Early-onset benign occipital seizure susceptibility syndrome.

abstract：PURPOSE:To identify and define clinical and behavioral features of patients with adult-onset idiopathic generalized epilepsy (IGE). METHODS:We reviewed the charts of 313 IGE patients at the NYU Comprehensive Epilepsy Center over the past 5 years to identify patients with adult onset (18 years old or older). We exclude...

journal_title：Epilepsia

authors： Cutting S,Lauchheimer A,Barr W,Devinsky O

更新日期：2001-11-01 00:00:00

abstract：:Impaired cortical inhibition may be involved in epileptogenic mechanisms. In a positron-emission tomography (PET) study, we demonstrated a reduction of the cortical benzodiazepine (BZD) receptor density in the epileptic foci of patients with partial epileptic seizures. In the present study, we used the same method in ...

journal_title：Epilepsia

authors： Savic I,Widen L,Thorell JO,Blomqvist G,Ericson K,Roland P

更新日期：1990-11-01 00:00:00

abstract：:The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...

journal_title：Epilepsia

authors： Annegers JF,Baumgartner KB,Hauser WA,Kurland LT

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS:Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: p...

journal_title：Epilepsia

authors： Shin DS,Yu W,Sutton A,Calos M,Puil E,Carlen PL

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The annual prevalence of antiepileptic drug (AED) prescribing reported in the literature differs considerably among European countries due to use of different type of data sources, time periods, population distribution, and methodologic differences. This study aimed to measure prevalence of AED prescribing ac...

journal_title：Epilepsia

authors： de Groot MC,Schuerch M,de Vries F,Hesse U,Oliva B,Gil M,Huerta C,Requena G,de Abajo F,Afonso AS,Souverein PC,Alvarez Y,Slattery J,Rottenkolber M,Schmiedl S,Van Dijk L,Schlienger RG,Reynolds R,Klungel OH

更新日期：2014-05-01 00:00:00

abstract：:The blood-brain barrier, a unique feature of the cerebral vasculature, is gaining attention as a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy, and schizophrenia. Although acute blood-brain barrier dysfunction can induce cerebral edema, seizures, or neuropsychiatric symptoms...

journal_title：Epilepsia

authors： Schoknecht K,Shalev H

更新日期：2012-11-01 00:00:00

abstract：:The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h prein...

journal_title：Epilepsia

authors： Chen SS,Shen MR,Chen TJ,Lai SL

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Bone disease and fractures are common with chronic antiepileptic drug (AED) therapy, but the underlying mechanisms are poorly understood. This study aimed to characterize adverse bone effects of valproate and to identify mouse strains either resistant or sensitive to these effects. METHODS:Seven mouse strains ...

journal_title：Epilepsia

authors： Senn SM,Kantor S,Poulton IJ,Morris MJ,Sims NA,O'Brien TJ,Wark JD

更新日期：2010-06-01 00:00:00

abstract：:Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...

journal_title：Epilepsia

authors： Mitra J,Snider RS

更新日期：1975-06-01 00:00:00

abstract：:A 60-year-old patient had a 3-year history of recurrent memory disturbances. The video electroencephalographic (EEG) recording of one attack showed that the amnesic state, which clinically resembled transient global amnesia, was characterized by a normal EEG tracing followed by electroclinical complex partial seizures...

journal_title：Epilepsia

authors： Tassinari CA,Ciarmatori C,Alesi C,Cardinaletti L,Salvi F,Rubboli G,Plasmati R,Forti A,Michelucci R

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:To investigate further the membrane properties and postsynaptic potentials of the CA3 pyramidal cells in mice that display spontaneous seizures because of a targeted deletion of the Kcna1 potassium channel gene (encoding the Kv1.1 protein subunit). METHODS:Intracellular recordings were obtained from CA3 pyrami...

journal_title：Epilepsia

authors： Lopantsev V,Tempel BL,Schwartzkroin PA

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS:We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic co...

journal_title：Epilepsia

authors： Beleza P,Bilgin O,Noachtar S

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The presence of specific neurocognitive deficits may help explain why school achievement and psychosocial functioning are often worse in children with epilepsy than would be predicted by their global intellectual functioning. This study compared children with two forms of epilepsy: localization-related epilepsy...

journal_title：Epilepsia

authors： Kernan CL,Asarnow R,Siddarth P,Gurbani S,Lanphier EK,Sankar R,Caplan R

更新日期：2012-12-01 00:00:00

abstract：:Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor (dissociation constant, KD, of 3 nM) linked to the GABAA recognition site enhances the inhibitory action of GABA by increasing the number of openings of Cl- ch...

journal_title：Epilepsia

authors： Meldrum BS,Chapman AG

更新日期：1986-01-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Guidelines recommend that encephalopathic critically ill children undergo continuous electroencephalographic (CEEG) monitoring for electrographic seizure (ES) identification and management. However, limited data exist on antiseizure medication (ASM) safety for ES treatment in critically ill children. METHODS...

