The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway.


:The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition.






McDaniel SS,Rensing NR,Thio LL,Yamada KA,Wong M




Has Abstract


2011-03-01 00:00:00












  • Development of an epilepsy-specific risk adjustment comorbidity index.

    abstract:PURPOSE:To develop an epilepsy-specific comorbidity risk adjustment index for mortality outcomes research. METHODS:Data were extracted from five linked administrative databases in Calgary, Canada from April 1, 1996 to March 31, 2004. Epilepsy patients were defined using a validated ICD-9-CM- and ICD-10-CA-based case d...


    pub_type: 杂志文章


    authors: St Germaine-Smith C,Liu M,Quan H,Wiebe S,Jette N

    更新日期:2011-12-01 00:00:00

  • Phasic GABAA -receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus.

    abstract:PURPOSE:  Despite the consistent observation that γ-aminobutyric acid A (GABA(A) ) receptors mediate excitatory responses at perinatal stages, the role of the GABAergic system in the generation of neonatal epileptiform activity remains controversial. Therefore, we analyzed whether tonic and phasic GABAergic transmissio...


    pub_type: 杂志文章


    authors: Kolbaev SN,Sharopov S,Dierkes PW,Luhmann HJ,Kilb W

    更新日期:2012-05-01 00:00:00

  • Neurocognitive profiles in children with epilepsy.

    abstract:PURPOSE:The presence of specific neurocognitive deficits may help explain why school achievement and psychosocial functioning are often worse in children with epilepsy than would be predicted by their global intellectual functioning. This study compared children with two forms of epilepsy: localization-related epilepsy...


    pub_type: 杂志文章


    authors: Kernan CL,Asarnow R,Siddarth P,Gurbani S,Lanphier EK,Sankar R,Caplan R

    更新日期:2012-12-01 00:00:00

  • Classification of epileptic seizures: a hospital-based study of 1,250 patients in a developing country.

    abstract::The 1981 International Classification of Epileptic Seizures (ICES) was used to study the distribution of seizure types in 1,250 patients attending an Epilepsy Clinic in Sri Lanka. Based on seizure symptomatology 94.6% of the cases could be classified, and by adding the routine interictal EEG findings the percentage of...


    pub_type: 杂志文章


    authors: Senanayake N

    更新日期:1993-09-01 00:00:00

  • The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy.

    abstract::This study evaluated the effects of depression and anxiety disorder symptoms on the health-related quality of life (HRQOL) of children and adolescents with epilepsy. Sixty children and adolescents and their parents participated in the study. Symptoms of anxiety disorders were identified by the Screen for Child Anxiety...


    pub_type: 杂志文章


    authors: Stevanovic D,Jancic J,Lakic A

    更新日期:2011-08-01 00:00:00

  • Assessing the validity of using administrative data to identify patients with epilepsy.

    abstract:OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...


    pub_type: 杂志文章,随机对照试验


    authors: Tu K,Wang M,Jaakkimainen RL,Butt D,Ivers NM,Young J,Green D,Jetté N

    更新日期:2014-02-01 00:00:00

  • Cellular localization and functional significance of CYP3A4 in the human epileptic brain.

    abstract:PURPOSE:Compelling evidence supports the presence of P450 enzymes (CYPs) in the central nervous system (CNS). However, little information is available on the localization and function of CYPs in the drug-resistant epileptic brain. We have evaluated the pattern of expression of the specific enzyme CYP3A4 and studied its...


    pub_type: 杂志文章


    authors: Ghosh C,Marchi N,Desai NK,Puvenna V,Hossain M,Gonzalez-Martinez J,Alexopoulos AV,Janigro D

    更新日期:2011-03-01 00:00:00

  • Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures.

    abstract::The effects of seizures on the hypocretin/orexin system have not yet been investigated in epileptic patients. The present study aimed to assay hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized tonic-clonic (GTC) seizures. Study groups consisted of 21 patients after GTC seizures and 19 control...


    pub_type: 杂志文章


    authors: Rejdak K,Papuć E,Grieb P,Stelmasiak Z

    更新日期:2009-06-01 00:00:00

  • Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent.

    abstract:PURPOSE:Previous studies have shown that the immunosuppressant cyclosporin A (CsA), a specific blocker of the mitochondrial permeability transition (MPT) pore, can dramatically ameliorate the selective neuronal necrosis resulting from ischemia-reperfusion, traumatic brain injury, and N-methyl-d-aspartate (NMDA)-evoked ...


