Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.

Abstract:

PURPOSE:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations of LH as well as circadian organization of ultradian bursts of LH. METHODS:We characterized LH secretion in 10 men with TLE during two 24-h blocks: an interictal epoch and a postictal epoch initiated by a seizure. Serum LH was measured every 10 min and characterized by circadian and ultradian patterns with cosinor and deconvolution analysis. RESULTS:Mean peak serum concentrations of LH occurred at approximately 0400 in controls, were significantly delayed approximately 5 h interictally, and were randomly distributed postictally. Burst amplitudes differed significantly by phase among controls, with the largest amplitudes between 0101 and 0700 and the smallest between 1301 and 1900. No phase differences were present in interictal or postictal epochs. Burst frequency weakly but significantly was slowest between 0101 and 0700 in controls, but did not differ significantly by phase in either interictal or postictal epochs. Postictal LH burst frequencies, but not amplitudes, were significantly decreased immediately postictally. CONCLUSION:The pulsatile secretion of LH in TLE is abnormal both in the circadian as well as the ultradian domain. Interictal effects consist mainly in loss of circadian fluctuations in LH burst amplitude, whereas postictal effects consist of altered burst timing. Altered daily patterns of neuroendocrine signals may underlie other disorders of homeostasis in TLE.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Quigg M,Kiely JM,Johnson ML,Straume M,Bertram EH,Evans WS

doi

10.1111/j.1528-1167.2006.00617.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1452-9

issue

9

eissn

0013-9580

issn

1528-1167

pii

EPI617

journal_volume

47

pub_type

杂志文章
  • Transient epileptic amnesia: an emerging late-onset epileptic syndrome.

    abstract::Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances. For many years this condition has been associated with the nonepileptic condition of transient global amnesia (TGA) and still...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2009.02124.x

    authors: Bilo L,Meo R,Ruosi P,de Leva MF,Striano S

    更新日期:2009-05-01 00:00:00

  • Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.

    abstract::The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13670

    authors: Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

    更新日期:2017-04-01 00:00:00

  • Muscarinic receptor loss and preservation of presynaptic cholinergic terminals in hippocampal sclerosis.

    abstract:PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb01986.x

    authors: Pennell PB,Burdette DE,Ross DA,Henry TR,Albin RL,Sackellares JC,Frey KA

    更新日期:1999-01-01 00:00:00

  • Epilepsy informatics and an ontology-driven infrastructure for large database research and patient care in epilepsy.

    abstract::The epilepsy community increasingly recognizes the need for a modern classification system that can also be easily integrated with effective informatics tools. The 2010 reports by the United States President's Council of Advisors on Science and Technology (PCAST) identified informatics as a critical resource to improv...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/epi.12211

    authors: Sahoo SS,Zhang GQ,Lhatoo SD

    更新日期:2013-08-01 00:00:00

  • The impact of cerebral source area and synchrony on recording scalp electroencephalography ictal patterns.

    abstract:PURPOSE:To determine the cerebral electroencephalography (EEG) substrates of scalp EEG seizure patterns, such as source area and synchrony, and in so doing assess the limitations of scalp seizure recording in the localization of seizure onset zones in patients with temporal lobe epilepsy. METHODS:We recorded simultane...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2007.01224.x

    authors: Tao JX,Baldwin M,Ray A,Hawes-Ebersole S,Ebersole JS

    更新日期:2007-11-01 00:00:00

  • MOSES: an educational program for patients with epilepsy and their relatives.

    abstract::The knowledge of patients with epilepsy about their own condition is poor, and thus the need for educational programs for people with epilepsy has long been recognized. However, no such programs have been established in their routine care. The Modular Service Package Epilepsy (MOSES) now tries to fill this gap for pat...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2001.042suppl.3076.x

    authors: Ried S,Specht U,Thorbecke R,Goecke K,Wohlfarth R

    更新日期:2001-01-01 00:00:00

  • First seizure: EEG and neuroimaging following an epileptic seizure.

    abstract::An early EEG (within 48 h) and high-resolution magnetic resonance imaging (hr_MRI) are the methods of choice for an accurate diagnosis after a first seizure presentation. Together with a careful history and examination, they will allow definition of the epilepsy syndrome in two-thirds of patients and help assess the i...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2008.01445.x

    authors: Pohlmann-Eden B,Newton M

    更新日期:2008-01-01 00:00:00

  • Cognitive, psychosocial, and family function one year after pediatric epilepsy surgery.

    abstract:PURPOSE:Assumptions regarding the benefits of seizure control after pediatric epilepsy surgery for cognitive, psychosocial, and family function were explored in a prospective study of 51 children with intractable epilepsy. METHODS:Thirty children who underwent surgery were studied before and 1 year after surgery, and ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.0013-9580.2004.21903.x

    authors: Smith ML,Elliott IM,Lach L

    更新日期:2004-06-01 00:00:00

  • Nuclear magnetic resonance relaxometry in a penicillin model of focal epilepsy.

