Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrate.

abstract：OBJECTIVE:We report on a quantitative analysis of data from a study that acquired continuous long-term ambulatory human electroencephalography (EEG) data over extended periods. The objectives were to examine the seizure duration and interseizure interval (ISI), their relationship to each other, and the effect of these ...

journal_title：Epilepsia

authors： Cook MJ,Karoly PJ,Freestone DR,Himes D,Leyde K,Berkovic S,O'Brien T,Grayden DB,Boston R

更新日期：2016-03-01 00:00:00

abstract：:Ideal antiepileptic drugs (AEDs) are designed to stop seizures with limited central nervous system (CNS) side effects. However, CNS-related treatment-emergent adverse events (TEAEs) often occur in patients receiving AEDs. Topiramate (TPM) is an AED proven to be safe and effective as adjunctive treatment for epilepsy p...

journal_title：Epilepsia

authors： Tatum WO 4th,French JA,Faught E,Morris GL 3rd,Liporace J,Kanner A,Goff SL,Winters L,Fix A,PADS Investigators. Post-marketing antiepileptic drug survey.

更新日期：2001-09-01 00:00:00

abstract：:Forebrain seizures were kindled in rats by daily electrical stimulation of the amygdala. Genetically epilepsy-prone rats scoring 9 (GEPR-9s) on the seizure severity scale during audiogenic seizure (AGS) screening ("brainstem seizure-experienced") required fewer stimulations to achieve fully kindled seizures (forelimb ...

journal_title：Epilepsia

authors： Coffey LL,Reith ME,Chen NH,Mishra PK,Jobe PC

更新日期：1996-02-01 00:00:00

abstract：:In patients with epilepsy, improvement in seizure control with treatment of coexisting obstructive sleep apnea (OSA) has been reported, but there is lack of data on the effect of continuous positive airway pressure (CPAP) compliance on seizure control in these patients. We examined the variability in seizure frequency...

journal_title：Epilepsia

authors： Vendrame M,Auerbach S,Loddenkemper T,Kothare S,Montouris G

更新日期：2011-11-01 00:00:00

abstract：:A need for prevalence information emphasizing racial differences prompted a door-to-door survey of all residents of Copiah County, Mississippi. The fieldwork involved a complete census and an extensive screening questionnaire inquiring about diagnoses, signs, and symptoms of neurologic disease. Residents who lived in ...

journal_title：Epilepsia

authors： Haerer AF,Anderson DW,Schoenberg BS

更新日期：1986-01-01 00:00:00

abstract：:Generalized epilepsies are treatable with a number of antiepileptic drugs (AEDs) that are effective in different seizure types and epilepsy syndromes. The mechanisms of action of these AEDs are incompletely understood but include inhibition of low-threshold calcium currents and of voltage-gated sodium channels and fac...

journal_title：Epilepsia

authors： Berkovic SF

更新日期：1998-01-01 00:00:00

abstract：:Accurate identification of cortical malformations in children with epilepsy can be crucial for successful clinical management. Although standard head-coil magnetic resonance imaging (MRI) at 1.5 tesla (T) can be used to view the macrostructure of the brain, phased array technology at both 1.5 and 3T significantly impr...

journal_title：Epilepsia

authors： Grant PE

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Studies using magnetic resonance imaging have shown that reduced hippocampal volume is associated with a history of febrile seizures, the duration of epilepsy, and the number of generalized tonic-clonic seizures. It is uncertain whether these factors have the same influence on functional as on structural measur...

journal_title：Epilepsia

authors： Theodore WH,Kelley K,Toczek MT,Gaillard WD

更新日期：2004-03-01 00:00:00

abstract：:The kinetic profiles of diazepam (DZP) were investigated in plasma, erythrocytes, and discrete brain areas in the rat, and the effects of valproic acid (VPA), given as sodium valproate, on kinetic parameters were analyzed. The experiments were performed on two groups of rats treated daily for 15 days, the first receiv...

journal_title：Epilepsia

authors： Hariton C,Jadot G,Valli M,Mesdjian E,Mandel P

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To investigate further the membrane properties and postsynaptic potentials of the CA3 pyramidal cells in mice that display spontaneous seizures because of a targeted deletion of the Kcna1 potassium channel gene (encoding the Kv1.1 protein subunit). METHODS:Intracellular recordings were obtained from CA3 pyrami...

journal_title：Epilepsia

authors： Lopantsev V,Tempel BL,Schwartzkroin PA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Sex differences are evident in the antiseizure activity of neurosteroids; however, the potential mechanisms remain unclear. In this study, we sought to determine whether differences in target extrasynaptic δ-subunit γ-aminobutyric acid type A (GABA-A) receptor expression and function underlie the sex differen...

journal_title：Epilepsia

authors： Reddy DS,Carver CM,Clossen B,Wu X

更新日期：2019-04-01 00:00:00

abstract：:We explored Kentuckians' attitudes toward children with epilepsy. Questions compared respondents' attitudes about children with epilepsy, asthma, hyperactivity, and AIDS. Random digit dialing led to 617 completed interviews. The key questions asked concerned (a) how a pupil with each illness would alter the classroom ...

