Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.

abstract：OBJECTIVE:Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether...

journal_title：Epilepsia

authors： Taraschenko O,Fox HS,Pittock SJ,Zekeridou A,Gafurova M,Eldridge E,Liu J,Dravid SM,Dingledine R

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subsequent FS. METHODS:Cases included a first FS that was FSE drawn fr...

journal_title：Epilepsia

authors： Hesdorffer DC,Shinnar S,Lax DN,Pellock JM,Nordli DR Jr,Seinfeld S,Gallentine W,Frank LM,Lewis DV,Shinnar RC,Bello JA,Chan S,Epstein LG,Moshé SL,Liu B,Sun S,FEBSTAT study team.

更新日期：2016-07-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To describe the behavioral and EEG topographic correlates of absences with 3-Hz generalized spike-waves and partitioned impairment of consciousness. METHODS:Two adult women had so-called "phantom" absences, characterized by brief and mild impairments of consciousness that were previously inconspicuous to both ...

journal_title：Epilepsia

authors： Vuilleumier P,Assal F,Blanke O,Jallon P

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...

journal_title：Epilepsia

authors： Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To describe the long-term outcome of childhood-onset secondarily generalized epilepsies (SGEs). METHODS:Children were identified from the Nova Scotia population-based epilepsy study (n=692). Onset of epilepsy was between 1977 and 1985, and follow-up was mainly in 2003. SGE was defined as having a mixture of mo...

journal_title：Epilepsia

authors： Camfield P,Camfield C

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To review the clinical, neurophysiologic, and radiological data of patients with ganglioglioma who had undergone evaluation and surgery in our Epilepsy Program. METHODS:The medical and neurophysiologic records of 38 patients with intractable epilepsy and ganglioglioma were reviewed. Data underwent statistical ...

journal_title：Epilepsia

authors： Morris HH,Matkovic Z,Estes ML,Prayson RA,Comair YG,Turnbull J,Najm I,Kotagal P,Wyllie E

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:Because the capacity of intracarotid amobarbital (Wada) memory assessment to predict seizure-onset laterality in children has not been thoroughly investigated, three comprehensive epilepsy surgery centers pooled their data and examined Wada memory asymmetries to predict side of seizure onset in children being c...

journal_title：Epilepsia

authors： Lee GP,Park YD,Hempel A,Westerveld M,Loring DW

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide ...

journal_title：Epilepsia

authors： Mula M,McGonigal A,Micoulaud-Franchi JA,May TW,Labudda K,Brandt C

更新日期：2016-06-01 00:00:00

abstract：:Parenteral magnesium sulfate has been used to control acute convulsions of diverse etiologies and is currently a mainstay in controlling eclamptic convulsions. However, the site of this anticonvulsant action has remained controversial and not well studied in experimental epileptic models. Therefore we determined the e...

journal_title：Epilepsia

authors： Borges LF,Gücer G

更新日期：1978-02-01 00:00:00

abstract：:This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age of a planned transition of adolesce...

journal_title：Epilepsia

authors： Camfield CS,Berg A,Stephani U,Wirrell EC

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：:We explored Kentuckians' attitudes toward children with epilepsy. Questions compared respondents' attitudes about children with epilepsy, asthma, hyperactivity, and AIDS. Random digit dialing led to 617 completed interviews. The key questions asked concerned (a) how a pupil with each illness would alter the classroom ...

journal_title：Epilepsia

authors： Baumann RJ,Wilson JF,Wiese HJ

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...

journal_title：Epilepsia

authors： Powell KL,Tang H,Ng C,Guillemain I,Dieuset G,Dezsi G,Çarçak N,Onat F,Martin B,O'Brien TJ,Depaulis A,Jones NC

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, and comparative pharmacokinetics (PK) of intravenous and oral carbamazepine. METHODS:In this phase 1, open-label study, adult patients with epilepsy on a stable oral carbamazepine dosage (400-2,000 mg/day) were converted to intravenous carbamazepine (administered at 70% ...

journal_title：Epilepsia

authors： Tolbert D,Cloyd J,Biton V,Bekersky I,Walzer M,Wesche D,Drummond R,Lee D

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Previous studies have established the importance of the insular cortex and temporal lobe in cardiovascular autonomic modulation. Some investigators, based on the results of cortical stimulation response, functional imaging, EEG recordings of seizures, and lesional studies, have suggested that cardiac sympatheti...

