Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure.

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...

journal_title：Epilepsia

authors： Tran TA,Spencer SS,Javidan M,Pacia S,Marks D,Spencer DD

更新日期：1997-10-01 00:00:00

abstract：:Dogs with spontaneous diseases can exhibit a striking similarity in etiology, clinical manifestation, and disease course when compared to human patients. Therefore, dogs are intensely discussed as a translational model of human disease. In particular, genetic studies in selected dog breeds serve as an excellent tool t...

journal_title：Epilepsia

authors： Potschka H,Fischer A,von Rüden EL,Hülsmeyer V,Baumgärtner W

更新日期：2013-04-01 00:00:00

abstract：:Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-li...

journal_title：Epilepsia

authors： Fueta Y,Siniscalchi A,Tancredi V,Avoli M

更新日期：1995-04-01 00:00:00

abstract：:We determined the incidence of seizures due to acute CNS insults for residents of Rochester, Minnesota, U.S.A., from 1935 through 1984. The age-adjusted incidence rates for 1955-1984, the period of most complete case ascertainment, was 39.0/100,000 person-years (United States 1970 population as standard). The age-adju...

journal_title：Epilepsia

authors： Annegers JF,Hauser WA,Lee JR,Rocca WA

更新日期：1995-04-01 00:00:00

abstract：:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-04-01 00:00:00

abstract：:Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...

journal_title：Epilepsia

authors： Reid AY,Riazi K,Campbell Teskey G,Pittman QJ

更新日期：2013-04-01 00:00:00

abstract：:Cinromide (BW-122U) was evaluated in an open pilot study of absence seizures in three naive (previously untreated for absence seizures) patients (one male and two females, 7 to 8 years of age). In these naive patients, cinromide was found to be well tolerated but ineffective in reducing generalized spike-and-wave disc...

journal_title：Epilepsia

authors： Corwin HM,Dreifuss FE

更新日期：1983-08-01 00:00:00

abstract：:The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiep...

journal_title：Epilepsia

authors： Wheless JW,Treiman DM

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when converting to eslicarbazepine acetate (ESL), using data pooled from 2 ...

journal_title：Epilepsia

authors： Pazdera L,Sperling MR,Harvey JH,Sam MC,Strom LA,Blum D,Grinnell T,Cheng H

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Evidence for a poor psychiatric, social, and vocational adult outcome in childhood absence epilepsy (CAE) suggests long-term unmet mental health, social, and vocational needs. This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in childre...

journal_title：Epilepsia

authors： Caplan R,Siddarth P,Stahl L,Lanphier E,Vona P,Gurbani S,Koh S,Sankar R,Shields WD

更新日期：2008-11-01 00:00:00

abstract：:Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...

journal_title：Epilepsia

authors： Faught E

更新日期：2001-01-01 00:00:00

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：:Development of new excitatory connectivity and decreases in γ-aminobutyric acid (GABA)ergic inhibition are mechanisms underlying posttraumatic epileptogenesis in animal models. Experimental strategies that interfere with these processes, applied between the trauma and seizure onset, are antiepileptogenic in the labora...

journal_title：Epilepsia

authors： Prince DA,Parada I,Li H,McDonald W,Graber K

更新日期：2010-12-01 00:00:00

abstract：:In patients with pharmacoresistant focal epilepsy,we demonstrate that magnetoencephalography (MEG) detects spike-locked and spike-independent epileptic high gamma oscillations (HGOs) using combined MEG and invasive electroencephalography (iEEG) from subdural macroelectrodes. Six patients, who underwent presurgical wor...

journal_title：Epilepsia

authors： Rampp S,Kaltenhäuser M,Weigel D,Buchfelder M,Ingmar Blümcke I,Dörfler A,Stefan H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (...

journal_title：Epilepsia

authors： Foldvary-Schaefer N,De Leon Sanchez I,Karafa M,Mascha E,Dinner D,Morris HH

