Development of a genomics module within an epilepsy-specific electronic health record: Toward genomic medicine in epilepsy care.

abstract：:We present a review of phenotype-genotype correlation and the genetics of photosensitivity. The photoparoxysmal response in EEG (PPR) is still one of the best paradigms for exogenously triggered brain responses based on a genetic predisposition. The definition of the PPR phenotype requires multiple, precise methodolog...

journal_title：Epilepsia

authors： Stephani U,Tauer U,Koeleman B,Pinto D,Neubauer BA,Lindhout D

更新日期：2004-01-01 00:00:00

abstract：:Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

journal_title：Epilepsia

authors： Cho KH,Cho YJ,Lee BI,Heo K

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：:We examined the seizure records of 13 patients (nine men and four women, ages 27-50 years) with intractable partial epilepsy, maintained with steady anti-epileptic drug dosages. Patients recorded daily seizure frequency on calendars. Periods of outpatient observation ranged from 99 to 1,710 days and the number of obse...

journal_title：Epilepsia

authors： Balish M,Albert PS,Theodore WH

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. METHODS:In acute studies of anticonvulsant efficacy, the AEDs were administered via or...

journal_title：Epilepsia

authors： White HS,Franklin MR,Kupferberg HJ,Schmutz M,Stables JP,Wolf HH

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...

journal_title：Epilepsia

authors： Leonhardt G,de Greiff A,Weber J,Ludwig T,Wiedemayer H,Forsting M,Hufnagel A

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:We studied the effect of vagus nerve stimulation (VNS) on seizure reduction in patients with intractable epilepsy with bilateral independent temporal lobe foci. METHODS:Ten patients who met the criterion of the presence of two distinctive clinical and ictal EEG seizure patterns were identified and followed up ...

journal_title：Epilepsia

authors： Alsaadi TM,Laxer KD,Barbaro NM,Marks WJ Jr,Garcia PA

更新日期：2001-07-01 00:00:00

abstract：:The management of epilepsy is an essential clinical issue in many patients with brain tumors. Tumoral epilepsy is often drug resistant and is associated with poor quality of life. Surgery represents a key therapeutic option in the management of patients with refractory tumoral epilepsy, with high rates of postoperativ...

journal_title：Epilepsia

authors： Rheims S,Ducray F,Ryvlin P

更新日期：2013-12-01 00:00:00

abstract：:Fluoxetine was evaluated for anticonvulsant effects in a rat model of focally evoked complex partial seizures (CPS) secondarily generalized. Fluoxetine was administered intraperitoneally (i.p.) 1 h before seizures were induced by focal intracerebral application of the GABAA receptor antagonist, bicuculline methiodide ...

journal_title：Epilepsia

authors： Prendiville S,Gale K

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To clarify the electroclinical manifestation of epileptic seizures and the evolution of epilepsy in patients with peroxisomal diseases. METHODS:Retrospective review of the medical records and EEGs of 14 patients with peroxisomal diseases: seven with Zellweger syndrome (ZS), two with neonatal adrenoleukodystrop...

journal_title：Epilepsia

authors： Takahashi Y,Suzuki Y,Kumazaki K,Tanabe Y,Akaboshi S,Miura K,Shimozawa N,Kondo N,Nishiguchi T,Terada K,Orii T

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...

journal_title：Epilepsia

authors： Kim HD,Clancy RR

更新日期：1997-11-01 00:00:00

abstract：:Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, a...

journal_title：Epilepsia

authors： Tomson T,Svanborg E,Wedlund JE

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:Febrile seizures (FS) are the most common type of convulsive events in children. FS are suggested to result from a combination of genetic and environmental factors. However, the pathophysiologic mechanisms underlying FS remain unclear. Using an animal model of experimental FS, it was demonstrated that hyperther...

journal_title：Epilepsia

authors： Schuchmann S,Hauck S,Henning S,Grüters-Kieslich A,Vanhatalo S,Schmitz D,Kaila K

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. METHODS:We studied pre- and postoperative neuropsychological test res...

journal_title：Epilepsia

authors： Szabó CA,Wyllie E,Stanford LD,Geckler C,Kotagal P,Comair YG,Thornton AE

更新日期：1998-08-01 00:00:00

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To evaluate the demographic impact of epilepsy a rural area of Africa. METHODS:A cohort study was conducted between 1991 and 2001 in the Mbam Valley (Cameroon) on two groups of subjects (one of persons with epilepsy, and the other of control individuals matched for sex, age, and village of residence). At the e...

