetti S,Marini C,Striano P,Gagliardi M,Ferlazzo E,Sofia V,Pennese L,Annesi G,Aguglia U,Guerrini R,Zara F,Gambardella A,Genetic Commission, Italian League Agai

更新日期：2015-04-01 00:00:00

abstract：:We report the history of a 14-year-old girl with atypical childhood occipital epilepsy "Gastaut type" whose first generalized tonic-clonic seizure was preceded by migraine without aura and followed by a status migrainosus. This status lasted for 3 days despite standard analgesic therapy. An EEG recording revealed an o...

journal_title：Epilepsia

authors： Parisi P,Kasteleijn-Nolst Trenité DG,Piccioli M,Pelliccia A,Luchetti A,Buttinelli C,Villa MP

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:This study was designed to quantify the relation between expressions of NMDA receptor (NMDAR) subunits (1 and 2A/B) and the epileptogenicity in human focal cortical dysplasia. METHODS:Immunoblotting and immunoprecipitation were used to quantify these receptor subunits in tissue resected from EEG-verified epile...

journal_title：Epilepsia

authors： Mikuni N,Babb TL,Ying Z,Najm I,Nishiyama K,Wylie C,Yacubova K,Okamoto T,Bingaman W

更新日期：1999-12-01 00:00:00

abstract：:Eyelid myoclonia with absences (EMA), or Jeavons syndrome, is a generalized epileptic condition clinically characterized by eyelid myoclonia (EM) with or without absences, eye closure-induced electroencephalography (EEG) paroxysms, and photosensitivity; in addition, rare tonic-clonic seizures may also occur. Although ...

journal_title：Epilepsia

authors： Striano S,Capovilla G,Sofia V,Romeo A,Rubboli G,Striano P,Trenité DK

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Epileptic spasms are seizures that occur predominantly in children and are characterized by clusters of brief axial movements. Epileptic spasms may occur in the context of a variety of syndromes. Previous research has found that epileptic spasms occur in a sleep/wake and diurnal rhythm. The purpose of this stud...

journal_title：Epilepsia

authors： Ramgopal S,Shah A,Zarowski M,Vendrame M,Gregas M,Alexopoulos AV,Loddenkemper T,Kothare SV

更新日期：2012-07-01 00:00:00

abstract：:Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of v...

journal_title：Epilepsia

authors： Meldrum BS

更新日期：1997-01-01 00:00:00

abstract：:A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care....

journal_title：Epilepsia

authors： Rawlings GH,Reuber M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To evaluate the changes in serum sex hormones of gonadal or adrenal origin, the gonadotropic hormones, and sex hormone-binding globulin (SHBG) in men and women with chronic temporal lobe epilepsy (TLE), who are undergoing monotherapy with carbamazepine or receiving carbamazepine in combination with other antico...

journal_title：Epilepsia

authors： Stoffel-Wagner B,Bauer J,Flügel D,Brennemann W,Klingmüller D,Elger CE

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To assess the visual system excitability of photosensitive patients with idiopathic generalized epilepsy (IGE) with the paired-pulse flash-evoked potential (paired F-VEP) technique. METHODS:We studied 19 photosensitive patients with IGE (16 women) showing a photoparoxysmal electroencephalographic (EEG) respons...

journal_title：Epilepsia

authors： Strigaro G,Prandi P,Varrasi C,Monaco F,Cantello R

更新日期：2012-04-01 00:00:00

abstract：:Medically intractable tonic and atonic seizures may be responsive to either vagus nerve stimulation (VNS) or corpus callosum section. VNS has been shown to be effective and is associated with very low morbidity. Callosotomy is a more ambitious procedure, with a higher risk of complications but greater likelihood of se...

journal_title：Epilepsia

authors： Rosenfeld WE,Roberts DW

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...

journal_title：Epilepsia

authors： Wass CT,Grady RE,Fessler AJ,Cascino GD,Lozada L,Bechtle PS,Marsh WR,Sharbrough FW,Schroeder DR

更新日期：2001-10-01 00:00:00

abstract：:The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus ...

journal_title：Epilepsia

authors： McDaniel SS,Rensing NR,Thio LL,Yamada KA,Wong M

更新日期：2011-03-01 00:00:00

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Glutamate-gated N-methyl-d-aspartate receptors (NMDARs) are instrumental to brain development and functioning. Defects in the GRIN2A gene, encoding the GluN2A subunit of NMDARs, cause slow-wave sleep (SWS)-related disorders of the epilepsy-aphasia spectrum (EAS). The as-yet poorly understood developmental seq...