    pub_type: 杂志文章


    authors: Santos JB,Schauwecker PE

    更新日期:2003-08-01 00:00:00

  • Metabolic changes in neuronal migration disorders: evaluation by combined MRI and proton MR spectroscopy.

    abstract:PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...


    pub_type: 杂志文章


    authors: Simone IL,Federico F,Tortorella C,De Blasi R,Bellomo R,Lucivero V,Carrara D,Bellacosa A,Livrea P,Carella A

    更新日期:1999-07-01 00:00:00

  • Do recent seizures and recent changes in antiepileptic drugs impact performances on neuropsychological tests in subtle ways that might easily be missed?

    abstract:PURPOSE:The possibility that a recent seizure or a recent change in antiepileptic medication might produce an occult change in neuropsychological performance is of interest, and especially so in the context of evaluation for epilepsy surgery. Such an evaluation is often done in a setting of video-EEG monitoring where a...


    pub_type: 杂志文章


    authors: Dodrill CB,Ojemann GA

    更新日期:2007-10-01 00:00:00

  • Epileptic seizures and pseudoseizures from the viewpoint of the hierarchy of consciousness.

    abstract::Epileptic seizures and pseudoseizures in temporal lobe epilepsies were studied from the viewpoint of the hierarchy of consciousness. Twenty-two patients with temporal lobe epilepsies (TLE) who showed true amnesia or impairment of consciousness developing from the dreamy state, even though their actions and movement co...


    pub_type: 杂志文章


    authors: Oana Y

    更新日期:1998-01-01 00:00:00

  • Nonmanipulative proximal upper extremity automatisms lateralize contralaterally in temporal lobe epilepsy.

    abstract:PURPOSE:Upper extremity automatisms are considered to be an ipsilateral seizure lateralizing sign in temporal lobe epilepsy (TLE). Herein we describe different types of contralateral upper extremity automatisms (CUEAs). METHODS:One hundred ninety-three video-(electroencephalography) EEG recordings of 59 patients were ...


    pub_type: 杂志文章


    authors: Kelemen A,Fogarasi A,Borbély C,Szucs A,Fabó D,Jakus R,Rásonyi G,Halász P

    更新日期:2010-02-01 00:00:00

  • Voxel-based magnetic resonance image postprocessing in epilepsy.

    abstract:OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...


    pub_type: 杂志文章


    authors: Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

    更新日期:2017-09-01 00:00:00

  • The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus.

    abstract::The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiep...


    pub_type: 杂志文章


    authors: Wheless JW,Treiman DM

    更新日期:2008-12-01 00:00:00

  • Cinromide in the treatment of absence seizures.

    abstract::Cinromide (BW-122U) was evaluated in an open pilot study of absence seizures in three naive (previously untreated for absence seizures) patients (one male and two females, 7 to 8 years of age). In these naive patients, cinromide was found to be well tolerated but ineffective in reducing generalized spike-and-wave disc...


    pub_type: 杂志文章


    authors: Corwin HM,Dreifuss FE

    更新日期:1983-08-01 00:00:00

  • Progressive myoclonus epilepsies: clinical and genetic aspects.

    abstract::The progressive myoclonus epilepsies (PMEs) are a group of rare genetic disorders previously shrouded in nosological confusion. Recent advances have clarified the features of these disorders and provided a rational approach to diagnosis. The major causes of PME are now known to be Unverricht-Lundborg disease, myoclonu...


    pub_type: 杂志文章,评审


    authors: Berkovic SF,Cochius J,Andermann E,Andermann F

    更新日期:1993-01-01 00:00:00

  • Epilepsy in general practice: the Dutch situation.

    abstract::Treatment and supervision of epileptic patients is part of specialist medicine. A possible change in the role of specialists and general practitioners in the care of these patients was explored by a questionnaire mailed to all Dutch neurologists and a random sample of general practitioners. Patients were also asked th...


    pub_type: 杂志文章


    authors: Rutgers MJ

    更新日期:1986-11-01 00:00:00

  • Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices.

    abstract::Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...


    pub_type: 杂志文章


    authors: Zhang CL,Gloveli T,Heinemann U

    更新日期:1994-01-01 00:00:00

  • Multiple subpial transection for control of epileptic seizures: effectiveness and safety.

    abstract:PURPOSE:To assess the efficacy and safety of multiple subpial transection (MST), a new technique in epilepsy surgery, alone and in combination with resection. METHODS:MST was performed in 22 patients with intractable epilepsy, 10 of whom were treated with a combination of a resection and MST in functionally important ...


