Abstract:
SUMMARY:Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries. Meta-analyses of randomized controlled trials suggest that few differences in efficacy exist between PB and other established AEDs, but its possible deleterious cognitive and behavioral side effects remain a concern in the developed world. In contrast, high degrees of efficacy and tolerability in everyday clinical use have been demonstrated consistently in observational studies in developing countries. We propose that a pragmatic, comprehensive outcomes program be carried out, perhaps under the aegis of the Global Campaign Against Epilepsy, to optimize the conditions of the use of PB, so that more people around the world can benefit from this cost-effective medication and live more fulfilling lives.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Kwan P,Brodie MJdoi
10.1111/j.0013-9580.2004.12704.xsubject
Has Abstractpub_date
2004-09-01 00:00:00pages
1141-9issue
9eissn
0013-9580issn
1528-1167pii
EPI12704journal_volume
45pub_type
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