journal_title：Epilepsia

authors： Salmi M,Del Gallo F,Minlebaev M,Zakharov A,Pauly V,Perron P,Pons-Bennaceur A,Corby-Pellegrino S,Aniksztejn L,Lenck-Santini PP,Epsztein J,Khazipov R,Burnashev N,Bertini G,Szepetowski P

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...

journal_title：Epilepsia

authors： King-Stephens D,Mirro E,Weber PB,Laxer KD,Van Ness PC,Salanova V,Spencer DC,Heck CN,Goldman A,Jobst B,Shields DC,Bergey GK,Eisenschenk S,Worrell GA,Rossi MA,Gross RE,Cole AJ,Sperling MR,Nair DR,Gwinn RP,Park YD,

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To analyze activity of identified dentate gyrus granular cells and interneurons during pathologic high-frequency oscillations (pHFOs). METHODS:Pilocarpine-treated epileptic mice were anesthetized with urethane and ketamine. Their heads were fixed in a stereotaxic frame. Extracellular unit activity was recoded ...

journal_title：Epilepsia

authors： Bragin A,Benassi SK,Kheiri F,Engel J Jr

更新日期：2011-01-01 00:00:00

abstract：:An understanding of the basic principles of human inheritance patterns is necessary to appreciate the variety and complexity of genetic influences in the epilepsies. The various modes of human inheritance include single gene (mendelian), chromosomal, mitochondrial, and multifactorial/polygenic. Recent insights regardi...

journal_title：Epilepsia

authors： Bird TD

更新日期：1994-01-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is effective in demonstrating pathologic lesions in patients with epilepsy. It has been suggested that MRI might also reveal functional abnormalities at an interictal epileptic focus when no gross structural change such as gliosis or tumor is present. Experimental epileptic foci were p...

journal_title：Epilepsia

authors： McLachlan RS,Karlik SJ,Myles V

更新日期：1988-07-01 00:00:00

abstract：:The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs dur...

journal_title：Epilepsia

authors： Mikkelsen B,Berggreen P,Joensen P,Kristensen O,Køhler O,Mikkelsen BO

更新日期：1981-08-01 00:00:00

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：:A multicenter prospective study was initiated at the time of first antiepileptic treatment for afebrile seizures with 283 unselected patients in Italy. Each patient started with monotherapy at standard daily doses. Data were collected at admission, at scheduled 6-month exams, and at unscheduled exams and included age,...

journal_title：Epilepsia

authors： Beghi E,Tognoni G

更新日期：1988-05-01 00:00:00

abstract：:Determining a prognosis for functional recovery after prolonged status epilepticus can be difficult. Prior case studies have shown that despite seizure control, functional outcomes are typically poor unless a reversible cause is identified. Herein we present a case of idiopathic status epilepticus with a surprisingly ...

journal_title：Epilepsia

authors： Standley K,Abdulmassih R,Benbadis S

更新日期：2012-01-01 00:00:00

abstract：:This article reviews the potential interactions of antiepileptic drugs (AEDs) and the pharmacokinetic and pharmacodynamic principles involved. It describes the absorptive and distributive properties of AEDs and the effects on protein binding, hepatic metabolism, and elimination resulting from co-administration of AEDs...

journal_title：Epilepsia

authors： French JA,Gidal BE

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Dravet syndrome (DS) or severe myoclonic epilepsy of infancy is an intractable epileptic encephalopathy of early childhood that is caused by a mutation in the SCN1A gene in most patients. The aim of this study was to identify a syndrome-specific epileptic network underlying interictal epileptiform discharges (I...

journal_title：Epilepsia

authors： Moehring J,von Spiczak S,Moeller F,Helbig I,Wolff S,Jansen O,Muhle H,Boor R,Stephani U,Siniatchkin M

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To study cortical excitability after status epilepticus induced in two age groups of immature rats. METHODS:Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats. Control siblings received saline instead of pilocarpine. Interhemispheric responses were elicited by stimulati...

journal_title：Epilepsia

authors： Mares P,Tsenov G,Aleksakhina K,Druga R,Kubová H

更新日期：2005-01-01 00:00:00

abstract：:We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...

journal_title：Epilepsia

authors： Venkateswaran S,Myers KA,Smith AC,Beaulieu CL,Schwartzentruber JA,FORGE Canada Consortium.,Majewski J,Bulman D,Boycott KM,Dyment DA

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Prior studies have given conflicting data concerning the association of benign rolandic epilepsy of childhood (BREC) and migraine but were limited by lack of sensitive, diagnostic criteria for childhood migraine. By using revised International Headache Society (IHS-R) criteria, we compared the prevalence of mig...

journal_title：Epilepsia

authors： Wirrell EC,Hamiwka LD

更新日期：2006-10-01 00:00:00