The natural history of epilepsy in tuberous sclerosis complex.

abstract：:We report the history of a 14-year-old girl with atypical childhood occipital epilepsy "Gastaut type" whose first generalized tonic-clonic seizure was preceded by migraine without aura and followed by a status migrainosus. This status lasted for 3 days despite standard analgesic therapy. An EEG recording revealed an o...

journal_title：Epilepsia

authors： Parisi P,Kasteleijn-Nolst Trenité DG,Piccioli M,Pelliccia A,Luchetti A,Buttinelli C,Villa MP

更新日期：2007-11-01 00:00:00

abstract：:Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote histor...

journal_title：Epilepsia

authors： Chugani HT,Shewmon DA,Shields WD,Sankar R,Comair Y,Vinters HV,Peacock WJ

更新日期：1993-07-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：:We examined the relationship between clinical characteristics and EEG classification in all children with febrile seizures examined at the University Pediatric Clinic, Skopje, Yugoslavia between 1982 and 1984. This is the only facility in Macedonia providing EEG or neurologic consultation for children. EEGs were class...

journal_title：Epilepsia

authors： Sofijanov N,Emoto S,Kuturec M,Dukovski M,Duma F,Ellenberg JH,Hirtz DG,Nelson KB

更新日期：1992-01-01 00:00:00

abstract：UNLABELLED:Low-pressure hydrocephalic state (LPHS) has only recently been described as a distinct clinical entity occurring in patients with bioatrophic lesions of the brain. We report a patient in whom this syndrome developed after subtotal hemispherectomy for intractable epilepsy. METHODS:A 30-year-old man developed...

journal_title：Epilepsia

authors： Daniel RT,Lee GY,Halcrow SJ

更新日期：2002-05-01 00:00:00

abstract：:Monotherapy is the policy for management of patients with epilepsy. With increasing knowledge of the biology of epilepsy and of the modes of action of antiepileptic drugs (AEDs), this concept must be reevaluated. When monotherapy fails to control seizures, subsequent treatment should be based on "rational pharmacology...

journal_title：Epilepsia

authors： de Bittencourt PR,Mazer S,Marcourakis T,Bigarella MM,Ferreira ZS,Mumford JP

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy. METHODS:Determination of acylcarnitines (including free carnitine and acylcarnitines from C2 to C18) in dried blood spot specimens using tandem-mass spectrometry. Longitudinal study of changes in acylcarnitines...

journal_title：Epilepsia

authors： Werner T,Treiss I,Kohlmueller D,Mehlem P,Teich M,Longin E,Gerstner T,Koenig SA,Schulze A

更新日期：2007-01-01 00:00:00

abstract：:The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed. This diagnostic test, originally designed to distinguish a mechanism of primary from that of secondary bilateral synchrony in the EEG was al...

journal_title：Epilepsia

authors： Gloor P,Rasmussen T,Altuzarra A,Garretson H

更新日期：1976-03-01 00:00:00

abstract：PURPOSE:We aimed to elucidate the mechanisms underlying video-game epilepsy by comparing the flicker- and spatial-frequency ranges over which photic and pattern stimulation elicited photoparoxysmal responses in two different populations: (a) 25 patients with a history of seizures experienced while playing video games; ...

journal_title：Epilepsia

authors： Fylan F,Harding GF,Edson AS,Webb RM

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：:Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-li...

journal_title：Epilepsia

authors： Fueta Y,Siniscalchi A,Tancredi V,Avoli M

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:Neuropsychological studies suggest frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy (JME). In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectrosc...

journal_title：Epilepsia

authors： Savic I,Lekvall A,Greitz D,Helms G

更新日期：2000-03-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：:In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of...

journal_title：Epilepsia

authors： Yacubian EM,Rosemberg S,Marie SK,Valério RM,Jorge CL,Cukiert A

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To investigate possible predictive factors for seizure control in a group of children and adults with low IQs (IQ, < or =70) who underwent resective surgery for intractable focal epilepsy and to study outcome with respect to seizures and neuropsychological functioning. We also studied psychosocial outcome in th...

