Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.

abstract：:Previous studies have demonstrated that bicuculline-induced seizures of 1-2 h in duration lead to structural, metabolic, and circulatory alterations in the rat brain. Such alterations were observed even though cerebral oxygenation seemed adequate. In the present study, we explored whether pentylenetetrazole, a convuls...

journal_title：Epilepsia

authors： Ingvar M,Söderfeldt B,Folbergrová J,Kalimo H,Olsson Y,Siesjö BK

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...

journal_title：Epilepsia

authors： Powell KL,Tang H,Ng C,Guillemain I,Dieuset G,Dezsi G,Çarçak N,Onat F,Martin B,O'Brien TJ,Depaulis A,Jones NC

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The possibility that a recent seizure or a recent change in antiepileptic medication might produce an occult change in neuropsychological performance is of interest, and especially so in the context of evaluation for epilepsy surgery. Such an evaluation is often done in a setting of video-EEG monitoring where a...

journal_title：Epilepsia

authors： Dodrill CB,Ojemann GA

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Mesial temporal sclerosis (MTS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures. METHODS:We searched evidence for apoptotic cell death in temporal l...

journal_title：Epilepsia

authors： Uysal H,Cevik IU,Soylemezoglu F,Elibol B,Ozdemir YG,Evrenkaya T,Saygi S,Dalkara T

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To determine the lateralizing value of the clinical manifestations of seizures in patients with temporal lobe epilepsy (TLE), we made a retrospective videotape analysis of complex partial seizures (CPS) in 55 patients who underwent temporal lobectomy and were seizure-free postoperatively for >2 years. METHODS:...

journal_title：Epilepsia

authors： Marks WJ Jr,Laxer KD

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Appropriate treatment of generalized convulsive refractory status epilepticus (RSE) requires general anesthesia in the intensive care unit (ICU) with continuous electroencephalography (cEEG) monitoring. During out of office hours and weekends, cEEG monitoring is not always available. The Bispectral Index (BIS) ...

journal_title：Epilepsia

authors： Musialowicz T,Mervaala E,Kälviäinen R,Uusaro A,Ruokonen E,Parviainen I

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Refractory status epilepticus (RSE) is the persistence of seizure activity despite appropriate therapy; it is treated with high-dose suppressive anesthetic agents. We report here the outcome of RSE in a large series of children. METHODS:We retrospectively reviewed cases of RSE treated at Children's Hospital, B...

journal_title：Epilepsia

authors： Sahin M,Menache CC,Holmes GL,Riviello JJ

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Recent reports define temporal lobe epilepsy with amygdala enlargement (TLE-AE) as a distinct electroclinical syndrome comparable to TLE with hippocampal sclerosis. In this retrospective observational study, we present the largest consecutive series of patients with new-onset TLE-AE to date and describe clini...

journal_title：Epilepsia

authors： Malter MP,Widman G,Galldiks N,Stoecker W,Helmstaedter C,Elger CE,Wagner J

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States. METHODS:Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyze...

journal_title：Epilepsia

authors： Faught E,Laliberté F,Wang Z,Barghout V,Haider B,Lejeune D,Germain G,Choi J,Wagh A,Duh MS

更新日期：2017-10-01 00:00:00

abstract：:Impaired cortical inhibition may be involved in epileptogenic mechanisms. In a positron-emission tomography (PET) study, we demonstrated a reduction of the cortical benzodiazepine (BZD) receptor density in the epileptic foci of patients with partial epileptic seizures. In the present study, we used the same method in ...

journal_title：Epilepsia

authors： Savic I,Widen L,Thorell JO,Blomqvist G,Ericson K,Roland P

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:Pathogenic variants of KCNQ2, which encode a potassium channel subunit, cause either benign (familial) neonatal epilepsy-B(F)NE)-or KCNQ2 encephalopathy (KCNQ2 DEE). We examined the characteristics of KCNQ2 variants. METHODS:KCNQ2 pathogenic variants were collected from in-house data and two large disease da...

journal_title：Epilepsia

authors： Goto A,Ishii A,Shibata M,Ihara Y,Cooper EC,Hirose S

更新日期：2019-09-01 00:00:00

abstract：:The suppressive effect of sunglasses upon photoparoxysmal responses (PPRs) elicited by 15-Hz flicker stimuli with a low luminance of nearly 10 nits was studied in eight patients with photosensitive epilepsy. Using three commercially available sunglasses of neutral density (ND), blue, and brown, the influence upon gene...

journal_title：Epilepsia

authors： Takahashi T,Tsukahara Y

更新日期：1992-05-01 00:00:00

abstract：:Over 100 years ago, on the 27th of January 1881, Fyodor Mikhailovitch Dostoevsky died. Since that time, many biographies, monographs, memoirs, and, to a lesser extent, articles in the medical literature have discussed the fact that Dostoevsky was a patient with epilepsy. An attempt is made here to integrate the detail...

journal_title：Epilepsia

authors： Voskuil PH

更新日期：1983-12-01 00:00:00

abstract：:Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than sodium acetate; in each ...

journal_title：Epilepsia

authors： Colannino NM,Lipke H

更新日期：1983-10-01 00:00:00

abstract：PURPOSE:Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. METHODS:Repeated, low-dose (5 mg/kg), intraperito...