    abstract::Magnetic resonance imaging (MRI) is effective in demonstrating pathologic lesions in patients with epilepsy. It has been suggested that MRI might also reveal functional abnormalities at an interictal epileptic focus when no gross structural change such as gliosis or tumor is present. Experimental epileptic foci were p...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1988.tb03737.x

    authors: McLachlan RS,Karlik SJ,Myles V

    更新日期:1988-07-01 00:00:00

  • Focal cortical dysplasia type IIb in the rolandic cortex: functional reorganization after early surgery documented by passive task functional MRI.

    abstract::Surgery for seizures arising from the rolandic area can be performed effectively, and accurate mapping of eloquent regions may improve seizure and functional outcome. Noninvasive cortical mapping is, however, hardly feasible in young children. We studied two children with epileptogenic focal cortical dysplasia (FCD) t...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2012.03524.x

    authors: Barba C,Montanaro D,Frijia F,Giordano F,Blümcke I,Genitori L,De Masi F,Guerrini R

    更新日期:2012-08-01 00:00:00

  • Fetal heart rate patterns and chronic exposure to antiepileptic drugs.

    abstract::Fetal heart rate (FHR) characteristics of fetuses exposed and not exposed to antiepileptic drugs (AEDs) were studied. FHR is considered to reflect central nervous system (CNS) integrity. Three intervals during pregnancy were investigated: 20, 32, and 38 weeks. At 32 and 38 weeks, FHR was studied in relation to quiet (...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1992.tb02353.x

    authors: Swartjes JM,van Geijn HP,Meinardi H,Mantel R

    更新日期:1992-07-01 00:00:00

  • Identifying the epileptogenic zone in interictal resting-state MEG source-space networks.

    abstract:OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13622

    authors: Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

    更新日期:2017-01-01 00:00:00

  • Clinical significance of nonhabitual seizures during intracranial EEG monitoring.

    abstract::This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12462

    authors: Kovac S,Rodionov R,Chinnasami S,Wehner T,Scott CA,McEvoy AW,Miserocchi A,Diehl B

    更新日期:2014-01-01 00:00:00

  • Lafora's disease in south India: a clinical, electrophysiologic, and pathologic study.

    abstract::Twenty-one cases (12 males, 9 females) of Lafora's disease in 16 families were studied at the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India, from 1982 to 1990. Mean age of onset was 13.5 years (range 9.5-18 years). First symptom was generalized tonic-clonic seizure (17), myoclonus ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1993.tb02588.x

    authors: Acharya JN,Satishchandra P,Asha T,Shankar SK

    更新日期:1993-05-01 00:00:00

  • Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.

    abstract:PURPOSE:With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mg/kg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder. METHODS:Experiments were performed in 12-, 18-, and 60-day...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb02006.x

    authors: Kábová R,Liptáková S,Slamberová R,Pometlová M,Velísek L

    更新日期:1999-10-01 00:00:00

  • The intracarotid amobarbital procedure: when is it worth repeating?

    abstract:PURPOSE:Despite the reported diagnostic value of the intracarotid amobarbital procedure (IAP) or "Wada test" for determining hemispheric lateralization and memory functioning, it has never undergone formal reliability testing because a prospective test-retest study design is neither feasible nor ethical. However, some ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03399.x

    authors: Whitman LA,Morrison CE,Becske T,Barr WB,Carlson C

    更新日期:2012-04-01 00:00:00

  • Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE.

    abstract::Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/epi.13909

    authors: Moyer JT,Gnatkovsky V,Ono T,Otáhal J,Wagenaar J,Stacey WC,Noebels J,Ikeda A,Staley K,de Curtis M,Litt B,Galanopoulou AS

    更新日期:2017-11-01 00:00:00

  • Lingual seizures.

    abstract::A 73-year-old patient with hyperglycemia and rheumatoid arthritis presented with attacks of involuntary lingual movements that were associated with pain at the base of the tongue, often followed by aversion of head and eyes to the left with clonic contractions of the left corner of the mouth. Seizures could be induced...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1988.tb05094.x

    authors: Neufeld MY,Blumen SC,Nisipeanu P,Korczyn AD

    更新日期:1988-01-01 00:00:00

  • Pediatric language mapping: sensitivity of neurostimulation and Wada testing in epilepsy surgery.

    abstract:PURPOSE:Functional mapping of eloquent cortex with electrical neurostimulation is used both intra- and extraoperatively to tailor resections. In pediatric patients, however, functional mapping studies frequently fail to localize language. Wada testing has also been reported to be less sensitive in children. METHODS:Th...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00962.x

    authors: Schevon CA,Carlson C,Zaroff CM,Weiner HJ,Doyle WK,Miles D,Lajoie J,Kuzniecky R,Pacia S,Vazquez B,Luciano D,Najjar S,Devinsky O