journal_title：Epilepsia

authors： Fung FW,Jacobwitz M,Vala L,Parikh D,Donnelly M,Xiao R,Topjian AA,Abend NS

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...

journal_title：Epilepsia

authors： Leary LD,Wang D,Nordli DR Jr,Engelstad K,De Vivo DC

更新日期：2003-05-01 00:00:00

abstract：:Between 1929 and 1980, 284 patients with refractory nontumoral frontal lobe epilepsy (FLE) underwent operation at the Montreal Neurological Institute (MNI). We studied 39 patients (14%) who required reoperation. Mean age at the time of first operation was 18 years and at reoperation was 22 years. Clinical manifestatio...

journal_title：Epilepsia

authors： Salanova V,Quesney LF,Rasmussen T,Andermann F,Olivier A

更新日期：1994-01-01 00:00:00

abstract：:The epilepsy community increasingly recognizes the need for a modern classification system that can also be easily integrated with effective informatics tools. The 2010 reports by the United States President's Council of Advisors on Science and Technology (PCAST) identified informatics as a critical resource to improv...

journal_title：Epilepsia

authors： Sahoo SS,Zhang GQ,Lhatoo SD

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Nitric oxide (NO), a short-lived radical synthesized from L-arginine by activation of the enzyme nitric oxide synthase (NOS), has been implicated in the pathophysiology of epilepsy by some investigators. However, the current data about NO and NOS in epilepsy are controversial and are derived only from animal mo...

journal_title：Epilepsia

authors： González-Hernández T,García-Marín V,Pérez-Delgado MM,González-González ML,Rancel-Torres N,González-Feria L

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to systematically review the literature on the interictal language profile in adult patients with epilepsy. METHODS:An extensive literature search was performed using MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, PASCAL, and PSYNDEXplus databases. Ke...

journal_title：Epilepsia

authors： Bartha-Doering L,Trinka E

更新日期：2014-10-01 00:00:00

abstract：:In this study, we aimed to investigate the types of seizures and epilepsy associated with systemic lupus erythematosus (SLE). We searched the medical records at a tertiary referral center to identify a cohort of epilepsy patients with SLE who were treated between January 2000 and August 2011. We analyzed the clinical ...

journal_title：Epilepsia

authors： Toyota T,Akamatsu N,Tanaka A,Shouzaki T,Tsuji S,Saito K,Tanaka Y

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...

journal_title：Epilepsia

authors： Nail-Boucherie K,Lê-Pham BT,Gobaille S,Maitre M,Aunis D,Depaulis A

更新日期：2005-01-01 00:00:00

abstract：:ACC-9653, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin, is a prodrug of phenytoin with advantageous physicochemical properties. ACC-9653 is rapidly converted enzymatically to phenytoin in vivo. ACC-9653 and phenytoin sodium have equivalent anticonvulsant activity against seizures induced by ma...

journal_title：Epilepsia

authors： Smith RD,Brown BS,Maher RW,Matier WL

更新日期：1989-01-01 00:00:00

abstract：:The Commission on Classification and Terminology and the Commission on Epidemiology of the International League Against Epilepsy (ILAE) have charged a Task Force to revise concepts, definition, and classification of status epilepticus (SE). The proposed new definition of SE is as follows: Status epilepticus is a condi...

journal_title：Epilepsia

authors： Trinka E,Cock H,Hesdorffer D,Rossetti AO,Scheffer IE,Shinnar S,Shorvon S,Lowenstein DH

更新日期：2015-10-01 00:00:00

abstract：:The distribution of seizure types was investigated in an epidemiological survey of 1,220 patients over 15 years of age. Classification of clinically dominant seizure type according to the International Classification of Epileptic Seizures (ICES) was possible in 1,005 cases (82.5%). Fifty-six percent of patients had pa...

journal_title：Epilepsia

authors： Keränen T,Sillanpää M,Riekkinen PJ

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:There are limited data on the indications for the use of chronic invasive electroencephalography (EEG) monitoring (IEM) for pediatric epilepsy surgery. METHODS:We retrospectively studied 102 children who underwent intracranial monitoring to map critical cortex, localize the epileptogenic region, or resolve d...

journal_title：Epilepsia

authors： Brna P,Duchowny M,Resnick T,Dunoyer C,Bhatia S,Jayakar P

更新日期：2015-07-01 00:00:00

abstract：:Surgical techniques may vary extensively between centers. We report on a web-based survey aimed at evaluating the current technical approaches in different centers around the world performing epilepsy surgery in children. The intention of the survey was to establish technical standards. A request was made to 88 center...

journal_title：Epilepsia

authors： Cukiert A,Rydenhag B,Harkness W,Cross JH,Gaillard WD,Task Force for Pediatric Epilepsy Surgery for the ILAE Commissions of Pediatrics and Surgical Therapies.

更新日期：2016-02-01 00:00:00