Abstract:
:The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
McDaniel SS,Rensing NR,Thio LL,Yamada KA,Wong Mdoi
10.1111/j.1528-1167.2011.02981.xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
e7-11issue
3eissn
0013-9580issn
1528-1167journal_volume
52pub_type
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