    pub_type: 杂志文章


    authors: Hufnagel A,Zentner J,Fernandez G,Wolf HK,Schramm J,Elger CE

    更新日期:1997-06-01 00:00:00

  • Models and mechanisms of experimental epilepsies.

    abstract:PURPOSE:To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS:The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic dis...


    pub_type: 杂志文章,评审


    authors: Jefferys JG

    更新日期:2003-01-01 00:00:00

  • Knowledge, attitudes, and perceptions of epilepsy in Asia: toward a uniform study protocol.

    abstract:PURPOSE:Knowledge, attitudes, and perceptions of epilepsy (KAPE) among the public play a major role in determining the extent to which people with epilepsy can be integrated into their society. KAPE SURVEYS IN ASIA:Surveys conducted among Chinese in China, Taiwan, Malaysia, Singapore, and Hong Kong demonstrated simila...


    pub_type: 杂志文章


    authors: Lim SH,Pan A

    更新日期:2005-01-01 00:00:00

  • Pediatric language mapping: sensitivity of neurostimulation and Wada testing in epilepsy surgery.

    abstract:PURPOSE:Functional mapping of eloquent cortex with electrical neurostimulation is used both intra- and extraoperatively to tailor resections. In pediatric patients, however, functional mapping studies frequently fail to localize language. Wada testing has also been reported to be less sensitive in children. METHODS:Th...


    pub_type: 杂志文章


    authors: Schevon CA,Carlson C,Zaroff CM,Weiner HJ,Doyle WK,Miles D,Lajoie J,Kuzniecky R,Pacia S,Vazquez B,Luciano D,Najjar S,Devinsky O

    更新日期:2007-03-01 00:00:00

  • Longitudinal stability of interictal spikes in benign epilepsy with centrotemporal spikes.

    abstract:OBJECTIVE:To describe the natural history of electroencephalography (EEG) changes in patients with benign epilepsy with centrotemporal spikes (BECTS) over 1 year. METHODS:Centrotemporal spikes were visually evaluated based on 24-h ambulatory EEG studies to determine the total, left, right, and bilateral centrotemporal...


    pub_type: 杂志文章


    authors: Tenney JR,Glauser T,Altaye M,Szaflarski JP,Spencer C,Morita D,Vannest J

    更新日期:2016-05-01 00:00:00

  • Evaluation of case reports of aplastic anemia among patients treated with felbamate.

    abstract:PURPOSE:Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported. To elucidate the putative association between FBM and aplastic anemia, we made a detailed evaluation of...


    pub_type: 杂志文章,评审


    authors: Kaufman DW,Kelly JP,Anderson T,Harmon DC,Shapiro S

    更新日期:1997-12-01 00:00:00

  • Deep brain stimulation of the subthalamic nucleus as adjunct treatment for refractory epilepsy.

    abstract:PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...


    pub_type: 杂志文章


    authors: Handforth A,DeSalles AA,Krahl SE

    更新日期:2006-07-01 00:00:00

  • Combined study of the pattern of spontaneous activity of cerebellar Purkinje cells and phenytoin serum levels in the rat.

    abstract::The effects of phenytoin (PHT) on the spontaneous activity of cerebellar Purkinje cells and the drug serum levels have been examined following both intravenous and intraperitoneal administration in rats. Purkinje cell activity was assessed by on-line computer analysis of interspike interval distributions. PHT levels w...


    pub_type: 杂志文章


    authors: Latham A,Paul DH

    更新日期:1980-12-01 00:00:00

  • Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.

    abstract:PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...


    pub_type: 杂志文章


    authors: Ahmadiani A,Mandgary A,Sayyah M

    更新日期:2003-05-01 00:00:00

  • Quantitative magnetic resonance imaging evidence for altered structural remodeling of the temporal lobe in West syndrome.

    abstract:OBJECTIVE:To explore the structure-function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). METHODS:Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based ...


    pub_type: 杂志文章,多中心研究


    authors: Fosi T,Chu C,Chong WK,Clark C,Scott RC,Boyd S,De Haan M,Neville B

    更新日期:2015-04-01 00:00:00

  • Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice.

    abstract:PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...


    pub_type: 杂志文章


    authors: Zarnowska I,Luszczki JJ,Zarnowski T,Buszewicz G,Madro R,Czuczwar SJ,Gasior M

    更新日期:2009-05-01 00:00:00