    更新日期:2007-03-01 00:00:00

  • Progressive myoclonus epilepsies: clinical and genetic aspects.

    abstract::The progressive myoclonus epilepsies (PMEs) are a group of rare genetic disorders previously shrouded in nosological confusion. Recent advances have clarified the features of these disorders and provided a rational approach to diagnosis. The major causes of PME are now known to be Unverricht-Lundborg disease, myoclonu...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.1993.tb06256.x

    authors: Berkovic SF,Cochius J,Andermann E,Andermann F

    更新日期:1993-01-01 00:00:00

  • Rational polypharmacy.

    abstract::The medical treatment of seizure disorders is a complex process, requiring extensive interaction and co-operation between physician and patient. The physician must have an accurate diagnosis of the patient's illness and a comprehensive understanding of seizures and seizure disorders. The physician must consider specif...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1157.1995.tb05994.x

    authors: Ferrendelli JA

    更新日期:1995-01-01 00:00:00

  • Retrospective multiinstitutional study of the prevalence of early death in Dravet syndrome.

    abstract:PURPOSE:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. METHODS:A questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1528-1167.2011.03053.x

    authors: Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

    更新日期:2011-06-01 00:00:00

  • Optimizing the molecular diagnosis of CDKL5 gene-related epileptic encephalopathy in boys.

    abstract:OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12803

    authors: Mei D,Darra F,Barba C,Marini C,Fontana E,Chiti L,Parrini E,Dalla Bernardina B,Guerrini R

    更新日期:2014-11-01 00:00:00

  • Technical aspects of pediatric epilepsy surgery: Report of a multicenter, multinational web-based survey by the ILAE Task Force on Pediatric Epilepsy Surgery.

    abstract::Surgical techniques may vary extensively between centers. We report on a web-based survey aimed at evaluating the current technical approaches in different centers around the world performing epilepsy surgery in children. The intention of the survey was to establish technical standards. A request was made to 88 center...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/epi.13292

    authors: Cukiert A,Rydenhag B,Harkness W,Cross JH,Gaillard WD,Task Force for Pediatric Epilepsy Surgery for the ILAE Commissions of Pediatrics and Surgical Therapies.

    更新日期:2016-02-01 00:00:00

  • Epileptic seizures in elderly patients with dementia.

    abstract::All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1992.tb02343.x

    authors: McAreavey MJ,Ballinger BR,Fenton GW

    更新日期:1992-07-01 00:00:00

  • The BOLD effect of interictal spike activity in childhood occipital lobe epilepsy.

    abstract:PURPOSE:Occipital lobe epilepsy (OLE) presents in childhood with different manifestations, age of onset and EEG features that form distinct syndromes. The ictal clinical symptoms are difficult to correlate with onset in particular areas in the occipital lobes, and the EEG recordings have not been able to overcome this ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00626.x

    authors: Leal A,Dias A,Vieira JP,Secca M,Jordão C

    更新日期:2006-09-01 00:00:00

  • Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats.

    abstract::We showed that hypoxia is acutely epileptogenic in immature but not in adult rats. In the present study, we evaluated whether hypoxia results in an increase in long-term seizure susceptibility to flurothyl and whether this is associated with impaired performance on behavioral tests. We also determined whether these lo...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1992.tb01746.x

    authors: Jensen FE,Holmes GL,Lombroso CT,Blume HK,Firkusny IR

    更新日期:1992-11-01 00:00:00

  • Toxocara infection and epilepsy in children: a case-control study.

    abstract::A case-control study of 305 children was done to evaluate the relationship between toxocariasis and seizures and risk factors associated with toxocariasis transmission and seizure onset. A significant association existed between seropositivity for anti-Toxocara canis and seizures (p less than 0.05); the correlation wa...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1990.tb05356.x

    authors: Arpino C,Gattinara GC,Piergili D,Curatolo P

    更新日期:1990-01-01 00:00:00

  • Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment.

    abstract::The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1985.tb05656.x

    authors: Löscher W,Siemes H

    更新日期:1985-07-01 00:00:00

  • MEG correlates of epileptic high gamma oscillations in invasive EEG.

    abstract::In patients with pharmacoresistant focal epilepsy,we demonstrate that magnetoencephalography (MEG) detects spike-locked and spike-independent epileptic high gamma oscillations (HGOs) using combined MEG and invasive electroencephalography (iEEG) from subdural macroelectrodes. Six patients, who underwent presurgical wor...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2010.02579.x

    authors: Rampp S,Kaltenhäuser M,Weigel D,Buchfelder M,Ingmar Blümcke I,Dörfler A,Stefan H

    更新日期:2010-08-01 00:00:00