journal_title：Epilepsia

authors： Baumann RJ,Wilson JF,Wiese HJ

更新日期：1995-10-01 00:00:00

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:In temporal lobe epilepsy (TLE), the thalamus is well known for its role in the propagation and spread of epileptiform activity. However, the integrity of thalamocortical functional connectivity (FC) in TLE and its relation to specific seizure patterns have not yet been determined. We address these issues wit...

journal_title：Epilepsia

authors： He X,Doucet GE,Sperling M,Sharan A,Tracy JI

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. METHODS:A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical I...

journal_title：Epilepsia

authors： Mady MA,Kossoff EH,McGregor AL,Wheless JW,Pyzik PL,Freeman JM

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is more common in children than adults and has a high mortality and morbidity rate. SE in adult rats results in long-term disturbances in learning and memory, as well as an enhanced seizure susceptibility to further seizures. In contrast, a number of studies suggest that the immature bra...

journal_title：Epilepsia

authors： Cilio MR,Sogawa Y,Cha BH,Liu X,Huang LT,Holmes GL

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To validate a brief screening instrument for identifying people with epilepsy in epidemiologic or genetic studies. METHODS:We designed a nine-question screening instrument for epilepsy and administered it by telephone to individuals with medical record-documented epilepsy (lifetime history of >or=2 unprovoked ...

journal_title：Epilepsia

authors： Ottman R,Barker-Cummings C,Leibson CL,Vasoli VM,Hauser WA,Buchhalter JR

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of vigabatrin (VGB) in the treatment of infantile spasms (ISs) associated with Down syndrome (DS) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. METHODS:Five children with ISs with DS were treated with vigabatrin as first-line monotherap...

journal_title：Epilepsia

authors： Nabbout R,Melki I,Gerbaka B,Dulac O,Akatcherian C

更新日期：2001-12-01 00:00:00

abstract：:The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...

journal_title：Epilepsia

authors： Annegers JF,Baumgartner KB,Hauser WA,Kurland LT

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：:Electrical stimulation of the visual cortex evoked the cortical focal seizure restricted in the neighbor cortex of the stimulated area in gallamine-immobilized cats. The present experiment was performed to clarify the participation of anticonvulsants in the cortex itself. Phenytoin and carbamazepine depressed the foca...

journal_title：Epilepsia

authors： Ito T,Hori M,Yoshida K,Shimizu M

更新日期：1977-03-01 00:00:00

abstract：:Surgical techniques may vary extensively between centers. We report on a web-based survey aimed at evaluating the current technical approaches in different centers around the world performing epilepsy surgery in children. The intention of the survey was to establish technical standards. A request was made to 88 center...

journal_title：Epilepsia

authors： Cukiert A,Rydenhag B,Harkness W,Cross JH,Gaillard WD,Task Force for Pediatric Epilepsy Surgery for the ILAE Commissions of Pediatrics and Surgical Therapies.

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures. It is known that metabolic crises in affected patients are precipitated by infections. Although growing evidence supports that inflammation facilitates sei...

journal_title：Epilepsia

authors： Salvadori MG,Banderó CR,Jesse AC,Gomes AT,Rambo LM,Bueno LM,Bortoluzzi VT,Oliveira MS,Mello CF

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To identify the timelines of magnetic resonance imaging (MRI) abnormalities and their relationships with the clinical outcomes of patients with new-onset refractory status epilepticus (NORSE). METHODS:This retrospective observational study enrolled patients with NORSE who were admitted from March 2008 to Jul...

journal_title：Epilepsia

authors： Kim HJ,Lee SA,Kim HW,Kim SJ,Jeon SB,Koo YS

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:We aimed to elucidate the mechanisms underlying video-game epilepsy by comparing the flicker- and spatial-frequency ranges over which photic and pattern stimulation elicited photoparoxysmal responses in two different populations: (a) 25 patients with a history of seizures experienced while playing video games; ...

journal_title：Epilepsia

authors： Fylan F,Harding GF,Edson AS,Webb RM

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Children with epilepsy have high rates of behavior problems. The purpose was to describe prospectively the association of seizures and behavior problems in children with new-onset seizures. METHODS:Subjects were 224 children with new-onset seizures (aged 4-14 years) and 159 siblings (4-18 years). Caregiver's r...

journal_title：Epilepsia

authors： Austin JK,Dunn DW,Caffrey HM,Perkins SM,Harezlak J,Rose DF

更新日期：2002-12-01 00:00:00

abstract：:The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs...

journal_title：Epilepsia

authors： Coutinho-Netto J,Boyar MM,Abdul-Ghani AS,Bradford HF

更新日期：1982-08-01 00:00:00

abstract：:Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

journal_title：Epilepsia

authors： Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:Self-management challenges facing adults with epilepsy include limited understanding of the condition and treatment, associated psychosocial issues, and lack of community integration. Self-management interventions improve patients' medical, life role, and emotional management. Previous interventions, develope...

journal_title：Epilepsia

authors： Fraser RT,Johnson EK,Lashley S,Barber J,Chaytor N,Miller JW,Ciechanowski P,Temkin N,Caylor L

更新日期：2015-08-01 00:00:00