journal_title：Epilepsia

authors： Bjørnaes H,Stabell KE,Heminghyt E,Røste GK,Bakke SJ

更新日期：2004-02-01 00:00:00

abstract：:The Commission on Classification and Terminology and the Commission on Epidemiology of the International League Against Epilepsy (ILAE) have charged a Task Force to revise concepts, definition, and classification of status epilepticus (SE). The proposed new definition of SE is as follows: Status epilepticus is a condi...

journal_title：Epilepsia

authors： Trinka E,Cock H,Hesdorffer D,Rossetti AO,Scheffer IE,Shinnar S,Shorvon S,Lowenstein DH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To determine whether methsuximide (MSM) affects lamotrigine (LTG) blood levels and whether any change is of clinical significance. METHODS:LTG serum levels in 16 patients taking MSM were compared with those before starting or after stopping the MSM. The 16 patients, (11 boys, five girls) were young people (mea...

journal_title：Epilepsia

authors： Besag FM,Berry DJ,Pool F

更新日期：2000-05-01 00:00:00

abstract：:Five-hundred twelve epileptic children were followed longitudinally for several years. The 2- and 4-year remission statuses at the latest examination were 50.6 and 44.2%, respectively. Dividing our sample into groups showing onset of seizures in infancy or at 2-3, 4-7, 8-10, or 11-14 years, the remission rates were as...

journal_title：Epilepsia

authors： Sofijanov NG

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation ...

journal_title：Epilepsia

authors： Szaflarski JP,Hughes C,Szaflarski M,Ficker DM,Cahill WT,Li M,Privitera MD

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. METHODS:In acute studies of anticonvulsant efficacy, the AEDs were administered via or...

journal_title：Epilepsia

authors： White HS,Franklin MR,Kupferberg HJ,Schmutz M,Stables JP,Wolf HH

更新日期：2008-07-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To determine if the clinical characteristics of nonepileptic seizures (NES) are different in children younger than 13 years age as compared to adolescents. METHODS:Retrospective review of medical records and video-EEGs (VEEG) of all patients with NES confirmed on VEEG monitoring was performed. RESULTS:Sixty-e...

journal_title：Epilepsia

authors： Patel H,Scott E,Dunn D,Garg B

更新日期：2007-11-01 00:00:00

abstract：:We compared zonisamide monotherapy (12 weeks) to carbamazepine monotherapy (12 weeks) after phenytoin baseline monotherapy (8 weeks) in an open crossover pilot study of eight adults with uncontrolled partial seizures. Zonisamide had definite antiepileptic activity in five subjects. In two of these, response to zonisam...

journal_title：Epilepsia

authors： Wilensky AJ,Friel PN,Ojemann LM,Dodrill CB,McCormick KB,Levy RH

更新日期：1985-05-01 00:00:00

abstract：:A case-control study of 305 children was done to evaluate the relationship between toxocariasis and seizures and risk factors associated with toxocariasis transmission and seizure onset. A significant association existed between seropositivity for anti-Toxocara canis and seizures (p less than 0.05); the correlation wa...

journal_title：Epilepsia

authors： Arpino C,Gattinara GC,Piergili D,Curatolo P

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The multidrug resistance (mdr) gene family encodes the drug transport macromolecule P-glycoprotein (P-gp), which contributes to the functionality of the blood-brain barrier. Recent evidence suggests that P-gp-mediated drug extrusion may play a facilitatory role in refractory epilepsy. We investigated the region...

journal_title：Epilepsia

authors： Kwan P,Sills GJ,Butler E,Gant TW,Meldrum BS,Brodie MJ

更新日期：2002-11-01 00:00:00

abstract：:Some investigators argue that treating epilepsy with several antiepileptic drugs (AEDs) simultaneously (polytherapy) may give rise to more adverse effects than monotherapy, but this argument lacks supporting quantitative data. To reexamine this issue, we recruited a cohort of patients from the outpatients of the Speci...

journal_title：Epilepsia

authors： Lammers MW,Hekster YA,Keyser A,Meinardi H,Renier WO,van Lier H

更新日期：1995-05-01 00:00:00

abstract：:Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...

journal_title：Epilepsia

authors： Mitra J,Snider RS

更新日期：1975-06-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00