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Glutamate-gated N-methyl-d-aspartate receptors (NMDARs) are instrumental to brain development and functioning. Defects in the GRIN2A gene, encoding the GluN2A subunit of NMDARs, cause slow-wave sleep (SWS)-related disorders of the epilepsy-aphasia spectrum (EAS). The as-yet poorly understood developmental seq...

journal_title：Epilepsia

authors： Salmi M,Del Gallo F,Minlebaev M,Zakharov A,Pauly V,Perron P,Pons-Bennaceur A,Corby-Pellegrino S,Aniksztejn L,Lenck-Santini PP,Epsztein J,Khazipov R,Burnashev N,Bertini G,Szepetowski P

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:The low glycemic index treatment (LGIT) is a high fat, limited carbohydrate diet used in the treatment of epilepsy. The purpose of this study was to assess the efficacy and tolerability of the LGIT for the treatment of refractory seizures in pediatric patients with Angelman syndrome. METHODS:A pediatric Angelm...

journal_title：Epilepsia

authors： Thibert RL,Pfeifer HH,Larson AM,Raby AR,Reynolds AA,Morgan AK,Thiele EA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...

journal_title：Epilepsia

authors： Lin Y,Harris DA,Curry DJ,Lam S

更新日期：2015-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

journal_title：Epilepsia

authors： Muhlhofer W,Tan YL,Mueller SG,Knowlton R

更新日期：2017-05-01 00:00:00

abstract：:A 60-year-old patient had a 3-year history of recurrent memory disturbances. The video electroencephalographic (EEG) recording of one attack showed that the amnesic state, which clinically resembled transient global amnesia, was characterized by a normal EEG tracing followed by electroclinical complex partial seizures...

journal_title：Epilepsia

authors： Tassinari CA,Ciarmatori C,Alesi C,Cardinaletti L,Salvi F,Rubboli G,Plasmati R,Forti A,Michelucci R

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. METHODS:Repeated, low-dose (5 mg/kg), intraperito...

journal_title：Epilepsia

authors： Grabenstatter HL,Dudek FE

更新日期：2008-10-01 00:00:00

abstract：:Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved. Recent clinical findings have indicated that focal cortical regions are involved during absence seizures. Cons...

journal_title：Epilepsia

authors： Polack PO,Charpier S

更新日期：2009-07-01 00:00:00

abstract：:West syndrome consists of infantile spasms, hypsarrhythmia, and developmental arrest. Most patients remain mentally retarded and many develop Lennox-Gastaut syndrome. Using homozygosity mapping followed by exome sequencing we identified an ST3GAL3 mutation in three infants with West syndrome. ST3GAL3 encodes a sialylt...

journal_title：Epilepsia

authors： Edvardson S,Baumann AM,Mühlenhoff M,Stephan O,Kuss AW,Shaag A,He L,Zenvirt S,Tanzi R,Gerardy-Schahn R,Elpeleg O

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...

journal_title：Epilepsia

authors： Strzelczyk A,Cenusa M,Bauer S,Hamer HM,Mothersill IW,Grunwald T,Hillenbrand B,Ebner A,Steinhoff BJ,Krämer G,Rosenow F

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Previously we demonstrated that L-(+)-beta-hydroxybutyrate (L-BHB), acetoacetate (ACA), acetone, and dibenzylamine (DBA) were anticonvulsant in an audiogenic seizure-susceptible model, and that DBA was a bioactive contaminant identified in commercial lots of L-BHB. In the present study, we asked whether these e...

journal_title：Epilepsia

authors： Donevan SD,White HS,Anderson GD,Rho JM

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To demonstrate the anatomic localization of the cortical sources of the interictal EEG activity in human idiopathic generalized epilepsy (IGE). METHODS:Multiple cortical and hippocampal sources of the interictal spontaneous EEG activity were investigated by low-resolution electromagnetic tomography in 15 untre...

journal_title：Epilepsia

authors： Clemens B,Bessenyei M,Piros P,Tóth M,Seress L,Kondákor I

更新日期：2007-05-01 00:00:00

abstract：:Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...

journal_title：Epilepsia

authors： Gilby KL,Crino P,McIntyre DC

更新日期：2007-01-01 00:00:00