journal_title：Epilepsia

authors： Grabenstatter HL,Dudek FE

更新日期：2008-10-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rCRF) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. Such an effect was still present in rats neonatally treated with saline but was absent in...

journal_title：Epilepsia

authors： Marrosu F,Argiolas A,Carcangiu P,Giagheddu M,Fratta W

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To determine the cerebral electroencephalography (EEG) substrates of scalp EEG seizure patterns, such as source area and synchrony, and in so doing assess the limitations of scalp seizure recording in the localization of seizure onset zones in patients with temporal lobe epilepsy. METHODS:We recorded simultane...

journal_title：Epilepsia

authors： Tao JX,Baldwin M,Ray A,Hawes-Ebersole S,Ebersole JS

更新日期：2007-11-01 00:00:00

abstract：:The effects of carbamazepine (CBZ) monotherapy on serum sex hormone levels and on pituitary responsiveness to various stimuli were evaluated in a prospective study with 21 male patients with epilepsy. The serum levels of testosterone (T), free testosterone (FT), sex hormone binding globulin (SHBG), estradiol (E2), lut...

journal_title：Epilepsia

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1989-07-01 00:00:00

abstract：:The aim was to systematically review studies that have focused on symptoms of anxiety reported by parents of children (0-18 years) with epilepsy. PubMed was used to identify relevant studies. Selected studies were reviewed with respect to prevalence of above threshold scores and comparisons with controls on standardiz...

journal_title：Epilepsia

authors： Jones C,Reilly C

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical pictu...

journal_title：Epilepsia

authors： Schilling LP,Kieling RR,Pascoal TA,Kim HI,Lee MC,Kim YH,Paglioli E,Neto PR,Costa JC,Palmini A

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:We aimed to elucidate the mechanisms underlying video-game epilepsy by comparing the flicker- and spatial-frequency ranges over which photic and pattern stimulation elicited photoparoxysmal responses in two different populations: (a) 25 patients with a history of seizures experienced while playing video games; ...

journal_title：Epilepsia

authors： Fylan F,Harding GF,Edson AS,Webb RM

更新日期：1999-01-01 00:00:00

abstract：:We examined EEG findings from an ongoing study of 347 children with a first unprovoked seizure. EEGs were available in 321 (93%), and 135 (42%) had an abnormal EEG. EEG abnormalities included focal spikes (n = 77), generalized spike and wave discharges (n = 28), slowing (n = 43), and nonspecific abnormalities (n = 7)....

journal_title：Epilepsia

authors： Shinnar S,Kang H,Berg AT,Goldensohn ES,Hauser WA,Moshé SL

更新日期：1994-05-01 00:00:00

abstract：:A 28-year-old man with regularly occurring clusters of complex partial seizures was studied over a total of 224 days. His seizure periods lasted 2-4 days and occurred at intervals of 5-6 weeks. Several parameters were studied. The most striking finding was an increase in the serum concentration of thyroxine prior to a...

journal_title：Epilepsia

authors： Taubøll E,Stokke KT,Gjerstad L,Løyning Y,Johannessen SI

更新日期：1986-07-01 00:00:00

abstract：:Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

journal_title：Epilepsia

authors： Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

更新日期：2014-11-01 00:00:00

abstract：:The routine EEG study may prove inadequate in selected patients with recurrent and unprovoked seizures. Video-EEG monitoring is an important diagnostic innovation that may be used to confirm the diagnosis of a seizure disorder and classify seizure type. The methodologies and clinical applications of video-EEG monitori...

journal_title：Epilepsia

authors： Cascino GD

更新日期：2002-01-01 00:00:00

abstract：:We review information from large studies of defined populations, examining the role of known factors and especially of prenatal and perinatal factors in contributing to nonfebrile seizure disorders of early childhood. We depend especially, but not exclusively, on the recently completed analyses from the Collaborative ...

journal_title：Epilepsia

authors： Nelson KB,Ellenberg JH

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:This study examined the relation between psychiatric diagnosis and mental health services in children with epilepsy and the associated demographic, cognitive, linguistic, behavioral, and seizure-related variables. METHODS:The Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), the Child Behavio...

journal_title：Epilepsia

authors： Ott D,Siddarth P,Gurbani S,Koh S,Tournay A,Shields WD,Caplan R

更新日期：2003-04-01 00:00:00

abstract：:A case-control study of 305 children was done to evaluate the relationship between toxocariasis and seizures and risk factors associated with toxocariasis transmission and seizure onset. A significant association existed between seropositivity for anti-Toxocara canis and seizures (p less than 0.05); the correlation wa...

journal_title：Epilepsia

authors： Arpino C,Gattinara GC,Piergili D,Curatolo P

更新日期：1990-01-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：:Quantitative evidence of hippocampal atrophy has been correlated with site of seizure onset, hippocampal neuronal loss, and seizure relief after resection. Most studies have quantified hippocampal atrophy using ratios or differences between right and left hippocampal values. However, bilateral hippocampal atrophy may ...

journal_title：Epilepsia

authors： King D,Spencer SS,McCarthy G,Luby M,Spencer DD

更新日期：1995-09-01 00:00:00