journal_title：Epilepsia

authors： Britton JW,Ghearing GR,Benarroch EE,Cascino GD

更新日期：2006-04-01 00:00:00

abstract：SUMMARY:Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries. Meta-analyses of randomized controlled trials suggest that few differences in efficacy exist between PB and other established AEDs, but its possible deleteri...

journal_title：Epilepsia

authors： Kwan P,Brodie MJ

更新日期：2004-09-01 00:00:00

abstract：:The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

journal_title：Epilepsia

authors： Offermann G,Pinto V,Kruse R

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are considered less favorable for open resection. METHODS:We retrospectively ...

journal_title：Epilepsia

authors： Gupta K,Cabaniss B,Kheder A,Gedela S,Koch P,Hewitt KC,Alwaki A,Rich C,Ramesha S,Hu R,Drane DL,Gross RE,Willie JT

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To evaluate the effect of stress on seizure frequency in childhood epilepsy, and to assess possible differences between children in whom seizures are precipitated by stress and those in whom they are not. METHODS:Parents or caregivers of children with active epilepsy (aged 2-16 years) were sent questionnaires ...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Steinbusch LC,Joëls M,Braun KP

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Transient hyperammonemia (THA) was reported to follow generalized convulsions without sufficient evidence to confirm the epileptic nature of those events. We aimed to determine if postictal THA can differentiate between different types of events as confirmed electroencephalographically using video-electroence...

journal_title：Epilepsia

authors： Albadareen R,Gronseth G,Landazuri P,He J,Hammond N,Uysal U

更新日期：2016-08-01 00:00:00

abstract：:The effects of carbamazepine (CBZ) monotherapy on serum sex hormone levels and on pituitary responsiveness to various stimuli were evaluated in a prospective study with 21 male patients with epilepsy. The serum levels of testosterone (T), free testosterone (FT), sex hormone binding globulin (SHBG), estradiol (E2), lut...

journal_title：Epilepsia

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

journal_title：Epilepsia

authors： Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

更新日期：2020-09-01 00:00:00

abstract：:The advent of social networking via the Internet and the commercial availability of tests for SCN1A mutations permitted the rapid development and growth of parent-led associations that provide advocacy and support, as well as promote education and research regarding Dravet syndrome (DS) in the last 10 years. The Inter...

journal_title：Epilepsia

authors： Skluzacek JV,Watts KP,Parsy O,Wical B,Camfield P

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:To confirm the efficacy and to clarify the problems of clobazam (CLB) as a new antiepileptic drug (AED) and clorazepate (CLP) as an alternative AED in Japan. METHODS:CLB and CLP were added on or replaced with conventional AEDs in 55 and 170 patients with refractory epilepsies, respectively. Short-term efficacy...

journal_title：Epilepsia

authors： Sugai K

更新日期：2004-01-01 00:00:00

abstract：:The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

journal_title：Epilepsia

authors： Goodman JH,Homan RW,Crawford IL

更新日期：1990-09-01 00:00:00

abstract：:Forebrain seizures were kindled in rats by daily electrical stimulation of the amygdala. Genetically epilepsy-prone rats scoring 9 (GEPR-9s) on the seizure severity scale during audiogenic seizure (AGS) screening ("brainstem seizure-experienced") required fewer stimulations to achieve fully kindled seizures (forelimb ...

journal_title：Epilepsia

authors： Coffey LL,Reith ME,Chen NH,Mishra PK,Jobe PC

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS:The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic dis...

journal_title：Epilepsia

authors： Jefferys JG

更新日期：2003-01-01 00:00:00

abstract：:Variants in the SCN2A gene, encoding the voltage-gated sodium channel NaV 1.2, cause a variety of neuropsychiatric syndromes with different severity ranging from self-limiting epilepsies with early onset to developmental and epileptic encephalopathy with early or late onset and intellectual disability (ID), as well as...

journal_title：Epilepsia

authors： Hedrich UBS,Lauxmann S,Lerche H

更新日期：2019-12-01 00:00:00