journal_title：Epilepsia

authors： Kamgno J,Pion SD,Boussinesq M

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To analyze the relationship between ictal electroencephalography (EEG) and ictal single-photon emission computed tomography (SPECT) and to evaluate the diagnostic usefulness of ictal SPECT as an independent presurgical evaluation technique. METHODS:Sixty-eight patients with temporal lobe epilepsy who underwent...

journal_title：Epilepsia

authors： Lee SK,Lee SH,Kim SK,Lee DS,Kim H

更新日期：2000-08-01 00:00:00

abstract：:Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...

journal_title：Epilepsia

authors： Stefan H,Schäfer H,Kuhnen C,Schneider S

更新日期：1988-09-01 00:00:00

abstract：PURPOSE:Herein we used electrophysiologic approaches in hippocampal area CA1 to estimate how morphine treatment alters the pentylenetetrazol (PTZ) effects. METHODS:Hippocampal slices taken from either control animals or animals made dependent via chronic morphine administration were examined. Changes in the population...

journal_title：Epilepsia

authors： Jafarzadeh Z,Fathollahi Y,Semnanian S,Omrani A,Salmanzadeh F,Salmani ME

更新日期：2009-04-01 00:00:00

abstract：:Spontaneously epileptic rats (SER) are a double mutant (zi/zi, tm/tm) spontaneously exhibiting both tonic and absence-like seizures. We examined the long-term effects of continual intake of phenobarbital (PB) on SER as a method of assessing long-term evaluation of antiepileptic drugs (AEDs). Food pellets containing 0....

journal_title：Epilepsia

authors： Serikawa T,Kogishi K,Yamada J,Ohno Y,Ujihara H,Fujita Y,Sasa M,Takaori S

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation ...

journal_title：Epilepsia

authors： Szaflarski JP,Hughes C,Szaflarski M,Ficker DM,Cahill WT,Li M,Privitera MD

更新日期：2003-02-01 00:00:00

abstract：:Tiagabine (TGB) is a recently approved antiepileptic drug (AED) that inhibits y-aminobutyric acid (GABA) reuptake into neurons and glia, a mechanism of action that is specific and unique among the AEDs. TGB is potent and has linear and predictable pharmacokinetics. It has no clinically relevant effects on hepatic meta...

journal_title：Epilepsia

authors： Schachter SC

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To describe the behavioral and EEG topographic correlates of absences with 3-Hz generalized spike-waves and partitioned impairment of consciousness. METHODS:Two adult women had so-called "phantom" absences, characterized by brief and mild impairments of consciousness that were previously inconspicuous to both ...

journal_title：Epilepsia

authors： Vuilleumier P,Assal F,Blanke O,Jallon P

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...

journal_title：Epilepsia

authors： Oishi M,Otsubo H,Kameyama S,Morota N,Masuda H,Kitayama M,Tanaka R

更新日期：2002-11-01 00:00:00

abstract：:Seizures cannot be medically controlled in approximately 40% of people with epilepsy. Although we are beginning to understand how to better treat certain seizure types, we still do not know the regulatory events that determine antiepileptic drug resistance. Proposed pathoetiologic mechanisms include altered expression...

journal_title：Epilepsia

authors： Kobow K,El-Osta A,Blümcke I

更新日期：2013-05-01 00:00:00

abstract：:The anticonvulsant effect of the dihydropyridine calcium channel blocker, nimodipine (NMD) was evaluated against electroshock-induced seizures in mice. At 1 h postdosing, NMD elicited a dose-dependent reduction in the occurrence of tonic hindlimb extension (THE) after maximal electroshock (MES). The calculated ED50 fo...

journal_title：Epilepsia

authors： Sills GJ,Carswell A,Brodie MJ

更新日期：1994-03-01 00:00:00

abstract：:Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug. We report a case of refractory convulsive status epilepticus (CSE) that was successfully controlled with lacosamide. The 38-year-old male patient was admitted for a series of complex partial seizures with secondary generalization leading to refractory C...

journal_title：Epilepsia

authors： Tilz C,Resch R,Hofer T,Eggers C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Mycoplasma pneumoniae, a common respiratory pathogen, has been implicated as an etiology of encephalitis, but there are few reports about it and postencephalitic epilepsy. This study aimed to investigate clinical factors, electroencephalography, and neuroradiologic features of M. pneumoniae-related encephalitis...

journal_title：Epilepsia

authors： Lin JJ,Hsia SH,Wu CT,Wang HS,Lin KL

更新日期：2011-11-01 00:00:00